Metabolism News and Research

Latest Metabolism News and Research

Paper discussing the mechanism of the selective TGR5 agonist INT-777 published in Cell Metabolism

Bile acids are known to be key regulators of lipid, glucose and overall energy metabolism. Bile acid activation of the G protein-coupled receptor TGR5 has been shown to induce energy expenditure in muscle and brown fat, thereby conferring resistance to weight gain.

2 Sep 2009

High-density lipoprotein cholesterol concentrations increased in patients treated with LIVALO

New data presented today showed that in patients treated with LIVALO (pitavastatin), high-density lipoprotein cholesterol (HDL-C) concentrations increased, and nearly three-fourths of patients attained low-density lipoprotein cholesterol (LDL-C) targets, with results sustained over 52 weeks.

2 Sep 2009

Weight-loss surgery prior to pregnancy results in lower prevalence of obesity in children

Adolescent and young children of obese mothers who underwent weight-loss surgery prior to pregnancy have been found to have a lower prevalence of obesity and significantly improved cardio-metabolic markers when compared to siblings born before the same obese mothers had weight-loss surgery. This new study has been accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

1 Sep 2009

New study reveals that moderate aerobic exercise improves insulin sensitivity in obese adolescents

A moderate aerobic exercise program, without weight loss, can improve insulin sensitivity in both lean and obese sedentary adolescents, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Insulin is a hormone produced in the pancreas that permits glucose to enter cells to be used for energy or stored for future use by the body.

1 Sep 2009

NASDAQ Stock Market issues noncompliance letter to Encorium Group

Encorium Group, Inc. (Nasdaq: ENCO), a full service multinational clinical research organization (CRO) conducting studies in over 30 countries for many of the world's leading pharmaceutical and biotechnology companies, today announced that on August 25, 2009, it received a letter from The NASDAQ Stock Market notifying the Company that, based on its Form 10-Q for the period ended June 30, 2009, NASDAQ has determined that the Company's stockholders' equity does not comply with the minimum $2.5 million stockholders' equity requirement for continued listing on The NASDAQ Capital Market as required by NASDAQ Marketplace Rule 5550(b)(1).

1 Sep 2009

Study provides insights into genes that help maintain youthfulness of the skin

In the new print issue of Nature Genetics, scientists in Singapore and Germany report that mutations in the PYCR1 gene cause the rare genetic condition that results in premature skin aging and that is known as "wrinkly skin syndrome."

1 Sep 2009

FDA approves the usage of Valcyte for preventing CMV disease in pediatric patients

Roche announced today that the U.S. Food and Drug Administration (FDA) has approved Valcyte(R) (valganciclovir hydrochloride) for the prevention of cytomegalovirus (CMV) disease in pediatric kidney and heart transplant patients (4 months to 16 years of age) at high risk of developing CMV disease.

31 Aug 2009

Springer signs agreement with The Endocrine Society to co-publish a new journal

Springer, one of the leading publishers in the fields of science, technology and medicine, has signed an agreement with The Endocrine Society to co-publish a new journal, Hormones & Cancer, starting in January 2010.

28 Aug 2009

Fatostatin lowers the activity of genes associated with cholesterol synthesis

A small molecule earlier found to have both anti-fat and anti-cancer abilities works as a literal turnoff for fat-making genes, according to a new report in the August 28th issue of the journal Chemistry and Biology, a Cell Press journal.

27 Aug 2009

Rutgers University Professor receives $3.5 million MERIT Award from NIH

Rutgers University Professor Dipak Sarkar has received a $3.5 million MERIT Award from the National Institutes of Health (NIH) to continue researching the damaging effects of alcohol on the nervous systems of the unborn.

27 Aug 2009

Waters exhibits the SYNAPT G2 system at the 18th International Mass Spectrometry Conference in Europe

Waters Corporation (NYSE: WAT) today exhibited for the first time in Europe the Waters((R)) SYNAPT(TM) G2 a system offering scientists greater power, versatility and speed at the 18(th) International Mass Spectrometry Conference (IMSC). Rounding out its display of mass spectrometry (MS) and UltraPerformance Liquid Chromatography (UPLC((R)))/MS systems at IMSC will be Waters Xevo(TM) family of tandem quadrupole and time-of-flight mass spectrometers noted for their ease-of-use and versatility.

27 Aug 2009

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

The extent to which protein targets are modulated by drugs or small molecule compounds depends on a number of factors, including the expression levels of the target, the effective concentration of the compound, and the time needed for the compound to perturb the target. To address these restrictions, researchers Abassi et al. (1) have devised a live cell morphological profiling approach for dynamic monitoring of the effect of small molecule compounds that was based on impedance measurement of cells with the xCELLigence RTCA System of Roche Applied Science.

27 Aug 2009

Study finds that some people eliminate more than 90 percent of the arsenic consumed in the diet

Large variations exist in peoples' ability to eliminate arsenic from the body, according to a new study that questions existing standards for evaluating the human health risks from the potentially toxic substance.

27 Aug 2009

Research study indicates that liver regeneration could affect the metabolism of tacrolimus in LDLT

Several studies have shown that living donor liver transplant (LDLT) recipients required smaller doses of tacrolimus compared with deceased donor liver transplant (DDLT) patients, which indicated that liver regeneration could affect the metabolism of tacrolimus in LDLT.

27 Aug 2009

Angeion Corporation announces financial results for third-quarter fiscal 2009

For the 2009 third quarter, Angeion posted a net loss of $173,000, or $0.04 per diluted share, on revenues of $6.2 million. This represents a sequential improvement from a 2009 second-quarter net loss of $225,000, or $0.05 per diluted share, also on revenues of $6.2 million.

27 Aug 2009

Patients with Phenylketonuria face increased risk of developing severe neurological complications

Genetic researchers at Children's Memorial Hospital, Chicago, are aggressively identifying adult patients who suffer from the genetic disorder, Phenylketonuria (PKU), and are presenting those findings at the 11th International Congress of Inborn Errors of Metabolism in San Diego, August 29 through September 2.

26 Aug 2009

Researchers reveal that genes contributing to drug resistance in NSCLC disease could be predicted

The genes that may contribute to drug resistance in non-small cell lung cancer (NSCLC) can be predicted. Researchers writing in the open access journal BMC Cancer found good correlation between genes believed to be involved in drug sensitivity and resistance and actual in vitro chemosensitivity.

26 Aug 2009

Nuvilex launches web site for marketing Last Shot Hangover Remedy

Nuvilex, Inc. (OTC Bulletin Board: NVLX), announces today the launch of its Last Shot Hangover Remedy(TM) ("Last Shot") web site at www.mylastshot.com. The newly released web site offers Nuvilex' customers product and use information, user testimonials, lists upcoming events, and fan page links to Facebook, Twitter, and YouTube social networking sites.

26 Aug 2009

Clinical study results of USANA Health Sciences products published in the Obesity and Weight Management journal

USANA Health Sciences, Inc. announced today that results of a large, third-party clinical study involving USANA products, conducted at the University of Colorado Denver (UCD), have been published in the August 2009 edition of the journal Obesity and Weight Management.

26 Aug 2009

Mid-career scientists receive the 2009 Julie Martin Mid-Career Awards in Aging Research

Charleen T. Chu, MD, PhD, associate professor at the University of Pittsburgh and David M. Sabatini, MD, PhD, associate professor, Massachusetts Institute of Technology, received the 2009 Julie Martin Mid-Career Awards in Aging Research. Sponsored by The Ellison Medical Foundation, the grants provide funding of $550,000 to mid-career scientists whose research has great potential in advancing understanding of basic aging and its impact on age-related diseases.

26 Aug 2009

Metabolism News and Research

Latest Metabolism News and Research

Paper discussing the mechanism of the selective TGR5 agonist INT-777 published in Cell Metabolism

High-density lipoprotein cholesterol concentrations increased in patients treated with LIVALO

Weight-loss surgery prior to pregnancy results in lower prevalence of obesity in children

New study reveals that moderate aerobic exercise improves insulin sensitivity in obese adolescents

NASDAQ Stock Market issues noncompliance letter to Encorium Group

Study provides insights into genes that help maintain youthfulness of the skin

FDA approves the usage of Valcyte for preventing CMV disease in pediatric patients

Springer signs agreement with The Endocrine Society to co-publish a new journal

Fatostatin lowers the activity of genes associated with cholesterol synthesis

Rutgers University Professor receives $3.5 million MERIT Award from NIH

Waters exhibits the SYNAPT G2 system at the 18th International Mass Spectrometry Conference in Europe

Researchers devise a live cell morphological profiling approach using the xCELLigence RTCA System

Study finds that some people eliminate more than 90 percent of the arsenic consumed in the diet

Research study indicates that liver regeneration could affect the metabolism of tacrolimus in LDLT

Angeion Corporation announces financial results for third-quarter fiscal 2009

Patients with Phenylketonuria face increased risk of developing severe neurological complications

Researchers reveal that genes contributing to drug resistance in NSCLC disease could be predicted

Nuvilex launches web site for marketing Last Shot Hangover Remedy

Clinical study results of USANA Health Sciences products published in the Obesity and Weight Management journal

Mid-career scientists receive the 2009 Julie Martin Mid-Career Awards in Aging Research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut