Metabolism News and Research

Latest Metabolism News and Research

Berg and University of Miami extend partnership to battle cardiac dysfunction, heart failure

Berg, a Boston-based biopharmaceutical company, and the University of Miami Leonard M. Miller School of Medicine are extending its collaboration to battle cardiac dysfunction and heart failure. According to the American Heart Association, cardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030.

23 Aug 2015

New genome-wide association study sheds light on the underlying biology of polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) has been passed down in many families for generations -- causing reproductive and metabolic health problems for millions of women around the world. Yet, its cause remains unknown despite more than 80 years of research since the disorder was first described in 1935.

20 Aug 2015

Energy-burning 'good' fat helps reduce weight gain, lower blood glucose levels in mice

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose levels in mice.

20 Aug 2015

Researchers uncover genetic circuit involved in obesity

Like many other conditions, obesity is caused by an interplay between genetic and environmental factors. While efforts to combat the obesity epidemic will need to include changes in diet and exercise, insights into the genes involved may also help with prevention and treatment.

20 Aug 2015

Multi-national group of scientists developing new test for Hepatocellular Carcinoma

A group of clinicians and geochemists are working to develop a test for the most common form of primary liver cancer, HCC (Hepatocellular Carcinoma). HCC kills over 600,000 people worldwide every year.

19 Aug 2015

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Despite decades of warnings about smoking, lung cancer is still the second-most common cancer and the leading cause of death from cancer in the U.S. Patients are often diagnosed only when their disease is already at an advanced stage and hard to treat. Researchers at the West Coast Metabolomics Center at UC Davis are trying to change that, by identifying biomarkers that could be the basis of early tests for lung cancer.

19 Aug 2015

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Intarcia Therapeutics, Inc. today announced positive top-line results from its 52-week Phase 3 FREEDOM-2 clinical trial to determine the comparative efficacy of the company's late-stage investigational candidate ITCA 650 to Merck's Januvia in reducing HbA1c in patients with type 2 diabetes following a year of treatment.

18 Aug 2015

Muscle mass appears to ward off bad cardiovascular effects of obesity

Even without losing fat, more muscle appears to go a long way in fighting off the bad cardiovascular effects of obesity. That emerging evidence has scientists looking hard for new targets to uncouple the unhealthy relationship between fat and cardiovascular disease.

18 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

Adolescent and young adult patients with chronic myeloid leukaemia may have an unfavourable outcome on tyrosine kinase inhibitor therapy compared with their older counterparts, suggests a study of Japanese patients.

17 Aug 2015

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

Chiasma, Inc., a U.S. late-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application (NDA) for the marketing and sale of octreotide capsules, an oral drug proposed for the maintenance therapy of adult patients with acromegaly.

17 Aug 2015

TKI outcomes ‘unfavourable’ in young CML patients

14 Aug 2015

‘Medical foods’ for patients with rare IEMs may cause harm when not carefully managed

Many "medical foods" are designed to help manage patients with rare inborn errors of metabolism (IEMs), and can help prevent serious and life-threatening complications. However, such special foods may cause harm in some patients when their use is not carefully monitored and managed, according to a research team led by scientists at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.

14 Aug 2015

Low-fat diets better than low-carb diets for weight loss, NIH study finds

In a recent study, restricting dietary fat led to body fat loss at a rate 68 percent higher than cutting the same number of carbohydrate calories when adults with obesity ate strictly controlled diets. Carb restriction lowered production of the fat-regulating hormone insulin and increased fat burning as expected, whereas fat restriction had no observed changes in insulin production or fat burning.

14 Aug 2015

Food ingredient formulators use different ways to enhance absorption, bioavailability of curcumin, turmeric

Few natural products have demonstrated the range of protective and therapeutic promise as have turmeric and its principal bioactive components, the curcuminoids.

13 Aug 2015

Gastric bypass surgery enhances energy expenditure

Gastric bypass surgery often leads to a sustained weight loss. Researchers at Sahlgrenska Academy have found part of the explanation: the operation enhances energy expenditure such that eating actually helps the person lose weight.

12 Aug 2015

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Testosterone sales have grown rapidly over the last decade, but few studies have examined the long-term effects of taking testosterone on cardiovascular health and other important outcomes. This week, investigators from Brigham and Women's Hospital report the results of the Testosterone's Effects on Atherosclerosis Progression in Aging Men (TEAAM) trial in the Journal of the American Medical Association.

12 Aug 2015

Gastric bypass surgery enhances energy expenditure, leads to sustained weight loss

11 Aug 2015

Sigma 1 receptor appears to play vital role in supporting the retina

A receptor that is already a target for treating neurodegenerative disease also appears to play a key role in supporting the retina, scientists report.

11 Aug 2015

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Turing Pharmaceuticals AG today announced that it has acquired the exclusive rights to market Daraprim (pyrimethamine) in the U.S. from Impax Laboratories, Inc. The acquisition by Turing is part of a strategic effort focused on treatments for toxoplasmosis and other serious infectious diseases. The company also announced plans to invest in the development of new drug candidates for toxoplasmosis.

10 Aug 2015

Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Lexicon Pharmaceuticals, Inc., today reported financial results for the second quarter ended June 30, 2015 and provided an overview of key milestones for the company's lead drug candidates.

7 Aug 2015

Metabolism News and Research

Latest Metabolism News and Research

Berg and University of Miami extend partnership to battle cardiac dysfunction, heart failure

New genome-wide association study sheds light on the underlying biology of polycystic ovary syndrome

Energy-burning 'good' fat helps reduce weight gain, lower blood glucose levels in mice

Researchers uncover genetic circuit involved in obesity

Multi-national group of scientists developing new test for Hepatocellular Carcinoma

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Intarcia Therapeutics announces positive top-line results from ITCA 650 Phase 3 FREEDOM-2 clinical trial

Muscle mass appears to ward off bad cardiovascular effects of obesity

TKI outcomes ‘unfavourable’ in young CML patients

FDA accepts Chiasma's NDA filing for octreotide capsules for treatment of adult patients with acromegaly

TKI outcomes ‘unfavourable’ in young CML patients

‘Medical foods’ for patients with rare IEMs may cause harm when not carefully managed

Low-fat diets better than low-carb diets for weight loss, NIH study finds

Food ingredient formulators use different ways to enhance absorption, bioavailability of curcumin, turmeric

Gastric bypass surgery enhances energy expenditure

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Gastric bypass surgery enhances energy expenditure, leads to sustained weight loss

Sigma 1 receptor appears to play vital role in supporting the retina

Turing Pharmaceuticals acquires rights to market Daraprim (pyrimethamine) in the U.S.

Lexicon Pharmaceuticals' revenues decrease to $0.4 million in second quarter 2015

Innovation in neuroscience drug discovery - eBook eBook

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation