Metabolism News and Research

Latest Metabolism News and Research

Understanding how individuals respond to aspirin

Researchers have learned new information about how different people respond to aspirin, a globally prescribed drug in cardioprotection. The research team, led by scientists at Cardiff University in the United Kingdom and including representatives from the University of Alabama at Birmingham and the University of Colorado, identified more than 5,600 lipids — or fats — in blood platelets and gained new insights into how these cells respond to aspirin.

29 Apr 2016

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

For smokers who are addicted to alcohol, chronic alcohol abuse may increase the rate of nicotine metabolism and contribute to poor smoking cessation rates. When smokers stop drinking the nicotine metabolism rates decline significantly, according to a study conducted by an international research team led by Roswell Park Cancer Institute. The research was a collaboration of scientists from Roswell Park, the University of California, San Francisco, and the Medical University of Silesia and Center of Addiction Treatment in Poland.

29 Apr 2016

Study links age-related changes in human pancreas to diabetes development

A Stanford-led national collaboration to procure and analyze human pancreatic tissue from deceased donors illustrates how the organ's function changes as we age, and could point the way toward new diabetes treatments.

29 Apr 2016

Researchers report tumors can continue to grow even without supply of new blood vessels

When medication is used to shut off the oxygen supply to tumor cells, the cells adapt their metabolism in the medium term -- by switching over to producing energy without oxygen. This observation by biomedical scientists at the University of Basel and University Hospital Basel could be used for treatments that can inhibit tumor growth in the long term, as the researchers report in the latest issue of the journal Cell Reports.

29 Apr 2016

Probiotic supplements may help treat post-menopausal osteoporosis

Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown.

28 Apr 2016

$Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing$

Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing

In people with osteoporosis, one fracture often leads to more fractures, and potentially a future of pain, disability, and poor quality of life. While studies have shown that such high-risk patients benefit from appropriate medication to reduce future fracture risk, more research is needed on the effect of osteoporosis medications on fracture healing.

28 Apr 2016

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

27 Apr 2016

Endocrine Society urges physicians to increase screening for primary aldosteronism

The Endocrine Society today issued a Clinical Practice Guideline calling on physicians to ramp up screening for primary aldosteronism, a common cause of high blood pressure.

27 Apr 2016

Clinical inertia puts Type 2 diabetes patients at further risk of preventable complications

People with Type 2 diabetes are being 'let down' because they are being forced to wait for further treatment when needed.

26 Apr 2016

Study reveals how visceral fat contributes to insulin resistance, inflammation

Researchers have long-known that visceral fat - the kind that wraps around the internal organs - is more dangerous than subcutaneous fat that lies just under the skin around the belly, thighs and rear. But how visceral fat contributes to insulin resistance and inflammation has remained unknown.

26 Apr 2016

Salk scientists reveal how cellular fuel gauge plays unexpected role in development

Salk scientists have revealed how a cellular "fuel gauge" responsible for monitoring and managing cells' energy processes also has an unexpected role in development. This critical link could help researchers better understand cancer and diabetes pathways.

26 Apr 2016

Innovative strategy can reverse symptoms in neurodegenerative diseases

Alzheimer's and Parkinson's disease are the two most common neurodegenerative disorders worldwide and cause untold suffering to millions of patients and their families. Treatments for these diseases are limited, and no cures exist. Now, a new study describes an innovative strategy that reverses symptoms in these neurodegenerative diseases - at least in fruit flies which had been genetically altered to model the diseases.

26 Apr 2016

$Study finds TBS as independent contributor to fracture risk assessment$

Study finds TBS as independent contributor to fracture risk assessment

One of the most recent and extensively studied determinants of fracture risk is trabecular bone score (TBS). TBS, which is assessed by lumbar spine dual-energy X-ray absorptiometry (DXA) imaging, provides information about the micro-architectural deterioration of bone tissue. Previous studies have shown that TBS predicts fracture in postmenopausal women and older men. TBS is currently used in conjunction with BMD values to enhance the predictive ability of the widely used Fracture Risk Assessment tool (FRAX), a calculator used to assess an individual's 10-year risk of major osteoporotic fracture.

