Melanoma News and Research

Latest Melanoma News and Research

Combination therapy produces clinical benefit for early stage non-small cell lung cancer

The first randomized Phase II clinical trial to report on single and combined neoadjuvant immune checkpoint inhibitor therapy in stage I-III non-small cell lung cancer (NSCLC) found combination therapy produced a significant clinical benefit, as assessed by major pathologic response (MPR) rate, as well as enhanced tumor immune cell infiltration and immunological memory.

18 Feb 2021

Novel hydrogel slowly releases RNA nanovaccines to shrink tumors

Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer.

17 Feb 2021

Mathematical model reveals how cell turnover determines the success of adaptive therapy

One of the most challenging issues in cancer therapy is the development of drug resistance and subsequent disease progression.

17 Feb 2021

New system distinguishes suspicious pigmented lesions from non-suspicious ones

Melanoma is by far the deadliest form of skin cancer, killing more than 7,000 people in the United States in 2019 alone.

17 Feb 2021

Changes to gut microbiome help melanoma patients respond to immunotherapy

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit.

16 Feb 2021

Research shows how chemicals in the tumor microenvironment enable cancer to evade attack

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

15 Feb 2021

Scientists discover new immunotherapy target for malignant brain tumors

Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

Algorithm for skin cancer diagnosis performs on par with dermatologists

A study has now been presented that boosts the evidence for using AI solutions in skin cancer diagnostics.

13 Feb 2021

Scientists avert drug resistance in subtype of brain tumors

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice.

11 Feb 2021

Modified CRISPR/Cas9 complex targets specific histones

Finding a needle in a haystack is hard enough. But try finding a specific molecule on the needle.

9 Feb 2021

Fecal transplant overcomes resistance to immunotherapy in melanoma patients

Researchers at UPMC Hillman Cancer Center and the National Cancer Institute demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy - which has a failure rate of 40% for this type of cancer - into patients who do.

5 Feb 2021

Biomarkers could help discriminate cancer therapy-associated kidney injury from other causes

A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

3 Feb 2021

Tiny molecular motions are of key significance in modern anti-cancer drugs

Modern immunotherapeutic anti-cancer drugs support a natural mechanism of the immune system to inhibit the growth of cancer cells.

3 Feb 2021

Breast cancer‐on‐a‐chip to test the effectiveness of checkpoint inhibitor drugs

There are many mechanisms by which the body responds to foreign invaders. One of these involves the T-cells of the immune system, which have a number of different proteins on their surface called "checkpoint proteins."

2 Feb 2021

Study discovers promising therapeutic agent to inhibit melanoma progression

There have been great advances in treating melanoma over the past five years, however, even with these treatments many patients quickly develop drug resistance and die from their disease.

1 Feb 2021

Study: Targeting glycoprotein could improve response to cancer immunotherapy

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.

28 Jan 2021

Genetic changes in tumors can help predict the efficacy of immunotherapy drugs

Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumors which could be used to predict if immunotherapy drugs would be effective in individual patients.

28 Jan 2021

Insight into cancer cells' own first aid could provide the basis for new immunotherapy

Insight into cancer cells' own first aid could help the development of a new type of treatment. Johanna Olweus and her team at the UiO (University of Oslo) and the OUS (Oslo University Hospital) are important contributors to this study, which has been published in Nature.

27 Jan 2021