Metabolism News and Research

Latest Metabolism News and Research

A comprehensive overview of stress from neurolobiological and immunological perspective

Stress is one of the most frequently used 'buzz words' across Western societies with an array of meanings ranging from scientifically defined experimental conditions for laboratory animals to a casual word for a nuisance.

18 Jan 2010

MAGIC investigators identify new genetic variants that influence insulin and glucose regulation

An international research consortium has found 13 new genetic variants that influence blood glucose regulation, insulin resistance, and the function of insulin-secreting beta cells in populations of European descent. Five of the newly discovered variants increase the risk of developing type 2 diabetes, the most common form of diabetes.

18 Jan 2010

Researchers identify new gene variants associated With glucose, insulin levels

A major international study with leadership from Massachusetts General Hospital (MGH) researchers has identified 10 new gene variants associated with blood sugar or insulin levels. Two of these novel variants and three that earlier studies associated with glucose levels were also found to increase the risk of type 2 diabetes. Along with a related study from members of the same research consortium, associating additional genetic variants with the metabolic response to a sugary meal, the report will appear in Nature Genetics and has been released online.

18 Jan 2010

Regulus Therapeutics presents new data on oncology, immune disease and HCV therapeutic programs

Regulus Therapeutics Inc. today announced that new pre-clinical data from multiple therapeutic programs were presented at the “RNA Silencing: Mechanism, Biology and Application” Keystone Symposium held January 14 – 19, 2010 in Keystone, Colorado. Regulus and its collaborators presented data showing microRNA target regulation by anti-miRs, as well as data from therapeutic programs focused on oncology, immune disease and hepatitis C virus (HCV) infection.

18 Jan 2010

Researchers uncover novel genetic markers for diabetes-related traits

In two major studies published in Nature Genetics today, researchers use biological understanding to dissect the genetics of diabetes. An international team comprising researchers from more than 100 institutions analysed vast suites of genetic data from more than 100,000 people of European descent to uncover the associations.

18 Jan 2010

Bariatric surgery offers a new hope for obese patients

Obesity is a condition that often follows family lines, but bariatric surgery offers hope for breaking this generational pattern.

18 Jan 2010

Study reveals interaction of genetic and environmental factors in the pathogenesis of Parkinson's disease

"Our study reveals the interaction of genetic and environmental factors such as dietary habits in the pathogenesis of Parkinson's disease," explained Dr. Matthias Elstner of the Neurological Clinic of LMU and Helmholtz Zentrum M-nchen, lead author of the study.

18 Jan 2010

Extended treatment with active ingredient increases bone volume and calcium content

Genta Incorporated today announced publication of two scientific studies that test the active ingredient in Genta’s program to develop orally available gallium-containing compounds and the Company’s marketed product, Ganite® (gallium nitrate for injection).

13 Jan 2010

Research suggests variation of CETP gene is linked to lowered risk of dementia and AD

Preliminary research suggests that variation of a gene for a plasma protein is associated with slower age-related memory decline and a lower risk of dementia and Alzheimer disease (AD), according to a study in the January 13 issue of JAMA.

13 Jan 2010

Researchers identify treatment to reduce health problems associated with enzyme defect

An experimental compound repaired a defective alcohol metabolism enzyme that affects an estimated 1 billion people worldwide, according to research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

10 Jan 2010

Research into "chemical chaperone" may lead to new treatments for heart attacks

Researchers at the Indiana University and Stanford University schools of medicine have determined how a "chemical chaperone" does its job in the body, which could lead to a new class of drugs to help reduce the muscle damage caused by heart attacks.

10 Jan 2010

Key mechanism for systemic delivery of RNAi therapeutics using LNPs discovered

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has discovered a key mechanism related to the systemic delivery of RNAi therapeutics using lipid nanoparticles (LNPs). The new pre-clinical research was presented at the “Advances in Biopharmaceuticals” Keystone Symposium held January 8-13, 2010 in Midway, Utah, and was performed in collaboration with scientists at the Max Planck Institute of Molecular Cell Biology and Genetics.

9 Jan 2010

Immune cells causes inflammation in thyroid-associated ophthalmopathy

A cell type that causes significant scarring in lung disease appears to have a similar effect in Graves' disease, University of Michigan Health System researchers have found. The cells, called fibrocytes, are present at a higher than normal frequency in patients with Graves' disease, according to a new study, the first to associate fibrocytes with this autoimmune disease.

9 Jan 2010

Fibrocytes associated with Graves' disease

9 Jan 2010

A holistic approach to weight loss

When your New Year's resolution to lose weight crumbles as fast as the cookie touching your lips, it's time to admit that diets don't work. More successful is a holistic approach to losing weight that lets you feel good about feeding your body the nourishment it craves.

8 Jan 2010

Zebrafish publishes special issue on cancer biology

The zebrafish, a translucent fish often used as a model of human development and disease, offers unique advantages for studying the cause, growth, and spread of tumors using strategies and methods presented in the current "Cancer Biology" special issue of Zebrafish, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The entire issue is available free online at www.liebertpub.com/zeb

8 Jan 2010

Researchers devise method to pinpoint key genetic variations under positive natural selection that may impact human health

Fossils may provide tantalizing clues to human history but they also lack some vital information, such as revealing which pieces of human DNA have been favored by evolution because they confer beneficial traits - resistance to infection or the ability to digest milk, for example. These signs can only be revealed through genetic studies of modern humans and other related species, though the task has proven difficult.

8 Jan 2010

Proteostasis Therapeutics enters into exclusive license agreement with New York University

Proteostasis Therapeutics announced today that it has entered into an exclusive license agreement with New York University for intellectual property related to discoveries from the laboratory of David Ron, M.D., Professor of Medicine and Julius Raynes Professor of Cell Biology at NYU Langone Medical Center’s Skirball Institute of Biomolecular Medicine.

8 Jan 2010

Young men with HIV infection have coronary atherosclerotic plaques: MGH study

A Massachusetts General Hospital (MGH) study has found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques - some involving serious arterial blockage - than did uninfected men with similar cardiovascular risk.

8 Jan 2010

Balanced diet and exercise are the only reliable ways to lose weight

It's time to set the record straight. The only reliable way to lose weight is to eat less or exercise more. Preferably both.

7 Jan 2010

Metabolism News and Research

Latest Metabolism News and Research

A comprehensive overview of stress from neurolobiological and immunological perspective

MAGIC investigators identify new genetic variants that influence insulin and glucose regulation

Researchers identify new gene variants associated With glucose, insulin levels

Regulus Therapeutics presents new data on oncology, immune disease and HCV therapeutic programs

Researchers uncover novel genetic markers for diabetes-related traits

Bariatric surgery offers a new hope for obese patients

Study reveals interaction of genetic and environmental factors in the pathogenesis of Parkinson's disease

Extended treatment with active ingredient increases bone volume and calcium content

Research suggests variation of CETP gene is linked to lowered risk of dementia and AD

Researchers identify treatment to reduce health problems associated with enzyme defect

Research into "chemical chaperone" may lead to new treatments for heart attacks

Key mechanism for systemic delivery of RNAi therapeutics using LNPs discovered

Immune cells causes inflammation in thyroid-associated ophthalmopathy

Fibrocytes associated with Graves' disease

A holistic approach to weight loss

Zebrafish publishes special issue on cancer biology

Researchers devise method to pinpoint key genetic variations under positive natural selection that may impact human health

Proteostasis Therapeutics enters into exclusive license agreement with New York University

Young men with HIV infection have coronary atherosclerotic plaques: MGH study

Balanced diet and exercise are the only reliable ways to lose weight

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut