Male Infertility

Male infertility is on the rise in society. Approximately 15% of married couples have trouble conceiving despite having regular unprotected sex for more than a year. Out of the couples who are in their thirties, only 30% are able to conceive within the first three months; the rest have trouble due to male infertility issues.

How is Male Infertility Diagnosed?

Should a couple have trouble conceiving, despite trying for more than a year, both partners may be checked for issues leading to infertility. Evaluating infertility is different for men and women. The health care provider will start by asking the couple specific questions about their medical history in order to isolate the possible causes of infertility.

Semen Physiology

IVF: Chances of Success

Blockage of Sperm Transport

Infertility Psychological Effects

Erection and Ejaculation Problems

Infections with Genital Mycoplasmas in Men

How Can Sleep Affect Men's Health?

Causes of a Low Sperm Count

Testing for a Low Sperm Count

Intracytoplasmic Sperm Injection (ICSI)

Artificial Insemination

See more featured articles »

Causes of Male Infertility

Low Sperm Count

Can Men Improve the Chances of a Successful Pregnancy?

Symptoms and Causes of Undescended Testicles

Obesity and Sexual Health

Male Infertility Research

The 'Omics in Male Fertility Diagnostics

The Effects of Neanderthal DNA on Modern Human Health

Fertility and Age

Do Stress and Anxiety Affect Sperm Quality?

Men's Health in the Workplace

Misconceptions about Infertility and IVF

Preventing Male Infertility

Intracytoplasmic Sperm Injection (ICSI)

Testing for a Low Sperm Count

Penile Birth Defects

Male Infertility Epidemiology

Does Smoking Marijuana Affect Sperm?

Men's Health: An Overview

Sperm Production Problems

Male Age and Fertility

Latest Male Infertility News and Research

Melatonin receptor signaling counters sleep fragmentation-mediated infertility in T2DM

This new article publication from Acta Pharmaceutica Sinica B, discusses how melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.

12 Jul 2025

Mediterranean diet boosts sperm health while ultra-processed foods lower fertility, study finds

Adherence to the Mediterranean diet is linked to improved sperm parameters in men, while high intake of ultra-processed foods is associated with poorer semen quality. These associations are strongest in men with normal FSH levels, suggesting dietary patterns may influence male fertility.

23 Jun 2025

Scientists find hundreds of genes that behave like light switches

Gene expression, where cells use the genetic information encoded in DNA to produce proteins, has been thought of as a dimmer light.

19 Jun 2025

Sucralose disrupts male fertility by damaging sperm and altering hormones in animal study

Researchers found that chronic sucralose exposure in male rats disrupted reproductive hormones, damaged sperm, and impaired testicular function through oxidative stress and autophagy dysregulation. These findings raise concerns about the reproductive risks of high sucralose intake and its persistent presence in the environment.

19 May 2025

Low phosphate levels may help explain male infertility, study finds

Men with fertility problems were significantly more likely to have low blood phosphate levels, a mineral essential for energy and reproductive function. Researchers found lower phosphate was linked to poorer sperm motility, suggesting a possible pathway for new fertility treatments.

10 May 2025

Heat triggers sperm activation for fertilization in mammals

In mammals - including us humans - sperm are surprisingly picky about temperature, thriving best in conditions a few degrees cooler than normal body temperature.

2 May 2025

COVID-19 lowers sperm count and motility, new study confirms

SARS-CoV-2 infection is linked to significant declines in sperm quality, including reduced sperm count, motility, and increased DNA fragmentation, as shown in both cross-sectional and longitudinal observations.

24 Apr 2025

New discovery shows piRNA's adaptive role in silencing jumping genes

Adverse genetic mutations can cause harm and are due to various circumstances. "Jumping genes" are one cause of mutations, but cells try and combat them with a specialized RNA called piRNA.

20 Mar 2025

Low semen quality linked to shorter lifespan

Researchers determine how low semen quality may impact mortality risk.

10 Mar 2025

Semen quality linked to longevity in men

Men's semen quality is associated with how long they live according to a study of nearly 80,000 men, which is published today (Wednesday) in Human Reproduction, one of the world's leading reproductive medicine journals.

4 Mar 2025

Study unveils protein complex critical for sperm morphology

The human body is full of checks and balances that ensure correct growth, development, and function of all our different systems. Now, researchers from Japan have reported a newly discovered protein interaction that regulates sperm development.

3 Mar 2025

Can red ginseng prevent diabetes? New research uncovers its potential

Red ginseng extract powder significantly improved glycemic control in prediabetic Korean adults over 12 weeks without adverse effects. The findings suggest its potential role in diabetes prevention, though larger studies are needed.

23 Feb 2025

Crick researchers identify key Y chromosome genes influencing sperm development

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

23 Jan 2025

Study unveils role of TLE6 in male sperm development

Infertility is a major global challenge associated with physiological and psychological impact. Genetic mutations that affect early embryonic development, oocyte (egg cell) maturation, and fertilization have recently been studied as causes of infertility.

16 Jan 2025

Could mulberry extract be the key to fighting obesity-induced reproductive dysfunction?

Research indicates mulberry extract's efficacy in addressing obesity-related male infertility, enhancing reproductive outcomes through bioactive compounds.

16 Jan 2025

Genetic insights into reproductive health and longevity

Led by researchers from the University of Oxford's Leverhulme Centre for Demographic Science and the University of Iceland, the review explores how genetic variations can explain differences in reproductive health and longevity.

14 Dec 2024

How alcohol impacts male health

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, emphasizing the complex mechanisms and public health implications.

18 Nov 2024

How carnitine transporters boost reproductive health

Research uncovers the critical role of carnitine transporters in maintaining fertility by regulating energy metabolism and protecting reproductive cells from oxidative stress. It suggests new pathways for treating infertility through carnitine supplementation and targeted therapies.

6 Oct 2024

Vitamin B12 boosts testosterone levels in men with infertility

Research finds that higher serum vitamin B12 levels are associated with improved testosterone concentrations in men with infertility, but no impact on other reproductive hormones.

30 Sep 2024

NIH funds study on environmental impact on male fertility

A grant from the National Institutes of Health will support ongoing research at Wayne State University investigating the consequences environmental factors may have on fertility in males.

18 Sep 2024