Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

SARS-CoV-2 protein linked to onset of multisystem inflammatory syndrome in children

St. Jude Children's Research Hospital scientists have identified a link between a SARS-CoV-2 protein and the onset of multisystem inflammatory syndrome in children (MIS-C).

7 Aug 2024

Understanding the age gap in leukemia survival rates

Acute lymphoblastic leukemia (ALL) affects both children and adults, but children have better chances to be cured, with long-term survival rates over 85% compared to 50-75% in adults. Scientists at St. Jude Children's Research Hospital conducted a comprehensive study to understand the biological causes driving this difference. The work, published today in the Journal of Clinical Oncology, provides a blueprint for understanding B-cell acute lymphoblastic leukemia (B-ALL), the most common form of the disease.

7 Aug 2024

Study advances understanding of complex neurological disorder

To effectively treat a disease or disorder, doctors must first know the root cause. Such is the case for developmental and epileptic encephalopathies (DEEs), whose root causes can be hugely complex and heterogeneous. Scientists at St. Jude Children's Research Hospital demonstrated the value of DNA methylation patterns for identifying the root cause of DEEs, showing specific gene methylation and genome-wide methylation "episignatures" can help identify the genes that cause DEE. The findings were published today in Nature Communications.

7 Aug 2024

Enhanced CAR T-cell homing boosts treatment efficacy for osteosarcoma

Chimeric antigen receptor (CAR) T–cell immunotherapy re-engineers a patient's immune cells to target cancer cells.

5 Aug 2024

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for >90% of pediatric cancer patients by sequencing 0.15% of the human genome.

1 Aug 2024

Study reveals serotonin's role in ependymoma tumor growth

Do neurons play a role in brain tumor growth and development? Scientists at St. Jude Children's Research Hospital and Baylor College of Medicine have evidence showing that, for childhood ependymomas, they do.

31 Jul 2024

Study: Iron infusions superior to blood transfusions for surgical patients with anemia

In a rigorous medical records study covering tens of thousands of patients, Johns Hopkins Medicine researchers conclude that some patients with preoperative anemia have better outcomes if they get iron infusions before surgery rather than standard red blood cell transfusions.

25 Jul 2024

Ovarian reserve unchanged by hydroxyurea in sickle cell disease, study reveals

In female patients living with sickle cell disease (SCD), hydroxyurea had no effect on ovarian reserve, suggesting that fertility preservation measures prior to treatment may be unnecessary, according to a study published in Blood Advances.

18 Jul 2024

Swift transfer from pediatric to adult care may reduce the use of acute care services in sickle cell disease

Sickle cell disease is the most common inherited red blood cell disorder in the United States and can lead to health problems including organ dysfunction, acute chest syndrome and strokes over a patient's lifespan.

16 Jul 2024

UCLA study finds insomnia drug suvorexant prevents opioid addiction in mice

New research led by UCLA Health has found a drug that treats insomnia works to prevent the addictive effects of the morphine opioids in mice while still providing effective pain relief.

9 Jul 2024

Understanding patient distress in sickle cell disease

While distress is well-documented in patients with sickle cell disease, sources of distress and how patients manage distress have not been well explored.

9 Jul 2024

Decoding the viscoelastic properties of biomolecular condensates

Biomolecular condensates are membraneless hubs of condensed proteins and nucleic acids within cells, which researchers are realizing are tied to an increasing number of cellular processes and diseases.

2 Jul 2024

New curative treatment for sickle cell disease shows promising results in international trial

Vanderbilt University Medical Center (VUMC) researchers are touting data from a multicenter, international phase 2 clinical trial showing a new, curative treatment for sickle cell disease (SCD).

25 Jun 2024

Promising gene editing therapy shows hope in sickle cell disease cure

Researchers have presented the latest findings from a clinical trial aimed at discovering a cure for sickle cell disease, a painful genetic blood disorder with limited treatment options.

14 Jun 2024

St. Jude researchers uncover NLRC5's role in immune response and cell death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

14 Jun 2024

How tight binding between immune cells dictates T cell cancer-fighting ability

Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.

30 May 2024

Timely transition from pediatric to adult care reduces hospitalizations for sickle cell patients

Individuals living with sickle cell disease (SCD) who experience a delay of more than six months in transitioning from pediatric to adult care are twice as likely to be hospitalized compared to those who transition in less than two months, according to a study published in Blood Advances.

29 May 2024

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

SARS-CoV-2 protein linked to onset of multisystem inflammatory syndrome in children

Understanding the age gap in leukemia survival rates

Study advances understanding of complex neurological disorder

Enhanced CAR T-cell homing boosts treatment efficacy for osteosarcoma

St. Jude develops cost-effective genetic panel for pediatric cancer diagnosis

Study reveals serotonin's role in ependymoma tumor growth

Study: Iron infusions superior to blood transfusions for surgical patients with anemia

Ovarian reserve unchanged by hydroxyurea in sickle cell disease, study reveals

Swift transfer from pediatric to adult care may reduce the use of acute care services in sickle cell disease

UCLA study finds insomnia drug suvorexant prevents opioid addiction in mice

Understanding patient distress in sickle cell disease

Decoding the viscoelastic properties of biomolecular condensates

New curative treatment for sickle cell disease shows promising results in international trial

Promising gene editing therapy shows hope in sickle cell disease cure

St. Jude researchers uncover NLRC5's role in immune response and cell death

How tight binding between immune cells dictates T cell cancer-fighting ability

Timely transition from pediatric to adult care reduces hospitalizations for sickle cell patients

Study finds rise in hospitalizations for ischemic priapism

Comprehensive cost and utilization of commercial CAR-T therapy in pediatric B-ALL patients

Sensing a Healthier Future with Sustainable Nanomaterials and Biosensors

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Leveraging the Radian ASAP in standard casework

A journey through science, software, and innovation: Insights from the Bruker software team

CellVoyant's AI-Powered Vision for the Future of Cell Therapy

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