Male Infertility

Male infertility is on the rise in society. Approximately 15% of married couples have trouble conceiving despite having regular unprotected sex for more than a year. Out of the couples who are in their thirties, only 30% are able to conceive within the first three months; the rest have trouble due to male infertility issues.

How is Male Infertility Diagnosed?

Should a couple have trouble conceiving, despite trying for more than a year, both partners may be checked for issues leading to infertility. Evaluating infertility is different for men and women. The health care provider will start by asking the couple specific questions about their medical history in order to isolate the possible causes of infertility.

Male Infertility Research

Obesity and Sexual Health

Penile Birth Defects

Infections with Genital Mycoplasmas in Men

Sperm Production Problems

Fertility and Age

Intracytoplasmic Sperm Injection (ICSI)

Symptoms and Causes of Undescended Testicles

Testing for a Low Sperm Count

Causes of Male Infertility

Preventing Male Infertility

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Men's Health in the Workplace

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Artificial Insemination

Infertility Psychological Effects

Male Infertility Epidemiology

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IVF: Chances of Success

Testing for a Low Sperm Count

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Does Smoking Marijuana Affect Sperm?

Misconceptions about Infertility and IVF

Intracytoplasmic Sperm Injection (ICSI)

Blockage of Sperm Transport

The 'Omics in Male Fertility Diagnostics

Erection and Ejaculation Problems

The Effects of Neanderthal DNA on Modern Human Health

How Can Sleep Affect Men's Health?

Low Sperm Count

Latest Male Infertility News and Research

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

Study uncovers key protein complex controlling sperm motility and male fertility

Infertility affects about one in six couples, and male factors account for roughly half of all cases-often because sperm don't swim well.

13 Oct 2025

New insights into sperm metabolism could transform infertility treatments

Michigan State University scientists have pinpointed the molecular "switch" that supercharges sperm for their final sprint to an egg - a breakthrough that could reshape infertility treatments and pave the way for safe, nonhormonal male contraceptives.

10 Oct 2025

Lifestyle choices and hormonal imbalances can impact men's reproductive health

A new research paper was published in Volume 12 of Oncoscience on September 30, 2025, titled "Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study."

10 Oct 2025

Organophosphate pesticide exposure linked to reduced sperm quality in healthy men

This pilot study found that urinary metabolites of organophosphate pesticides were linked to reduced sperm motility in healthy young men, though results were preliminary. Oxidative stress did not explain the association, suggesting other biological pathways may be involved.

25 Sep 2025

Loss of key Y chromosome gene causes infertility in male mice

In a new study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have shown that the loss of a key male fertility gene leads to infertility and changes expression of hundreds of other important genes.

17 Sep 2025

Key proteins found to shape sperm function and male fertility

There are many potential causes of infertility, and it can be challenging to pin down just what the problem is when a couple is having trouble getting pregnant.

10 Sep 2025

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.

12 Jul 2025

Mediterranean diet boosts sperm health while ultra-processed foods lower fertility, study finds

Adherence to the Mediterranean diet is linked to improved sperm parameters in men, while high intake of ultra-processed foods is associated with poorer semen quality. These associations are strongest in men with normal FSH levels, suggesting dietary patterns may influence male fertility.

23 Jun 2025

Scientists find hundreds of genes that behave like light switches

Gene expression, where cells use the genetic information encoded in DNA to produce proteins, has been thought of as a dimmer light.

19 Jun 2025

Sucralose disrupts male fertility by damaging sperm and altering hormones in animal study

Researchers found that chronic sucralose exposure in male rats disrupted reproductive hormones, damaged sperm, and impaired testicular function through oxidative stress and autophagy dysregulation. These findings raise concerns about the reproductive risks of high sucralose intake and its persistent presence in the environment.

19 May 2025

Low phosphate levels may help explain male infertility, study finds

Men with fertility problems were significantly more likely to have low blood phosphate levels, a mineral essential for energy and reproductive function. Researchers found lower phosphate was linked to poorer sperm motility, suggesting a possible pathway for new fertility treatments.

10 May 2025