Scleroderma

Scleroderma is a chronic, often progressive, autoimmune disease in which the body's immune system attacks its own body. The disease, which literally means "hard skin," can cause a thickening and tightening of the skin. In some cases it causes serious damage to internal organs including the lungs, heart, kidneys, esophagus and gastrointestinal tract. Some medicines and treatments can help with certain symptoms, but there is still no cure for scleroderma, which affects about 300,000 nationwide. (By way of comparison, about 50,000 people have muscular dystrophy, 250,000 are estimated to have lupus and 350,000 have multiple sclerosis.)
What is Scleroderma?

Scleroderma, also sometimes referred to as systemic sclerosis, is a chronic autoimmune disorder that involves progressive hardening of the skin. An excess of collagen and other connective tissues in the skin leads to a change in cellular structure and vascular of the tissues. Internal organs may also be affected in more severe cases.

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Overview

Latest Scleroderma News and Research

World-first discovery offers potential cure for lupus

World-first discovery offers potential cure for lupus

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

X-chromosome inactivation and its role in autoimmune susceptibility in females

X-chromosome inactivation and its role in autoimmune susceptibility in females

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

Genetic causes of Raynaud’s phenomenon identified

Genetic causes of Raynaud’s phenomenon identified

EULAR releases new recommendations for non-pharmacological management of SLE and SSc

EULAR releases new recommendations for non-pharmacological management of SLE and SSc

Genetic reasons behind Raynaud's phenomenon discovered

Genetic reasons behind Raynaud's phenomenon discovered

Extracellular vesicles may drive fibrosis in scleroderma

Extracellular vesicles may drive fibrosis in scleroderma

Study finds improved survival in patients with SLE-associated PAH

Study finds improved survival in patients with SLE-associated PAH

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children

Proteomics reveals a distinct IFN-driven plasma cytokine response to COVID-19 in infants and young children

Wearable activity tracker data can be used to obtain metrics associated with user's physical health

Wearable activity tracker data can be used to obtain metrics associated with user's physical health

RIT professor receives grant to investigate new therapeutic approaches for scleroderma

RIT professor receives grant to investigate new therapeutic approaches for scleroderma

Patients with scleroderma have reduced levels of Cathepsin L

Patients with scleroderma have reduced levels of Cathepsin L

Study identifies mechanism behind 'cytokine storm' in COVID-19 patient lungs

Study identifies mechanism behind 'cytokine storm' in COVID-19 patient lungs

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Elevated and sustained autoantibodies following COVID-19

Elevated and sustained autoantibodies following COVID-19

Urgent action needed to address disparities in women’s heart health

Urgent action needed to address disparities in women’s heart health

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

A critical subset of fibroblasts may lie at the origins of rare autoimmune disease

Biodegradable nanoparticle used in medical sutures could help combat scleroderma

Biodegradable nanoparticle used in medical sutures could help combat scleroderma