Sickle Cell Disease

Sickle-cell disease, or sickle-cell anaemia (or drepanocytosis), is a life-long blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications.

Understanding Sickle Cell Disease

World Sickle Cell Day is June 19 and was created by the United Nations in 2006 to raise global awareness for sickle cell disease as a public health problem. Sickle cell disease is an extremely debilitating medical condition.

What is Sickle-Cell Disease?

Sickle-Cell Disease Classification

Sickle Cell Disease Diagnosis

Sickle-Cell Disease Pathophysiology

Sickle-Cell Disease Genetics

Sickle-Cell Disease Treatment

Sickle-Cell Disease History

Sickle Cell Disease Carriers

Sickle-Cell Disease Symptoms

What is Sickle Cell Trait (SCT)?

Treatment Options for Sickle Cell Disease

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COVID-19 and Sickle Cell Disease

Current Challenges in Sickle Cell Disease

Latest Sickle Cell Disease News and Research

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.

19 Jul 2021

Most states did not use health equity committees to assist with COVID-19 vaccine distribution planning

During the large second wave of the COVID-19 pandemic in fall 2020, pulmonologist and critical care provider Juan C. Rojas, MD, reflected on how disproportionately members of minority populations were being affected by the disease.

2 Jul 2021

Citizens’ jury set to reflect deeply on the pros and cons of human genome editing

Two dozen ‘ordinary Aussies’ tackle whether scientists should be able to change our genes to prevent disease or create superhumans

17 Jun 2021

Global blood centers join hands to develop more efficient, accurate blood typing technology

Blood centers from around the world have united to form an international collaboration with academic research institutions and a leading genomic array company, Thermo Fisher Scientific, to deliver a technology which promises to make the future of blood transfusion therapy more efficient, cost-effective, accurate, standardized, and safer.

17 Jun 2021

UCSF launches new initiative to propel the development of living therapeutics

UC San Francisco is launching a new initiative to propel the development of living therapeutics - a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease - and bring them quickly to patients.

14 Jun 2021

Johns Hopkins researcher receives prestigious award for breakthrough research in circadian science

Sleep medicine physician and sleep researcher Dr. Charlene Gamaldo of Johns Hopkins Medicine is the recipient of the inaugural Diversity, Equity and Inclusion Leadership Award from the Associated Professional Sleep Societies, LLC, a joint initiative of the American Academy of Sleep Medicine and the Sleep Research Society.

11 Jun 2021

Pitt researchers use a unique and powerful MRI device to study sickle cell disease

Sickle Cell Disease (SCD) is a genetically inherited group of red blood cell disorders. According to the CDC, an estimated 90,000 to 100,000 people in the United States live with this disease, and it disproportionately affects Black or African Americans; it occurs in roughly 1 in every 500 individuals in this demographic.

3 Jun 2021

Researchers develop proof-of-concept treatment for blood disorders

Researchers at Children's Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin.

1 Jun 2021

New technique can help to non-invasively assess progression of sickle cell retinopathy

Ophthalmologists at New York Eye and Ear Infirmary of Mount Sinai have created a new technique to evaluate patients with sickle cell retinopathy and assess the disease before it progresses and leads to permanent vision loss.

10 May 2021

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

St. Jude Children's Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics.

7 May 2021

California and Texas took different routes to vaccination. Who’s ahead?

California and Texas, the country's two most populous states, have taken radically different approaches to the pandemic and the vaccination campaign to end it.

22 Apr 2021

Toward a transformative therapy for sickle cell patients

For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms.

9 Apr 2021

Adaptive cognitive training program can benefit children with sickle cell disease

An adaptive cognitive training program could help treat attention and working memory difficulties in children with sickle cell disease (SCD), a new study published in the of Journal of Pediatric Psychology shows.

9 Apr 2021

Prime editing enables more precise correction of genetic problems than traditional CRISPR

The latest gene editing technology, prime editing, expands the "genetic toolbox" for more precisely creating disease models and correcting genetic problems, scientists say.

30 Mar 2021

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells.

30 Mar 2021

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

UT Southwestern researchers have identified factors that put patients with childhood-onset lupus at elevated risk for poor outcomes, such as end-stage renal disease or death, as they transition from pediatric to adult health care.

30 Mar 2021

Research could lead to a personalized approach for treating sickle cell disease

Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research.

24 Mar 2021

Sickle Cell Disease

Overview

What is Sickle-Cell Disease?

Sickle-Cell Disease Classification

Sickle Cell Disease Diagnosis

Feature Articles

Sickle-Cell Disease Pathophysiology

Sickle-Cell Disease Genetics

Sickle-Cell Disease Treatment

Sickle-Cell Disease History

Sickle Cell Disease Carriers

Sickle-Cell Disease Symptoms

What is Sickle Cell Trait (SCT)?

Treatment Options for Sickle Cell Disease

COVID-19 and Sickle Cell Disease

Current Challenges in Sickle Cell Disease

Latest Sickle Cell Disease News and Research

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

Most states did not use health equity committees to assist with COVID-19 vaccine distribution planning

Citizens’ jury set to reflect deeply on the pros and cons of human genome editing

Global blood centers join hands to develop more efficient, accurate blood typing technology

UCSF launches new initiative to propel the development of living therapeutics

Johns Hopkins researcher receives prestigious award for breakthrough research in circadian science

Pitt researchers use a unique and powerful MRI device to study sickle cell disease

Researchers develop proof-of-concept treatment for blood disorders

New technique can help to non-invasively assess progression of sickle cell retinopathy

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

California and Texas took different routes to vaccination. Who’s ahead?

Toward a transformative therapy for sickle cell patients

Adaptive cognitive training program can benefit children with sickle cell disease

Prime editing enables more precise correction of genetic problems than traditional CRISPR

Scientists launch clinical trial of CRISPR gene correction therapy in patients with sickle cell disease

Researchers identify factors linked to poor outcomes in patients with childhood-onset lupus

Research could lead to a personalized approach for treating sickle cell disease

People with high BMI may now receive their COVID-19 vaccine in California

Combined liver-cytokine humanization enhances human red blood cell production and survival

A single letter difference in a single gene spells a lifetime of anemia, pain worldwide

World Brain Day 2021: An interview with Professor Alan Thompson

Preventing lethal blood clots

Curbing COVID-19 through border controls and restricted entry

Sickle Cell Disease

Overview

Feature Articles

Sickle-Cell Disease Pathophysiology

Sickle-Cell Disease Genetics

Sickle-Cell Disease Treatment

Sickle-Cell Disease History

Sickle Cell Disease Carriers

Sickle-Cell Disease Symptoms

What is Sickle Cell Trait (SCT)?

Treatment Options for Sickle Cell Disease

COVID-19 and Sickle Cell Disease

Current Challenges in Sickle Cell Disease

Latest Sickle Cell Disease News and Research

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