Metabolism News and Research

Latest Metabolism News and Research

Lipids react and change to bacterial stimulus, trigger cell's immune response

For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell in this case, a mouse macrophage or white blood cell but they also report how these lipids react and change over time to a bacterial stimulus triggering the cell's immune response.

2 Dec 2010

Research may lead to new treatment strategies for Graves' disease

Researchers at the National Institutes of Health have identified a compound that prevents overproduction of thyroid hormone, a finding that brings scientists one step closer to improving treatment for Graves' disease.

2 Dec 2010

Study identifies new genes responsible for early menarche

University of Minnesota School of Public Health researcher Ellen Demerath, Ph.D., is among an international group of researchers that has identified 30 new genes responsible for determining the age of sexual maturation in women. Many of these genes are also known to influence body fatness, obesity, and energy metabolism. Prior to the multi-institutional study, only four genes had been identified as contributing to the process.

1 Dec 2010

Penicillamine challenge ineffective for detecting Wilson's disease in asymptomatic children

An Italian research team confirmed that the scoring system for Wilson's disease (WD) provides good diagnostic accuracy with 93% positive and 92% negative predictive values, respectively in children with mild liver disease. In asymptomatic children, a urinary copper excretion above 40 μg/24 hours was suggestive of WD, however the penicillamine challenge test (PCT) did not provide an accurate diagnosis in this patient subset.

1 Dec 2010

New findings on folic acid supplementation reveal causes of low birth weight

Groundbreaking work by a team of UK scientists has identified, for the first time, a link between changes in the DNA of newborn babies, folic acid supplementation during pregnancy, and birth weight.

1 Dec 2010

Diabetes plays a vital role in regulating brain cholesterol: Research

The brain contains more cholesterol than any other organ in the body, has to produce its own cholesterol and won't function normally if it doesn't churn out enough. Defects in cholesterol metabolism have been linked with Alzheimer's disease and other neurodegenerative conditions. Now researchers at Joslin Diabetes Center have discovered that diabetes can affect how much cholesterol the brain can make.

1 Dec 2010

Fourteen research projects on population health intervention receive $2.8 million

Fourteen research projects on population health intervention research received $2.8 million in funding. The Vice-President of Research at the Canadian Institutes of Health Research (CIHR), Dr. Pierre Chartrand today announced these initiatives during the Population Health Intervention Research Symposium in Toronto.

1 Dec 2010

Research could lead to new drug treatment for metabolic diseases

A team of Harvard School of Public Health (HSPH) scientists report finding a molecular "switch" that can "turn off" some cellular processes that are protective against aging and metabolic diseases. While more research is needed, the findings may open doors for new drug treatments to halt or slow development of metabolic diseases like type 2 diabetes or heart disease. The research findings appear in the December 1, 2010 issue of Cell Metabolism.

1 Dec 2010

Vitamin D supplementation may reduce risk of diabetes, heart disease: Research

Researchers from the UC Davis Health System have found that compared with healthy controls, blood levels of vitamin D are significantly reduced in patients in the Sacramento area with metabolic syndrome, a constellation of disease risk factors that affects about one in three U.S. adults and predisposes them to diabetes, heart disease and stroke.

1 Dec 2010

Angptl4 protein deficiency could promote inflammatory response in people who consume high saturated fat

A new report in the December Cell Metabolism identifies a protein without which diets high in saturated fat lead to a massive inflammatory response that can prove fatal. The studies in mice suggest that deficiencies in this protective pathway could promote inflammation in those who regularly consume high levels of saturated fat.

1 Dec 2010

Mitochondrial dysfunction observed in children with full syndrome autism

Preliminary research has found that children with autism are more likely to have impaired mitochondrial function (structures within cells responsible for energy production) and mitochondrial DNA abnormalities than typically developing children, according to a study in the December 1 issue of JAMA.

1 Dec 2010

Age-related hearing loss associated with low serum levels of folic acid in the elderly

Age-related hearing loss (ARHL), one of the four most prevalent chronic conditions in the elderly, is associated with low serum levels of folic acid, according to new research published in the December 2010 issue of Otolaryngology - Head and Neck Surgery.

