Metabolism News and Research

Latest Metabolism News and Research

GnRH infusion recommended for adolescent hypogonadotropic hypogonadodism

Pulsatile gonadotropin-releasing hormone may be more effective than human chorionic gonadotropin for the treatment of peripubescent boys with hypogonadotropic hypogonadodism, say Chinese researchers.

27 May 2015

AbbVie announces new results from Phase 3 GIFT-I study in GT1b HCV infected Japanese patients

AbbVie presented new results from the Phase 3 GIFT-I study of its investigational, all-oral, interferon (IFN)- and ribavirin (RBV)-free, two direct-acting antiviral treatment with ombitasvir/paritaprevir/ritonavir at the Annual Meeting of the Japan Society of Hepatology in Kumamoto, Japan.

27 May 2015

Lafora rare disease could be aggravated by oxidative stress

Neurodegenerative Lafora disease usually becomes apparent through seizures during adolescence and puberty and occurs as a consequence of defects in glycogen metabolism and in the cellular mechanisms that are responsible for its disposal. Researchers at the University of Valencia have led a study in which they propose that Lafora rare disease could be aggravated by oxidative stress.

22 May 2015

New study suggests ways to accelerate recovery from dangerous diarrheal disease

A new study delineates a sequential pattern of changes in the intestinal microbial population of patients recovering from cholera in Bangladesh, findings that may point to ways of speeding recovery from the dangerous diarrheal disease.

20 May 2015

Researcher uses short pulsed electric fields to preserve milk

Even though much of the population in developing countries is involved in agriculture, food security is virtually out of reach. Often the only resort is to purchase a cow, buffalo, or sheep, to provide a steady supply of fresh milk, a nutritious staple of a daily diet. But how to preserve it safely? Refrigeration and boiling are costly -- and often impossible due to sporadic electricity.

20 May 2015

Leptin resistance not a possible cause of obesity, scientists find

For years, scientists have pointed to leptin resistance as a possible cause of obesity. Research led by investigators at the University of Cincinnati (UC) Metabolic Diseases Institute, however, found that leptin action isn't the culprit.

19 May 2015

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

Data will be presented at both Digestive Disease Week (DDW) and the American Association of Clinical Endocrinologists (AACE) annual medical meetings.

18 May 2015

New findings could help better understand neurodegenerative diseases

Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB), of the University of Luxembourg, have, under Dr. Manuel Buttini, successfully measured metabolic profiles, or the metabolomes, of different brain regions, and their findings could help better understand neurodegenerative diseases.

18 May 2015

Drug combination lengthens lives of metastatic colorectal cancer patients

A drug developed 50 years ago and abandoned because it was considered to be too toxic has gained a second life in an international clinical trial. Research led by scientists at Dana-Farber Cancer Institute showed the drug and a potentiating agent lengthened the lives of patients with metastatic colorectal cancer, all of whom had exhausted available standard treatments.

15 May 2015

Study evaluates prenatal nutrition and genome-wide DNA patterns in adults exposed to malnutrition

Researchers at Columbia University's Mailman School of Public Health and Leiden University in the Netherlands found that children whose mothers were malnourished at famine levels during the first 10 weeks of pregnancy had changes in DNA methylation known to suppress genes involved in growth, development, and metabolism documented at age 59.

15 May 2015

Combination of contraceptive and cholesterol-lowering drugs kills cancer cells in a new way

The combination of a cholesterol-lowering drug, Bezafibrate, and a contraceptive steroid, Medroxyprogesterone Acetate, could be an effective, non-toxic treatment for a range of cancers, researchers at the University of Birmingham have found.

15 May 2015

Serotonin and TGF-beta pathways link diet to health and ageing

Diet exerts a major impact on health and ageing. The nervous system plays an important role in this process but, thus far, how food signals are interpreted by the nervous system has been a mystery.

14 May 2015

New study discovers master switch that drives heart cell maturation process

A molecular switch that seems to be essential for embryonic heart cells to grow into more mature, adult-like heart cells has been discovered.

