Scleroderma

Scleroderma is a chronic, often progressive, autoimmune disease in which the body's immune system attacks its own body. The disease, which literally means "hard skin," can cause a thickening and tightening of the skin. In some cases it causes serious damage to internal organs including the lungs, heart, kidneys, esophagus and gastrointestinal tract. Some medicines and treatments can help with certain symptoms, but there is still no cure for scleroderma, which affects about 300,000 nationwide. (By way of comparison, about 50,000 people have muscular dystrophy, 250,000 are estimated to have lupus and 350,000 have multiple sclerosis.)
What is Scleroderma?

Scleroderma, also sometimes referred to as systemic sclerosis, is a chronic autoimmune disorder that involves progressive hardening of the skin. An excess of collagen and other connective tissues in the skin leads to a change in cellular structure and vascular of the tissues. Internal organs may also be affected in more severe cases.

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Overview

Latest Scleroderma News and Research

Study sheds wider light on the clinical profile of patients with pulmonary hypertension

Study sheds wider light on the clinical profile of patients with pulmonary hypertension

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

Newly discovered molecule in the lymphatic system could play a role in autoimmune diseases

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

BU researcher receives NIH grant for clinical research in rheumatology

BU researcher receives NIH grant for clinical research in rheumatology

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

Survey says half of people with rheumatoid disease struggle to pay for treatment

Survey says half of people with rheumatoid disease struggle to pay for treatment

Failed cancer drug could potentially be used to treat fibrotic diseases and scleroderma

Failed cancer drug could potentially be used to treat fibrotic diseases and scleroderma

FDA approves first drug to treat patients with rare lung condition

FDA approves first drug to treat patients with rare lung condition

Elevated estrogen levels associated with more severe disease in scleroderma

Elevated estrogen levels associated with more severe disease in scleroderma

Newly identified internal regulator helps control body's response to fight infection

Newly identified internal regulator helps control body's response to fight infection

Finding potential treatments for autoimmune diseases

Finding potential treatments for autoimmune diseases

Suppressing cancer-causing protein could correct increased fibrosis in scleroderma patients

Suppressing cancer-causing protein could correct increased fibrosis in scleroderma patients

MUSC researchers identify potential therapeutic target for lung fibrosis

MUSC researchers identify potential therapeutic target for lung fibrosis

Silicone breast implants may increase risk of rare adverse outcomes in women

Silicone breast implants may increase risk of rare adverse outcomes in women

Study shows B cells could play reciprocal roles in pathogenesis of systemic sclerosis

Study shows B cells could play reciprocal roles in pathogenesis of systemic sclerosis

Scleroderma Foundation names Tulane professor as 'Doctor of the Year'

Scleroderma Foundation names Tulane professor as 'Doctor of the Year'

Seeking solutions to treat scleroderma

Seeking solutions to treat scleroderma

Researchers find experimental compound to treat fibrotic diseases

Researchers find experimental compound to treat fibrotic diseases

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

Improving the Diagnosis of Cardiac Sarcoidosis

Improving the Diagnosis of Cardiac Sarcoidosis