1 Dec 2010

Roche NimbleGen announces NewGene as first certified service provider in the UK

Roche NimbleGen announces that Newcastle-based genomic services provider NewGene Ltd. has officially become a Certified Service Provider (CSP) for NimbleGen Sequence Capture. They will provide services for NimbleGen Sequence Capture Arrays with sequencing on the Genome Sequencer FLX System from 454 Life Sciences, a Roche Company.

1 Dec 2010

Scientists create couch potato mouse model to study muscle function

Daniel Kelly, M.D., and his colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) at Lake Nona have unveiled a surprising new model for studying muscle function: the couch potato mouse.

1 Dec 2010

Study finds boosting glucose levels can reduce aggressive behavior

A spoonful of sugar may be enough to cool a hot temper, at least for a short time, according to new research. A study found that people who drank a glass of lemonade sweetened with sugar acted less aggressively toward a stranger a few minutes later than did people who consumed lemonade with a sugar substitute.

1 Dec 2010

BioTrends releases annual syndicated publication of CKD-ND patient charts

BioTrends Research Group, Inc. released ChartTrends: Bone and Mineral Metabolism in Chronic Kidney Disease Non-Dialysis (CKD-ND), an annual syndicated publication based on patient and laboratory data collected from over 1,000 U.S.

30 Nov 2010

Researchers conduct real-time metabolic imaging in human patient with prostate tumor

A UCSF research collaboration with GE Healthcare has produced the first results in humans of a new technology that promises to rapidly assess the presence and aggressiveness of prostate tumors in real time, by imaging the tumor's metabolism.

30 Nov 2010

New tool to trace metabolism of carotenoids in human body

The University of Illinois scientists who linked eating tomatoes with a reduced risk of prostate cancer have developed a tool that will help them trace the metabolism of tomato carotenoids in the human body. And they've secured funding from the National Institutes of Health to do it.

30 Nov 2010

Transgenomic signs definitive agreement to acquire diagnostic business of Clinical Data

Transgenomic, Inc. announced today the signing of a definitive agreement for Transgenomic to acquire the diagnostic business of Clinical Data, Inc. This acquisition includes a suite of proprietary genetic commercial tests, certain proprietary biomarker assays, and the CLIA-certified laboratory operations of Clinical Data for a purchase price of approximately $15.4 million, primarily in cash and notes.

29 Nov 2010

Merck announces initial results from ISENTRESS Phase III study in HIV-1

Merck today reported initial results from the Phase III study investigating the efficacy and safety of a treatment regimen including ISENTRESS® (raltegravir) Tablets once daily in treatment-naïve adult patients infected with HIV-1. ISENTRESS is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-naïve and treatment-experienced adults.

29 Nov 2010

Metabolism News and Research

Latest Metabolism News and Research

Lipids react and change to bacterial stimulus, trigger cell's immune response

Research may lead to new treatment strategies for Graves' disease

Study identifies new genes responsible for early menarche

Penicillamine challenge ineffective for detecting Wilson's disease in asymptomatic children

New findings on folic acid supplementation reveal causes of low birth weight

Diabetes plays a vital role in regulating brain cholesterol: Research

Fourteen research projects on population health intervention receive $2.8 million

Research could lead to new drug treatment for metabolic diseases

Vitamin D supplementation may reduce risk of diabetes, heart disease: Research

Angptl4 protein deficiency could promote inflammatory response in people who consume high saturated fat

Mitochondrial dysfunction observed in children with full syndrome autism

Age-related hearing loss associated with low serum levels of folic acid in the elderly

Roche NimbleGen announces NewGene as first certified service provider in the UK

Scientists create couch potato mouse model to study muscle function

Study finds boosting glucose levels can reduce aggressive behavior

BioTrends releases annual syndicated publication of CKD-ND patient charts

Researchers conduct real-time metabolic imaging in human patient with prostate tumor

New tool to trace metabolism of carotenoids in human body

Transgenomic signs definitive agreement to acquire diagnostic business of Clinical Data

Merck announces initial results from ISENTRESS Phase III study in HIV-1

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