Biopsy for Inflammatory Conditions

There are several non-cancerous conditions that may require a biopsy. Some of the other indications for biopsy can be outlined as:

Inflammatory bowel diseases

Biopsy of the gastrointestinal tract to detect suspected inflammatory bowel diseases like Crohn’s disease and Ulcerative colitis. Regular biopsies are taken to assess the activity of disease and to assess changes that appear before the lesions turn cancerous.

Renal function

Renal or kidney biopsy is indicated in alterations of renal function. Biopsy of kidney is combined with fluorescence microscopy. This helps in diagnosis of several forms of glomerulonephritis. Other indications include:

  • IgA nephropathy
  • Membranous glomerulonephritis
  • Lupus nephritis
  • Focal segmental glomerulonephritis
  • membranoproliferative glomerulonephritis
  • Interstitial nephritis
  • Rapidly progressive glomerulonephritis
  • Crescentic Glomerulonephritis  etc.

Benign breast diseases

There are several benign breast conditions that require biopsy. Some of these include:

Fibrosis and simple cysts

Fibrosis are scar-like tissue formation in breast while cysts are fluid-filled sacs. These are called fibrocystic changes. They are most often diagnosed by a doctor based on symptoms, such as breast lumps, swelling, and tenderness or pain. The symptoms worsen just before the periods. These changes are most common in women of childbearing age, but they can affect women of any age. They are the most common benign condition of the breast.


Hyperplasia or overgrowth of the cells that line the ducts or the lobules of the breast. Depending on the growths they may be ductal hyperplasia or lobular hyperplasia.

Lobular carcinoma in situ

These are abnormal cells that look like cancer cells and grow in the lobules of the milk-producing glands of the breast. This is not cancer but may progress to cancer.

Fibroadenoma and adenosis

In adenosis, the breast lobules are enlarged, and they contain more glands than usual. This is not cancerous. Sclerosing adenosis is a special type of adenosis in which the enlarged lobules are distorted by scar-like fibrous tissue.

Fibroadenomas are benign tumors made up of both glandular breast tissue and connective tissue. They are most common in young women in their 20s and 30s.

Other benign breast conditions

Other benign breast conditions that are diagnosed on biopsy include Phyllodes tumors, Intraductal papillomas, Fat necrosis and oil cysts, infections and inflammation of the breast or mastitis, radial scars, lipomas, hamartomas, hemangiomas, hematomas, adenomyoeptheliomas, and neurofibromas. None of these conditions raises breast cancer risk.

Infectious diseases

Infectious diseases are also diagnosed with biopsy. Lymph node biopsy is commonly performed to diagnose infectious diseases

Metabolic disorders

Certain metabolic disorders like Amyloidosis where degraded proteins accumulate in body tissues can be diagnosed using a biopsy.

Transplanted organs

Biopsies of transplanted organs are performed to check for graft rejection and also to see if the disease that necessitated transplant has not recurred.


In cases of infertility that is not diagnosed by other methods, a testicular biopsy is used. This is needed when the sperm quality is low, but hormone levels still are within normal ranges.


Biopsy of the temporal arteries to detect vasculitis

Further Reading

Last Updated: Jun 17, 2023

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2023, June 17). Biopsy for Inflammatory Conditions. News-Medical. Retrieved on June 17, 2024 from

  • MLA

    Mandal, Ananya. "Biopsy for Inflammatory Conditions". News-Medical. 17 June 2024. <>.

  • Chicago

    Mandal, Ananya. "Biopsy for Inflammatory Conditions". News-Medical. (accessed June 17, 2024).

  • Harvard

    Mandal, Ananya. 2023. Biopsy for Inflammatory Conditions. News-Medical, viewed 17 June 2024,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Novel blood test shows promise in detecting early-stage cancers with high accuracy