Gene News and Research

Latest Gene News and Research

Rare disease day focuses on new approach to finding treatment

2,200 babies will be born in the UK on 29th February, of which 30 will die of a rare disease before they are five years old.

29 Feb 2016

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels

A 59-year-old heart patient with dangerously high levels of cholesterol that could not be adequately reduced by statin drugs now has near-normal cholesterol levels, thanks to a new class of drugs that grew out of work done by UT Southwestern Medical Center researchers.

27 Feb 2016

Discovery could lead to better therapies for people with obsessive compulsive disorder

Research led by investigators in veterinary and human medicine has identified genetic pathways that exacerbate severity of canine compulsive disorder in Doberman pinschers, a discovery that could lead to better therapies for obsessive compulsive disorder in people.

27 Feb 2016

Mice with lymphatic defects develop obesity late in life

Lymphatic vessels play multifaceted roles in the body, including the absorption of dietary lipid in the intestines as well as the movement of immune cells throughout the body. Previous work by Guillermo Oliver and colleagues showed that mice with lymphatic defects due to loss of one copy of the Prox1 gene developed obesity late in life.

27 Feb 2016

Researchers develop effective technique for studying high-arched palate using mouse model

Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.

27 Feb 2016

New drug shows promise against Huntington's disease

A drug that would be the first to target the cause of Huntington's disease (HD) is effective and safe when tested in mice and monkeys, according to data released today that will be presented at the American Academy of Neurology's 68th Annual Meeting in Vancouver, Canada, April 15 to 21, 2016.

27 Feb 2016

Matched ChIP-validated Antibodies & Primer Sets

Chromatrap announces that its high quality ChIP-validated antibodies can now be supplied with optimised matching primer sets.

From Chromatrap® - Porvair Sciences Ltd 26 Feb 2016

Lilly announces CHMP positive opinion for ixekizumab for treatment of adults with plaque psoriasis

Eli Lilly and Company announced today that the European Medicines Agency's Committee for Medicinal Products for Human Use has issued a positive opinion for ixekizumab for the treatment of moderate-to-severe plaque psoriasis in adults in the European Union who are candidates for systemic therapy.

26 Feb 2016

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

Genome sequencing shows association between STIs and Trachoma

For the first time, genome sequencing has been carried out on Chlamydia trachomatis (C. trachomatis), a bacteria responsible for the disease Trachoma - the world's leading infectious cause of blindness, according to a study in Nature Communications.

26 Feb 2016

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

An international research team has identified four likely new subtypes of a rare brain tumor using molecular techniques that lay the foundation for more accurate diagnosis and tailored therapies for the hard-to-treat cancer. Scientists at St. Jude Children's Research Hospital and the German Cancer Research Center led the study, results of which appear today in the scientific journal Cell.

26 Feb 2016

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Baxalta Incorporated, a global biopharmaceutical leader dedicated to delivering transformative therapies to patients with orphan diseases and underserved conditions, announced today that it has submitted supplemental Biologics License Applications (sBLAs) to the U.S. Food and Drug Administration seeking approval for the use of ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] to treat children under the age of 12 with hemophilia A and for use in surgical settings.

26 Feb 2016

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

An international team led by Australian researchers has studied the genetics of pancreatic cancer, revealing it is actually four separate diseases, each with different genetic triggers and survival rates, paving the way for more accurate diagnoses and treatments.

25 Feb 2016

New anti-ageing therapy may be effective against aplastic anaemia

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an important link with the ageing process: the shortening of telomeres, structures that protect the ends of chromosomes.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Ground-breaking discovery could lead to new treatments for diabetes

Why would a bacteria-killing protein be present in an area of the body that is not normally exposed to bacteria, like the pancreas? Researchers at The Ottawa Hospital and the University of Ottawa puzzled over this question for some time, until they eventually discovered that the protein in question was doing something entirely unexpected - it was actually helping the pancreas regenerate and produce insulin.

25 Feb 2016

Okayama University e-Bulletin highlights role of designer DNA-binding proteins to fight viral infections in agriculture, medicine

This issue includes a feature on designer DNA-binding proteins to combat viral infections in agriculture and medicine; news items include updates of official opening of the Okayama University Silicon Valley Office at Fremont (CA), and international collaboration work with Xiamen University; research highlights on immunizing plants; identification of gene Vrn-D4 for enabling wheat to adapt to areas with warm winters; importance of introgression on intra-specific genetic differentiation and adaptive divergence; an interesting twist on supercooled liquid water; and manufacturing denim in Okayama.

25 Feb 2016

Active mind may delay symptoms of Alzheimer's disease, but not underlying brain changes

Keeping the mind active may delay symptoms of Alzheimer's disease; however, the activity does not change the underlying disease in the brain for most people, according to a study published today in the online edition of Neurology, the medical journal of the American Academy of Neurology.

25 Feb 2016

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced the presentation of immunological data from the Company's clinical trials of SB-728-T, a ZFP Therapeutic designed to provide functional control of HIV.

25 Feb 2016

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

A patient with recurrent metastatic colorectal cancer has been successfully treated with the angiotensin receptor blocker irbesartan, researchers report.

24 Feb 2016

Gene News and Research

Latest Gene News and Research

Rare disease day focuses on new approach to finding treatment

PCSK9-inhibitor drugs: A game-changer for individuals with extremely high cholesterol levels

Discovery could lead to better therapies for people with obsessive compulsive disorder

Mice with lymphatic defects develop obesity late in life

Researchers develop effective technique for studying high-arched palate using mouse model

New drug shows promise against Huntington's disease

Matched ChIP-validated Antibodies & Primer Sets

Lilly announces CHMP positive opinion for ixekizumab for treatment of adults with plaque psoriasis

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Genome sequencing shows association between STIs and Trachoma

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

Baxalta seeks FDA approval for ADYNOVATE to treat children with hemophilia A and for use in surgical settings

Pancreatic cancer identified as four separate diseases with different genetic triggers, survival rates

New anti-ageing therapy may be effective against aplastic anaemia

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Ground-breaking discovery could lead to new treatments for diabetes

Okayama University e-Bulletin highlights role of designer DNA-binding proteins to fight viral infections in agriculture, medicine

Active mind may delay symptoms of Alzheimer's disease, but not underlying brain changes

Sangamo presents immunological data from SB-728-T HIV clinical study at CROI 2016

Gene expression analysis points metastatic CRC patient to successful irbesartan therapy

eBook: Using iPSCs models for human disease research and drug discovery eBook

How the Vutara VXL simplifies single-molecule imaging

How cohesin mechanics and nanotracker tech are redefining DNA research

Todd Bauman and Chris Povich