Metabolism News and Research

Latest Metabolism News and Research

2014 Canadian Prix Galien for Innovative Product Award presented to Esbriet (pirfenidone)

This year's prestigious Canadian Prix Galien for Innovative Product Award has been presented to Esbriet (pirfenidone), a medicine used to treat idiopathic pulmonary fibrosis (IPF). It is the only medication approved in Canada with a specific IPF indication and is approved for mild to moderate IPF in adults.

21 Nov 2014

Changes in lipid layer of tear film may contribute to contact lens discomfort

Changes in the lipid layer of the eyes' natural tear film may contribute to the common problem of contact lens discomfort, reports a study in the December issue of Optometry and Vision Science, official journal of the American Academy of Optometry.

21 Nov 2014

Aequus Pharmaceuticals closes $4.2M private placement offering of special warrants

Aequus Pharmaceuticals Inc. (the "Company" or "Aequus") is pleased to announce that it has closed a brokered private placement offering (the "Brokered Offering") of special warrants for approximately C$3.7 million.

21 Nov 2014

Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

It has long been known that astrocytes change their shapes as a consequence of Alzheimer's. Cells located near the "plaques", as the protein deposits typical for this disease are called, grow in size and form additional extensions.

20 Nov 2014

Gene therapy transforms life for men with severe form of hemophilia B

Gene therapy developed at St. Jude Children's Research Hospital, University College London and the Royal Free Hospital has transformed life for men with a severe form of hemophilia B by providing a safe, reliable source of the blood clotting protein Factor IX that has allowed some to adopt a more active lifestyle, researchers reported.

19 Nov 2014

Janssen announces submission of NDA for three-month paliperidone palmitate

Janssen Research & Development, LLC today announced the submission of a New Drug Application (NDA) for three-month atypical antipsychotic paliperidone palmitate to the U.S. Food and Drug Administration. The NDA seeks approval for the medication as a treatment for schizophrenia in adults.

19 Nov 2014

Early sodium supplementation improves weight gain in premature infants

Early sodium supplementation for very premature infants can enhance weight gain according to a recent study by researchers at the University of Cincinnati Medical Center and Cincinnati Children's Hospital Medical Center.

18 Nov 2014

New research suggests potential role for MEK inhibitors in type 2 diabetes

A research team led by Brigham and Women's Hospital and Dana-Farber Cancer Institute has uncovered surprising new findings that underscore the role of an important signaling pathway, already known to be critical in cancer, in the development of type 2 diabetes.

18 Nov 2014

Drug combination shows promise in patients with newly diagnosed multiple myeloma

The investigational drug ixazomib taken orally in combination with lenalidomide and dexamethasone shows promise in patients with newly diagnosed multiple myeloma, according to the results of a phase 1/2 study published in the journal Lancet Oncology.

18 Nov 2014

Research finding points to potential new treatment for metabolic disorders

Researchers at the University of Michigan have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders.

17 Nov 2014

New, non-surgical approach to improve sagging skin in the chin and neck region

Patients looking for a non-surgical approach to treat unwanted sagging skin in the chin and neck region have a new and effective option. Bowes Dermatology is proud to offer patients the revolutionary Velashape III to address this common concern.

16 Nov 2014

Cornerstone's CPI-613 drug candidate chosen as 2014 Top 10 Most Interesting Oncology Projects to Watch

Cornerstone Pharmaceuticals, Inc., a development stage company and leader in the growing field of cancer metabolism-based therapeutics, today announced that its lead compound CPI-613 has been chosen by Informa and Kantar Health as one of the 2014 Top 10 Most Interesting Oncology Projects to Watch.

14 Nov 2014

New findings could help develop therapeutic options for glycogen storage disease

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, this inability to process and store glucose can have many different causes, and can be difficult to diagnose.

11 Nov 2014

Five simple steps to reduce type-2 diabetes

There are 29 million U.S. adults diagnosed with diabetes and an additional 1 in 3 diagnosed as pre-diabetic. Diabetes is a serious disease which can result in serious health complications including nerve damage, vision loss, heart disease, and kidney failure, to name a few.

11 Nov 2014

FDA accepts Amgen's evolocumab BLA for review

Amgen today announced that the U.S. Food and Drug Administration has accepted for review Amgen's Biologics License Application (BLA) for evolocumab for the treatment of high cholesterol.

11 Nov 2014

Worst effects of reperfusion injury after heart attack may be prevented with iodide

Blocked arteries are typically the trigger, stopping the flow of blood and starving the heart muscle of oxygen. But when the blockage is removed and the blood comes rushing back, it wreaks havoc of its own. The result is called reperfusion injury, a life-threatening flood of inflammation and cellular destruction that has stumped scientists for 40 years.

9 Nov 2014

New study explains role of cilia in type 2 diabetes

Tiny extensions on cells, cilia, play an important role in insulin release, according to a new study, which is published in Nature Communications. The researchers report that the cilia of beta cells in the pancreas are covered with insulin receptors and that changed ciliary function can be associated with the development of type 2 diabetes.

7 Nov 2014

AZD3965 drug inhibits growth of tumours in the lab

Manchester scientists have shown that a new drug inhibits the growth of tumours in the lab and that its effectiveness is improved by combining it with radiotherapy - suggesting a new approach that could be used in the clinic.

6 Nov 2014

IU School of Medicine researchers identify new protein that can control diabetes

Indiana University School of Medicine researchers have identified a small protein with a big role in lowering plasma glucose and increasing insulin sensitivity.

6 Nov 2014

New research suggests that brain aging can be postponed if placed on a high-fat diet

New Danish-led research suggests that signs of brain aging can be postponed in mice if placed on a high-fat diet. In the long term, this opens the possibility of treatment of children suffering from premature aging and patients with Alzheimer's and Parkinson's disease. The research project is headed by the Center for Healthy Aging, University of Copenhagen and the National Institute of Health.

6 Nov 2014

Metabolism News and Research

Latest Metabolism News and Research

2014 Canadian Prix Galien for Innovative Product Award presented to Esbriet (pirfenidone)

Changes in lipid layer of tear film may contribute to contact lens discomfort

Aequus Pharmaceuticals closes $4.2M private placement offering of special warrants

Special receptor signalling mediates astrocytic hyperactivity in Alzheimer's disease mouse model

Gene therapy transforms life for men with severe form of hemophilia B

Janssen announces submission of NDA for three-month paliperidone palmitate

Early sodium supplementation improves weight gain in premature infants

New research suggests potential role for MEK inhibitors in type 2 diabetes

Drug combination shows promise in patients with newly diagnosed multiple myeloma

Research finding points to potential new treatment for metabolic disorders

New, non-surgical approach to improve sagging skin in the chin and neck region

Cornerstone's CPI-613 drug candidate chosen as 2014 Top 10 Most Interesting Oncology Projects to Watch

New findings could help develop therapeutic options for glycogen storage disease

Five simple steps to reduce type-2 diabetes

FDA accepts Amgen's evolocumab BLA for review

Worst effects of reperfusion injury after heart attack may be prevented with iodide

New study explains role of cilia in type 2 diabetes

AZD3965 drug inhibits growth of tumours in the lab

IU School of Medicine researchers identify new protein that can control diabetes

New research suggests that brain aging can be postponed if placed on a high-fat diet

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