Pharmacology News and Research

Latest Pharmacology News and Research

Interleukin-1-beta-induced chronic inflammation promotes lung cancer metastasis

The study reveals a detailed epigenetic mechanism for how interleukin-1-beta, a common cytokine that helps fight infections during inflammation, plays a critical role in cancer metastasis.

29 Jan 2020

Pre-existing anticancer drug could help treat common form of heart failure

When it comes to finding new treatments for disease, reinventing the wheel is not always necessary - drugs already in use for other conditions may do the job.

29 Jan 2020

Study advances the understanding of capillary regression

Many diseases arise from abnormalities in our capillaries, tiny exquisitely branching blood vessel networks that play a critical role in tissue health.

29 Jan 2020

Study on axolotl's ability to regenerate might help find ways to restore damaged tissue in humans

The type of salamander called axolotl, with its frilly gills and widely spaced eyes, looks like an alien and has other-worldly powers of regeneration. Lose a limb, part of the heart or even a large portion of its brain? No problem: They grow back.

28 Jan 2020

Study finds unexpected response to estrogen at the single cell level

A team led by researchers at Baylor College of Medicine found that not only do individual mammalian cells in a population fail to respond synchronously to estrogen stimulation, neither do individual gene copies, known as alleles.

28 Jan 2020

Human organ chips for better drug development

The process of developing new drugs is both difficult and costly. It is estimated that of all the drug candidates which start out on their testing journey, less than 14% actually make it to the clinical scene and receive approval by the US Food and Drug Administration (FDA).

27 Jan 2020

Improving drug testing with comprehensive 'Organ Chip' platform

The U.S. Food and Drug Administration approves only 13.8% of all tested drugs, and these numbers are even lower in "orphan" diseases that affect relatively few people.

27 Jan 2020

A microdose lithium formulation could halt signs of Alzheimer's pathology

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer's disease.

24 Jan 2020

UCI-led study reveals link between early life adversity and opioid addiction

Individuals with a history of early life adversity are disproportionately prone to opioid addiction. A new UCI-led study reveals why.

24 Jan 2020

APRNs have expanded roles in national response to opioid crisis

As we enter a new year and a new decade, many states have enacted legislation affecting the roles of advanced practice registered nurses in terms of practice authority, reimbursement, and prescriptive authority, according to the 32nd Annual Legislative Update in the January issue of The Nurse Practitioner, published by Wolters Kluwer.

24 Jan 2020

Transcriptional scanning in the sperm may regulate rate of human evolution

Maturing sperm cells turn on most of their genes, not to follow their genetic instructions like normal, but instead to repair DNA before passing it to the next generation, a new study finds.

23 Jan 2020

Researchers solve long-standing mystery linked to contraction of heart cells

We've all felt the effects of an adrenaline rush. Faced with danger, real or perceived, the heart beats faster, breathing quickens and muscles tighten as the body prepares to fight a threat or flee from it.

23 Jan 2020

Collaboration reveals promising therapeutic strategy for osteoarthritis

Osteoarthritis affects 240 million people worldwide and is one of the most common causes of disability in both humans and animals.

22 Jan 2020

Study explores ways to stop cell death, induce regeneration to restore vision

Progress in research and technology is giving rise to an optimistic future for compensation and restoration of low vision, according to research in a special issue of Restorative Neurology and Neuroscience, published by IOS Press.

22 Jan 2020

Potential Parkinson's treatment effectively targets a specific group of brain cells

Scientists have discovered that a non-invasive technique which could one day be used to treat Parkinson's disease, can successfully target a highly specific group of brain cells which play a key role in development of the condition.

22 Jan 2020

Sunscreen ingredients absorbed into blood finds study from FDA

A new study has analyzed the amount of sunscreen ingredients that get absorbed into the blood stream via the skin. The study titled, “Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients A Randomized Clinical Trial,” was published in the latest issue of the journal JAMA.

21 Jan 2020

Study finds new strategies for developing cancer drug

After years of research on cell surface receptors called Frizzleds, researchers at Karolinska Institutet in Sweden provide the proof-of-principle that these receptors are druggable by small molecules. The results, which are published in the scientific journal Nature Communications, open for new strategies to treat different types of cancer.

21 Jan 2020