Schizophrenia

Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.

Schizophrenia

Schizophrenia is a chronic mental health disorder that causes people to think, feel and perceive the world differently from the general population.

Schizophrenia Signs and Symptoms

Schizophrenia Screening, Prevention and Management

Schizophrenia Causes

Schizophrenia Diagnosis

Schizophrenia Prognosis

Schizophrenia Mechanisms

Schizophrenia Medication

Schizophrenia Interventions

Schizophrenia Neural Processes

Latest Schizophrenia News and Research

Two scientists win Horwitz Prize for Rett syndrome breakthrough

Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.

2 Sep 2026

Post-trauma mental health conditions increase future cardiovascular risks

Mental health conditions, such as posttraumatic stress disorder (PTSD), substance abuse, depression and anxiety, can develop after people experience trauma.

2 Sep 2026

Bridging science and family story to understand schizophrenia origins

Twin studies have placed the heritability of schizophrenia at roughly eighty percent for decades. Concordance between identical twins, who share the entire genome, does not reach fifty percent. Both figures are well established, and they do not fit together comfortably.

2 Sep 2026

Researchers discover dozens of genes tied to OCD and tic disorders

A Rutgers-led international collaboration has identified 36 genes that substantially raise the risk for obsessive-compulsive disorder (OCD) and chronic tic disorders – providing what two researchers said is the most detailed biological understanding of how these conditions develop – and how they might eventually be treated.

2 Sep 2026

New brain atlas reveals insights into Huntington's, addiction, and other disorders

A region of the brain called the striatum is critical for many cognitive and motor functions, including decision-making, control of movement, habit formation, and processing of reward.

1 Sep 2026

Study identifies 36 risk genes for OCD and tic disorders

1 Sep 2026

Precision psychiatry aims to match schizophrenia patients with tailored medicines

Imagine watching a son or daughter begin college during a formative time in life, only to have schizophrenia suddenly alter their reality.

31 Aug 2026

Does a psychedelic need an awake brain to have lasting effects? This mouse study offers a clue

A single dose of psilocybin produced a lasting increase in sociability for at least two weeks in Cntnap2-knockout mice with social deficits, while it did not enhance sociability overall in mice with normal social behavior. The effect required 5-HT2A receptor activation and persisted when psilocybin was administered under light anesthesia, suggesting that wakefulness during the drug’s acute effects was not necessary for this behavioral response.

30 Aug 2026

Probiotics for mental health? A new review finds promising signals and major gaps

This narrative review examines how psychobiotics may influence anxiety, depression, bipolar disorder, and schizophrenia through gut-brain pathways involving neurotransmitters, inflammation, immune regulation, gut barrier function, and stress signaling. Specific Lactobacillus and Bifidobacterium strains showed encouraging effects, but wide differences in strains, doses, populations, and study designs currently limit clinical translation.

28 Aug 2026

Blood-brain barrier-crossing blood pressure drugs linked to lower dementia risk

In a large Australian cohort of adults with hypertension, use of blood-brain barrier-crossing antihypertensive medications was associated with a lower risk of dementia and mortality than use of non-crossing drugs. The association was strongest for beta-blockers and angiotensin II receptor blockers, although the observational design means the findings cannot establish causality.

27 Aug 2026

Stress gene switches on more easily in the brains of people with schizophrenia

Experts at the University of Sydney have found that a gene involved in regulating the body's response to stress switches on more easily in the brains of people who live with schizophrenia.

26 Aug 2026

Emergency diagnoses of medical conditions predict worse patient survival

Patients diagnosed with conditions after an emergency hospital admission or an emergency room visit face a higher risk of death than those diagnosed in non-emergency settings, according to a large population-based study by Emma Whitfield and colleagues from University College London, UK, published August 25th in the open access journal PLOS Medicine.

25 Aug 2026

Study finds distinct patterns of innate immune activity in mental disorders

The immune system may also play a role in mental disorders. Scientists are investigating these links with brain function in greater detail, and new findings show that immune changes may differ by disorder type.

25 Aug 2026

Oxford study identifies brain mechanisms behind our sense of control

A study led by the University of Oxford has identified the brain mechanisms that help us work out whether the consequences we experience are caused by our own actions or by circumstances beyond our control.

21 Aug 2026

Researchers maintain brain organoids for longer than ever before

An international team of researchers has maintained brain organoids, three-dimensional models of human brain tissue, for longer than ever before.

20 Aug 2026

Skull bone marrow contains immune hubs that fight brain cancer

Researchers at Washington University School of Medicine in St. Louis have discovered lymph node-like structures in the skull bone marrow of mice for the first time and demonstrated that they act as rapid first responders against brain cancer before distant lymph nodes get the signal that abnormal cells are present.

19 Aug 2026

Shifting expectations of unpredictability could help treat schizophrenia delusions

New research has found that improvements to the severity of delusions in patients with schizophrenia-spectrum disorder recovering from an acute psychotic episode were significantly associated with reductions in volatility priors—someone's expectations about the unpredictability of their environment.

18 Aug 2026

Severe mental illness may accelerate dementia and stroke vulnerability

People living with severe mental illness face a substantially higher risk of dementia throughout adulthood, as well as a significantly elevated risk of stroke in early and middle adulthood, according to a large new study based on health records from Catalonia, Spain.

17 Aug 2026

Subtle brain differences detected in children at risk for schizophrenia

A study examined the brains of children at increased risk of developing schizophrenia to determine whether signs of vulnerability can be detected during childhood.

13 Aug 2026

Long-term study highlights ongoing care needs among former CAMHS patients

Four in ten children who attend Child and Adolescent Mental Health Services (CAMHS) in Scotland go on to attend specialist psychiatric services as adults, according to new research.

4 Aug 2026