13 May 2015

Obese people at greater risk of developing cancer

Cancer is more likely to develop in people who are very overweight (obese), because surplus body fat interferes with various hormone cycles and with glucose and fat metabolism. On the occasion of European Obesity Day this coming Saturday (16 May), metabolic expert Alexandra Kautzky-Willer, Comprehensive Cancer Center at MedUni Vienna and Vienna General Hospital, draws attention to the fact that, even in Austria, more and more people are suffering from obesity.

12 May 2015

Brain protein plays key role in controlling binge drinking

Scientists at The Scripps Research Institute have discovered that a brain protein has a key role in controlling binge drinking in animal models. They found that deleting the gene for this protein in mice ramped up alcohol consumption and prevented the brain from signaling the rewarding properties of alcohol.

12 May 2015

β-amyloid deposition highly variable in synucleinopathy

A meta-analysis suggests large variability in the prevalence of β-amyloid deposition in patients with synucleinopathies.

8 May 2015

Removing bacterial biofilms could help prevent and treat colon cancers, study suggests

A team led by scientists at The Scripps Research Institute and Johns Hopkins University School of Medicine has uncovered a big clue to how bacteria may promote some colon cancers.

8 May 2015

Gene therapy is key to addressing Sanfilippo Syndrome, say Ohio scientists and clinicians

Gene therapy is the delivery of DNA into a patient's cells to replace faulty or missing genes—or adds new genes—in an attempt to cure cancer or make changes so the body is better able to fight off disease. Scientists and clinicians have identified a number of different ways to do this, in an effort to correct malfunctioning or mutated genes. Many gene therapy clinical trials are ongoing to assess the safety and potential benefits in patients with rare diseases.

8 May 2015

Researchers reveal mechanisms involved in development of metabolic complications linked to obesity

Metabolic complications of obesity and overweight, such as type 2 diabetes, are an important challenge to public health. Teams led by Nicolas Venteclef, Inserm Research Fellow (Cordeliers Research Centre, Inserm/Pierre and Marie Curie University Joint Research Unit 1138, Paris, France) and Irina Udalova (Kennedy Institute of Rheumatology, University of Oxford, UK) in collaboration with several teams, have succeeded in elucidating part of the mechanisms involved in the development of these metabolic complications associated with obesity.

8 May 2015

Phosphate Therapeutics reports positive results from PT20 trial in people with hyperphosphataemia

Phosphate Therapeutics Limited, a development-stage specialty pharmaceuticals company, today announces positive results from the PEACH pivotal study of PT20 in subjects with hyperphosphataemia related to dialysis dependent chronic kidney disease (DD-CKD).

7 May 2015

Metabolism News and Research

Latest Metabolism News and Research

GnRH infusion recommended for adolescent hypogonadotropic hypogonadodism

AbbVie announces new results from Phase 3 GIFT-I study in GT1b HCV infected Japanese patients

Lafora rare disease could be aggravated by oxidative stress

New study suggests ways to accelerate recovery from dangerous diarrheal disease

Researcher uses short pulsed electric fields to preserve milk

Leptin resistance not a possible cause of obesity, scientists find

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

New findings could help better understand neurodegenerative diseases

Drug combination lengthens lives of metastatic colorectal cancer patients

Study evaluates prenatal nutrition and genome-wide DNA patterns in adults exposed to malnutrition

Combination of contraceptive and cholesterol-lowering drugs kills cancer cells in a new way

Serotonin and TGF-beta pathways link diet to health and ageing

New study discovers master switch that drives heart cell maturation process

Obese people at greater risk of developing cancer

Brain protein plays key role in controlling binge drinking

β-amyloid deposition highly variable in synucleinopathy

Removing bacterial biofilms could help prevent and treat colon cancers, study suggests

Gene therapy is key to addressing Sanfilippo Syndrome, say Ohio scientists and clinicians

Researchers reveal mechanisms involved in development of metabolic complications linked to obesity

Phosphate Therapeutics reports positive results from PT20 trial in people with hyperphosphataemia

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