T Cell News and Research

Latest T Cell News and Research

Celastrol shows potential anti-SARS-CoV-2 activity

A new study published on the bioRxiv* preprint server focuses on the in-silico predictions to repurpose existing drug compounds, that may have the ability to reverse the SARS-CoV-2 gene expression induced in host cells.

23 Apr 2021

Artificial intelligence helps identify new key-lock pairs against coronavirus

The human immune defense is based on the ability of white blood cells to accurately identify disease-causing pathogens and to initiate a defense reaction against them.

23 Apr 2021

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

A team of scientists from the United States has recently compared the immune response elicited by natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Their findings reveal that, unlike vaccination, natural SARS-CoV-2 infection is associated with a robust interferon response together with an induction of cytotoxic gene expression in peripheral blood lymphocytes. The study is currently available on the medRxiv* preprint server.

22 Apr 2021

Researchers discover molecule that provides dual protection against vascular inflammation

A multidisciplinary team of researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research (A*STAR) in Singapore discovered a new mitochondrial peptide called MOCCI that plays an important role in regulating inflammation of blood vessel and immunity.

22 Apr 2021

Changing the treatment paradigm for ‘cold’ tumors

Not all cancerous tumors are created equal. Some tumors, known as "hot" tumors, show signs of inflammation, which means they are infiltrated with T cells working to fight the cancer. Those tumors are easier to treat, as immunotherapy drugs can then amp up the immune response.

22 Apr 2021

Interleukin 11-producing fibroblasts can be potential therapeutic targets for treating colorectal cancer

IL-11 is known to promote the development of colorectal cancer in humans and mice, but when and where IL-11 is expressed during cancer development is unknown.

22 Apr 2021

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice.

22 Apr 2021

New miniaturized model of neuromuscular junction formation provides insight into ALS

Skeletal muscles enable voluntary movements and are controlled by a special type of neurons called motor neurons, which make direct contact with skeletal muscles through so-called neuromuscular junctions (NMJs).

22 Apr 2021

Developing nanoparticles to detect and kill multi-resistant pathogens

Multi-resistant pathogens are a serious and increasing problem in today's medicine. Where antibiotics are ineffective, these bacteria can cause life-threatening infections.

22 Apr 2021

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

Today, the U.S. Food and Drug Administration granted accelerated approval to Jemperli (dostarlimab) for treating patients with recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing chemotherapy and whose cancers have a specific genetic feature known as dMMR (which contain abnormalities that affect the proper repair of DNA inside the cell), as determined by an FDA-approved test.

22 Apr 2021

Can SARS-CoV-2 host factor protein interactions help identify antiviral drug targets?

In a new study proteomic peptide-phage display is utilized to profile the novel SLiM-based interactions that mediate host factor interactions in 229 RNA viruses, with a special focus on SARS-CoV-2, to reveal mechanistic insights and identify drug targets.

22 Apr 2021

Pre-Clinical Vaccine Adjuvant and Therapeutics Manufacturing

Analytik reports how its Microfluidizer® processors are enabling researchers develop a range of therapeutic formulations including vaccine adjuvants, liposomes and lipid nanoparticles.

From Analytik Ltd 22 Apr 2021

California and Texas took different routes to vaccination. Who’s ahead?

California and Texas, the country's two most populous states, have taken radically different approaches to the pandemic and the vaccination campaign to end it.

22 Apr 2021

3D-printed anatomical finger model offers procedural guidance of trigger finger injections

Treatment of an injured or diseased joint may require precise insertion of a syringe needle -- musculoskeletal sonography can help guide clinicians as they drain fluid from arthritic knees or inject corticosteroids into trigger fingers.

22 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

Metabolic testing of COVID-19 patients through skin imprints

There is, therefore, a great need to understand how the illness can be diagnosed using more convenient and inexpensive methods. A new study posted to the medRxiv preprint server reveals the potential role of skin imprints to test for biomarkers that indicate a diagnosis of COVID-19 in a non-invasive way.

22 Apr 2021

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

The SARS-CoV-2 B.1.1.7 variant, also called the UK variant, was identified in London as well as in Southeast and East of England in December 2020. Since its emergence, the UK variant has undergone several mutations that have been said to have altered its infectivity and transmissibility in the community. The B.1.1.7 variant is defined by 17 mutations, several of which are located in the SARS-CoV-2 spike protein that mediates viral attachment and entry into human cells.

21 Apr 2021

Stem cell therapy can repair brain damage and improve memory function in mice

A one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia, a new UCLA study finds.

21 Apr 2021

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Researchers in the United States have developed adenovirus vectors that may be more effective at generating immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those used in the vaccines that are currently being rolled out to help combat the coronavirus disease 2019 (COVID-19) pandemic.

21 Apr 2021

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Much of common pharmaceutical development today is the product of laborious cycles of tweaking and optimization.

21 Apr 2021

T Cell News and Research

Latest T Cell News and Research

Celastrol shows potential anti-SARS-CoV-2 activity

Artificial intelligence helps identify new key-lock pairs against coronavirus

Striking difference identified between mRNA vaccination vs. SARS-CoV-2 infection immune responses

Researchers discover molecule that provides dual protection against vascular inflammation

Changing the treatment paradigm for ‘cold’ tumors

Interleukin 11-producing fibroblasts can be potential therapeutic targets for treating colorectal cancer

Experimental drug reverses key symptoms of Alzheimer's disease in mice

New miniaturized model of neuromuscular junction formation provides insight into ALS

Developing nanoparticles to detect and kill multi-resistant pathogens

FDA approves immunotherapy for treating patients with dMMR endometrial cancer

Can SARS-CoV-2 host factor protein interactions help identify antiviral drug targets?

Pre-Clinical Vaccine Adjuvant and Therapeutics Manufacturing

California and Texas took different routes to vaccination. Who’s ahead?

3D-printed anatomical finger model offers procedural guidance of trigger finger injections

Some COX inhibitors/NSAIDs increase COVID-19 severity

Metabolic testing of COVID-19 patients through skin imprints

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

Stem cell therapy can repair brain damage and improve memory function in mice

SARS-CoV-2 vaccine with single-cycle adenovirus vector

Collaborative research could expedite or eliminate the need to manually adjust bioproduction process

Immunology eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

T Cell News and Research

Latest T Cell News and Research

Immunology eBook

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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