Aurigene and Endo’s collaborative efforts yield novel drug candidates

Aurigene and Endo entered into collaboration in 2009, for multiple integrated drug discovery programs in the areas of Inflammation and Oncology.

In one of the programs, a novel selective dual kinase inhibitor, targeting both the antigen receptor signalling and cytokine signalling pathways involved in immune regulation for inflammatory disorders, has been chosen for IND-enabling toxicology studies by Endo.

In a second program, targeting two different growth factor signalling pathways in oncology, a novel class of compounds is being developed, and is in the late lead optimization phase. This program has the potential to deliver multiple candidates for clinical development, targeting several unmet needs for solid tumors.

"We are pleased to be working with a really accomplished and ambitious team at Endo, and these collaborative efforts have enabled us to aim at delivering unique clinical candidates with a profile that is potentially significantly differentiated in the clinic", remarked Dr. Murali Ramachandra , Sr Vice President, Pre-clinical Biology, Aurigene.

"The programs being carried out at Aurigene are an integral part of Endo's strategy to discover novel drug candidates that improve patient outcomes. We are excited about the possibility for the current programs to be important additions to our development pipeline" commented Dr. Sandeep Gupta , Senior Vice President of Drug Discovery and Early Development at Endo.