Scleroderma

Scleroderma is a chronic, often progressive, autoimmune disease in which the body's immune system attacks its own body. The disease, which literally means "hard skin," can cause a thickening and tightening of the skin. In some cases it causes serious damage to internal organs including the lungs, heart, kidneys, esophagus and gastrointestinal tract. Some medicines and treatments can help with certain symptoms, but there is still no cure for scleroderma, which affects about 300,000 nationwide. (By way of comparison, about 50,000 people have muscular dystrophy, 250,000 are estimated to have lupus and 350,000 have multiple sclerosis.)
What is Scleroderma?

Scleroderma, also sometimes referred to as systemic sclerosis, is a chronic autoimmune disorder that involves progressive hardening of the skin. An excess of collagen and other connective tissues in the skin leads to a change in cellular structure and vascular of the tissues. Internal organs may also be affected in more severe cases.

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Overview

Latest Scleroderma News and Research

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Elevated and sustained autoantibodies following COVID-19

Elevated and sustained autoantibodies following COVID-19

Urgent action needed to address disparities in women’s heart health

Urgent action needed to address disparities in women’s heart health

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Gene key to excessive cell proliferation could be a potential target for fatal pulmonary hypertension

Gene key to excessive cell proliferation could be a potential target for fatal pulmonary hypertension

Black patients with systemic sclerosis may experience poorer outcomes more often than others

Black patients with systemic sclerosis may experience poorer outcomes more often than others

Platelet inhibitors may be linked with reduction in digital ulcers in people with systemic sclerosis

Platelet inhibitors may be linked with reduction in digital ulcers in people with systemic sclerosis

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

NIH begins clinical trial to assess extra COVID-19 vaccine dose in people with autoimmune disease

Researchers discover potential biomarker for lung disease in scleroderma patients

Researchers discover potential biomarker for lung disease in scleroderma patients

Online mental health intervention improves anxiety in isolated scleroderma patients during the pandemic

Online mental health intervention improves anxiety in isolated scleroderma patients during the pandemic

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

Repurposing an anti-inflammatory drug can prevent lung disease in patients with systemic sclerosis

New approach can help treat hypertrophic cardiomyopathy with precision medicine

New approach can help treat hypertrophic cardiomyopathy with precision medicine

A protein may be responsible for triggering lung scarring in scleroderma patients

A protein may be responsible for triggering lung scarring in scleroderma patients

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

LOX plays a number of key roles in promoting skin and organ fibrosis in scleroderma

LOX plays a number of key roles in promoting skin and organ fibrosis in scleroderma

Women with interstitial lung disease may not need to terminate their pregnancies

Women with interstitial lung disease may not need to terminate their pregnancies

Translational research training program helps students to better understand patients' problems

Translational research training program helps students to better understand patients' problems

Research uncovers potential cause of neurotoxicity due to immunotherapy

Research uncovers potential cause of neurotoxicity due to immunotherapy