26 Apr 2016

Study identifies risk factors for asparaginase-induced pancreatitis in ALL patients

Researchers have identified a rare genetic variation associated with a dramatically increased risk of severe acute pancreatitis in acute lymphoblastic leukemia (ALL) patients treated with the chemotherapy agent asparaginase. St. Jude Children's Research Hospital led the study, which appears today in the Journal of Clinical Oncology.

26 Apr 2016

Fructose common in western diet can damage brain genes

A range of diseases -- from diabetes to cardiovascular disease, and from Alzheimer's disease to attention deficit hyperactivity disorder -- are linked to changes to genes in the brain. A new study by UCLA life scientists has found that hundreds of those genes can be damaged by fructose, a sugar that's common in the Western diet, in a way that could lead to those diseases.

25 Apr 2016

Modulation of estrobolome may help lower breast cancer risk

Investigating disparities in the composition of the estrobolome, the gut bacterial genes capable of metabolizing estrogens in both healthy individuals and in women diagnosed with estrogen-driven breast cancer may lead to the development of microbiome-based biomarkers that could help mitigate the risk of certain cancers, according to a review paper published April 22 in the JNCI: Journal of the National Cancer Institute.

25 Apr 2016

Sleep loss influences cholesterol metabolism, study finds

Lack of sleep has previously been found to impact the activation of the immune system, inflammation, carbohydrate metabolism and the hormones that regulate appetite. Now University of Helsinki researchers have found that sleep loss also influences cholesterol metabolism.

22 Apr 2016

Assessing body composition may help predict cardiovascular and total mortality

Researchers from the David Geffen School of Medicine at UCLA found that cardiovascular disease patients who have high muscle mass and low fat mass have a lower mortality risk than those with other body compositions. The findings also suggest that regardless of a person's level of fat mass, a higher level of muscle mass helps reduce the risk of death.

22 Apr 2016

Researchers find new insights on disease stages for gastric cancer patients

Diagnosis of gastric cancer in the early stages is difficult because of the lack of simple and cheap methods of inspection and specific markers of gastric cancer while the symptoms of the disease are vague and tend to overlap with other common and benign conditions. Better tumor characterization and more individualized treatment planning can be expected only with the implementation of better diagnostic tools combined with advances in molecular and genetic analysis.

21 Apr 2016

Low levels of 25-hydroxyvitamin D highly prevalent among children with type 1 diabetes

During the past two decades, vitamin D status, defined as serum concentration of 25-hydroxyvitamin D, has emerged as a predictor of key clinical outcomes including bone health, glucose metabolism, cardiovascular health, immune health and survival.

21 Apr 2016

Metabolism News and Research

Latest Metabolism News and Research

Understanding how individuals respond to aspirin

Nicotine metabolism linked with chronic alcohol abuse may contribute to poor smoking cessation rates

Study links age-related changes in human pancreas to diabetes development

Researchers report tumors can continue to grow even without supply of new blood vessels

Probiotic supplements may help treat post-menopausal osteoporosis

Multidisciplinary experts assess effects of osteoporosis drugs on fracture healing

Rapamycin drug could target neural damage linked to Leigh syndrome

Endocrine Society urges physicians to increase screening for primary aldosteronism

Clinical inertia puts Type 2 diabetes patients at further risk of preventable complications

Study reveals how visceral fat contributes to insulin resistance, inflammation

Salk scientists reveal how cellular fuel gauge plays unexpected role in development

Innovative strategy can reverse symptoms in neurodegenerative diseases

Study finds TBS as independent contributor to fracture risk assessment

Study identifies risk factors for asparaginase-induced pancreatitis in ALL patients

Fructose common in western diet can damage brain genes

Modulation of estrobolome may help lower breast cancer risk

Sleep loss influences cholesterol metabolism, study finds

Assessing body composition may help predict cardiovascular and total mortality

Researchers find new insights on disease stages for gastric cancer patients

Low levels of 25-hydroxyvitamin D highly prevalent among children with type 1 diabetes

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting