Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Trinity researchers reveal CHD5 protein acts as tumor suppressor in nervous system development

CHD5 has previously been proposed as a tumour suppressor, acting as a brake that prevents healthy cells from developing into cancer cells. But the part played by the protein in healthy tissue, and whether this role is important for its ability to counter tumour growth, has remained largely uncharted.

14 Aug 2013

Proton therapy provides organ-sparing treatment option for children with neuroblastoma

Proton therapy, using high-energy subatomic particles, may offer a precise, organ-sparing treatment option for children with high-risk forms of neuroblastoma. For patients in a new study of advanced radiation treatment, proton therapy spared the liver and kidneys from unwanted radiation, while zeroing in on its target.

14 Aug 2013

X-linked methyl-CpG protein may be potential target for treatment of Parkinson's

X-linked methyl-CpG binding protein 2 plays important role in the regulation of neuronal development, proliferation and maturation, and synaptic regeneration and apoptosis.

13 Aug 2013

Study provides clues to improve treatment of neuroblastoma with suppressor gene

Loss of a gene required for stem cells in the brain to turn into neurons may underlie the most severe forms of neuroblastoma, a deadly childhood cancer of the nervous system, according to a Ludwig Cancer Research study.

13 Aug 2013

Risk for childhood cancer moderately increased among adolescents with major birth defects

A multistate study led by researchers at the University of Utah has revealed that the risk for childhood cancer is moderately increased among children and young adolescents with certain types of major birth defects.

12 Aug 2013

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

Judith Villablanca, MD, of The Saban Research Institute of Children's Hospital Los Angeles, Susan Kreissman, MD, of Duke University Medical Center, and colleagues reported the results of a randomized, phase 3 clinical trial conducted by the Children's Oncology Group examining the effect of selectively removing (purging) tumor cells from blood stem cells before they are transplanted back into patients with high-risk neuroblastoma following high-dose chemotherapy.

25 Jul 2013

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Back in the early 1960s, just before chemotherapy really started to be used, only about 30% of children survived cancer. That was mainly because they had cancers that were amenable to surgery.

24 Jul 2013

Researchers identify mechanism behind pediatric solid tumors

Most of the time, it takes decades of accumulating genetic errors for a tumor to develop. While this explains the general occurrence of cancer in adults, it leaves a gap in understanding of the cause of pediatric tumors.

20 Jul 2013

Kolltan signs research agreement with CHOP for novel therapeutic approaches for neuroblastoma

Kolltan Pharmaceuticals, Inc., a privately held biopharmaceutical company, today announced a license and research agreement with The Children's Hospital of Philadelphia to commence a collaboration with Yaël Mossé, M.D, an internationally recognized clinician and scientist for her work studying the causes and novel therapeutic approaches for the treatment of children diagnosed with neuroblastoma.

18 Jul 2013

TAp73 protein frequently overexpressed in wide range of human tumors

They say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences with p53 and, as suggested by some previous studies, it may function similar to p53 to prevent tumor formation.

17 Jul 2013

Antibodies boost immune system to fight childhood cancer, shows study

Researchers in the Antibody and Vaccine Group have developed two monoclonal antibodies (mAbs) called anti-4-1BB and anti-CD40 and investigated a third called anti-CTLA-4. Each of these antibodies binds to a different target molecule in the immune system, potentially heightening the body's own immune response to cancer.

12 Jul 2013

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Neuroblastomas are pediatric tumors that originate from cells of the embryonic nervous system. The disease can take widely varying clinical courses that range from spontaneous regression to fatal outcomes.

2 Jul 2013

Researchers find a way the body can remove injured axons

Many medical issues affect nerves, from injuries in car accidents and side effects of chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the long wires that transmit signals to other parts of the body, allowing movement, sight and sense of touch, among other vital functions.

10 May 2013

Stem cell transplant regimen to treat neuroblastoma in children appears to be more toxic in US

The stem cell transplant regimen that was commonly used in the United States to treat advanced neuroblastoma in children appears to be more toxic than the equally effective regimen employed in Europe and Egypt, according to a new study to be presented at the 26th annual meeting of the American Society of Pediatric Hematology Oncology in Miami April 24-27.

25 Apr 2013

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

An irregularity within many neuroblastoma cells may indicate whether a neuroblastoma tumor, a difficult-to-treat, early childhood cancer, is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors, Dana-Farber/Children's Hospital Cancer Center scientists will report at the annual meeting of the American Association for Cancer Research in Washington, April 6-10.

10 Apr 2013

Physician-researcher to lead pediatric Dream Team to create new treatments for childhood cancers

A physician-researcher from The Children's Hospital of Philadelphia will lead the first-ever pediatric "Dream Team" solely focused on creating new treatments for the most challenging childhood cancers.

8 Apr 2013

Scientists develop new cancer immunotherapy treatment for children with high-risk solid tumors

Recently, research using adoptive T-cell immunotherapy in blood cancers have shown success, most notably in the case of a seven-year-old girl whose leukemia went into remission using altered T-cells and a disabled HIV virus.

4 Apr 2013

Three institutions partner to create research breakthroughs in children's health

Virginia Tech, Children's National Medical Center, and the George Washington University have partnered in a unique program to create research breakthroughs in children's health.

4 Apr 2013

CHOP expert to receive Pediatric Oncology Award from ASCO

The American Society of Clinical Oncology today announced it will confer one of its highest awards on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children's Hospital of Philadelphia.

16 Mar 2013

Pediatric cancer charities collaborate to create new treatments for children with neuroblastoma

Solving Kids' Cancer, along with U.K.-based charities Neuroblastoma Alliance UK, J-A-C-K, and other European organizations have aligned forces to improve access to promising clinical trials for children with high-risk neuroblastoma in North America, the U.K. and Europe.

5 Mar 2013

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

Trinity researchers reveal CHD5 protein acts as tumor suppressor in nervous system development

Proton therapy provides organ-sparing treatment option for children with neuroblastoma

X-linked methyl-CpG protein may be potential target for treatment of Parkinson's

Study provides clues to improve treatment of neuroblastoma with suppressor gene

Risk for childhood cancer moderately increased among adolescents with major birth defects

Randomized trial examines purging of tumor cells from stem cells prior to transplantation in neuroblastoma patients

Child cancer survival: an interview with Prof Kathy Pritchard-Jones, University College London

Researchers identify mechanism behind pediatric solid tumors

Kolltan signs research agreement with CHOP for novel therapeutic approaches for neuroblastoma

TAp73 protein frequently overexpressed in wide range of human tumors

Antibodies boost immune system to fight childhood cancer, shows study

HDAC10 gene plays a key role in autophagy and resistance to chemotherapy in high-risk neuroblastomas

Researchers find a way the body can remove injured axons

Stem cell transplant regimen to treat neuroblastoma in children appears to be more toxic in US

Tumors with excess copies of MYCN highly sensitive to BET bromodomain inhibitors, researchers find

Physician-researcher to lead pediatric Dream Team to create new treatments for childhood cancers

Scientists develop new cancer immunotherapy treatment for children with high-risk solid tumors

Three institutions partner to create research breakthroughs in children's health

CHOP expert to receive Pediatric Oncology Award from ASCO

Pediatric cancer charities collaborate to create new treatments for children with neuroblastoma

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Empowering genomics research with cloud-based innovation

Neuroblastoma News and Research

Latest Neuroblastoma News and Research

From street to lab: Advancing controlled substance testing with handheld Raman and FTIR

Reimagining light scattering for biotherapeutics

Empowering genomics research with cloud-based innovation

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