Immunotherapy News and Research

Latest Immunotherapy News and Research

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a promising new strategy in the fight against cancer.

11 Jan 2022

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Researchers screened BNT162b2 COVID-19 vaccine recipients and cloned broadly neutralizing antibodies from an elite vaccinee.

10 Jan 2022

Researchers illuminate the molecular landscape and clinical features of rare kidney cancer

Translocation renal cell carcinoma (tRCC) is a rare and aggressive form of kidney cancer. It accounts for about 5 percent of all renal cell carcinomas in adults and about 50 percent in children.

10 Jan 2022

New grant program launches to advance therapeutic discovery for follicular lymphoma

Today saw the launch of a dedicated grant program aimed at advancing therapeutic discovery for follicular lymphoma (FL), The Follicular Lymphoma Foundation (FLF) CURE FL Awards - Curative Research to Eliminate Follicular Lymphoma.

10 Jan 2022

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

7 Jan 2022

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

6 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.

5 Jan 2022

Structural blueprint of nanoparticles developed to target neutrophils responsible for acute lung inflammation

The COVID-19 pandemic highlighted the devastating impact of acute lung inflammation (ALI), which is part of the acute respiratory distress syndrome (ARDS) that is the dominant cause of death in COVID-19.

28 Dec 2021

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

Scientists at the La Jolla Institute for Immunology have uncovered how loss of TET enzymes can lead to B cell lymphoma. Their research, published in Nature Immunology, could potentially open opportunities for designing drug treatment strategies to target malignant cells in many cancers.

24 Dec 2021

High-fiber diet helps melanoma patients to respond better to immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration that includes the Oregon State University College of Pharmacy.

24 Dec 2021

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Dietary fiber and probiotics impact gut bacteria and immunotherapy responses in melanoma patients, a new study in patients shows.

24 Dec 2021

Peto's paradox offers new insights into cancer risk across mammals

The cells in the body can be thought of as tiny archery targets, each vulnerable to the deadly arrow of cancer.

23 Dec 2021

Fiber-rich diet may help some melanoma patients to respond to immunotherapy

A diet rich in fiber may help some people being treated for melanoma respond to immunotherapy treatment by influencing the gut microbiome, according to a new study led by researchers at the Center for Cancer Research at the National Cancer Institute, part of the National Institutes of Health, and the University of Texas MD Anderson Cancer Center.

23 Dec 2021

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

In cancer, a major obstacle to anti-tumor immunity and immunotherapy treatment is the infiltration of regulatory T cells, or T-reg cells, into a tumor. These immune cells generally turn down the immune response, and they can prevent the immune system from destroying cancer cells.

22 Dec 2021

Scientists develop new immunotherapy for cancer based on transplant rejection mechanism

A team of scientists at the University of Oslo, Oslo University Hospital Radiumhospitalet and Karolinska Institutet, led by Professor Johanna Olweus, has developed a new type of immunotherapy for cancer.

18 Dec 2021

Study may lead to a paradigm shift in the care for adults who relapse from large B-cell lymphoma

A study published this month in the New England Journal of Medicine (NEJM) may change the standard of care for adults who relapse from large B-cell lymphoma.

17 Dec 2021

University of Birmingham launches 5 new major studies focused on management of type 1 diabetes

The University of Birmingham today announces the launch of five new major studies aimed at improving the prevention, treatment and management of type 1 diabetes – with a particular focus on children and young adults.

17 Dec 2021

Study provides a more effective treatment approach to preventing graft-versus-host-disease

A new study led by UC Davis Health researchers showed that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease (GVHD), an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation (allo-HSCT).

16 Dec 2021

Nanoparticle therapeutic can be a potential new approach for treating malignant pleural effusion

Researchers at Wake Forest School of Medicine have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE).

16 Dec 2021

Immunotherapy News and Research

Latest Immunotherapy News and Research

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Researchers illuminate the molecular landscape and clinical features of rare kidney cancer

New grant program launches to advance therapeutic discovery for follicular lymphoma

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

In vivo generation of engineered CAR T cells can reduce fibrosis and restore cardiac function after heart injury

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

Structural blueprint of nanoparticles developed to target neutrophils responsible for acute lung inflammation

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

High-fiber diet helps melanoma patients to respond better to immunotherapy

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Peto's paradox offers new insights into cancer risk across mammals

Fiber-rich diet may help some melanoma patients to respond to immunotherapy

Transcription factor Blimp1 identified as potential target for modulating T-reg activity to treat cancer

Scientists develop new immunotherapy for cancer based on transplant rejection mechanism

Study may lead to a paradigm shift in the care for adults who relapse from large B-cell lymphoma

University of Birmingham launches 5 new major studies focused on management of type 1 diabetes

Study provides a more effective treatment approach to preventing graft-versus-host-disease

Nanoparticle therapeutic can be a potential new approach for treating malignant pleural effusion

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Immunotherapy News and Research

Latest Immunotherapy News and Research

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

How can super-resolution technology help study neurotransmission?

The Proteoform Puzzle: Unlocking the Next Frontier

Synthetic Biology and the Pursuit of Living Diagnostics

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