Congenital Anomalies of the Uterus

Congenital anomalies of the uterus are defects of uterine development and shape that occur during intrauterine life. Their prevalence is estimated to be less than 5%, but up to a quarter of women who have had miscarriages or preterm deliveries have such defects.

Credit: sciencepics/ Shutterstock.com

Development of the uterus

The female organs develop from the Mullerian ducts, which are a pair of organs found early in intrauterine life. Each gives rise to half of the uterus and one fallopian tube, which later fuse together to form one organ with paired fallopian tubes. Interruption of this normal course of events leads to abnormal uterine development and defects in the mature uterus.

Types

Defects of uterine development may include:

  • Septate uterus: here the uterus looks completely normal on the outside but is separated on the inside into two different halves, by a septum of varying size and thickness. Thus there are two endometrial cavities. It is by far the most common of diagnosed anomalies, making up 45% of cases.
  • Bicornuate: in this type, the uterus has an external indentation or groove marking its division internally into two endometrial cavities. The two halves of the uterus may appear almost completely separated except at the lower part. It makes up about 25% of such anomalies.
  • Arcuate uterus: here, the uterus looks normal but the internal surface of the single endometrial cavity shows a shallow groove of 1 cm or less – 7% of such anomalies
  • Unicornuate: here only half of the uterus develops, from a single Mullerian duct (15%)
  • Uterus didelphys: this is a type of anomaly in which the two halves of the uterus develop completely separate (7.5%)
  • Uterine agenesis: the uterus fails to form at all in about 10% of women with uterine anomalies

Among these, the septate and bicornuate uterine anomalies are the most common. The arcuate uterus does not have a significant clinical impact and is considered to be a variant of normal.

Causes

Most uterine anomalies occur due to unknown reasons. In more than 90% of cases, the karyotype or chromosome pattern is normal. Historically, the use of diethylstilbestrol (DES), an estrogen analogue, was prescribed to many women in the decades between 1940 and 1971, as a preventive measure for miscarriage and preterm delivery.

However, it was found to lead to a generation of women who were at increased risk for uterine anomalies, due to their exposure to DES, while still in the womb. Other than this, however, no established risk factors have been identified so far, nor any preventive measures.

Clinical features

Most women with uterine anomalies are not aware of any defect as their female physiology is typically unaffected. In most cases, fertility is unimpaired. In a few cases, dysmenorrhea or painful periods may be a symptom, though this is very nonspecific.

In infertile women, these anomalies are picked up during the routine workup. In some women renal defects are also present, with renal agenesis (absence of one kidney) being the most common associated anomaly, followed by crossed fused renal ectopia and duplex kidney.

Diagnosis and treatment

While a history of repeated miscarriage or infertility may cause a suspicion of congenital uterine anomalies, they are confirmed only by imaging studies, such as a hysterosalpingogram or scanning with ultrasound or MRI. 3D coronal transvaginal imaging is the most accurate means of ultrasound diagnosis, when performed in the secretory or second half of the monthly cycle. MRI may be preferred as non-invasive and accurate.

Surgical repair or reconstruction is the only form of treatment for such women, provided the defect is severe enough to cause obstruction of the reproductive tract, associated in many cases with infertility or miscarriages.

Septate uteri are most commonly repaired to improve the chances of having a baby, but the other types are generally left alone. In some cases, when obstruction of the female genital tract is present, surgical correction may result in permanent infertility, and so the woman should be told what to expect beforehand.

Further Reading

Last Updated: May 23, 2019

Dr. Liji Thomas

Written by

Dr. Liji Thomas

Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Thomas, Liji. (2019, May 23). Congenital Anomalies of the Uterus. News-Medical. Retrieved on September 18, 2019 from https://www.news-medical.net/health/Congenital-anomalies-of-the-uterus.aspx.

  • MLA

    Thomas, Liji. "Congenital Anomalies of the Uterus". News-Medical. 18 September 2019. <https://www.news-medical.net/health/Congenital-anomalies-of-the-uterus.aspx>.

  • Chicago

    Thomas, Liji. "Congenital Anomalies of the Uterus". News-Medical. https://www.news-medical.net/health/Congenital-anomalies-of-the-uterus.aspx. (accessed September 18, 2019).

  • Harvard

    Thomas, Liji. 2019. Congenital Anomalies of the Uterus. News-Medical, viewed 18 September 2019, https://www.news-medical.net/health/Congenital-anomalies-of-the-uterus.aspx.

Comments

  1. DES Daughter DES Daughter United Kingdom says:

    On top of what you said:
    - DES exposure also had detrimental effects on males (sons) in regards to higher cancer risk, decrease fertility, gender identity, psychological health, and more.
    - Regarding females (daughters), DES did more damage than "uterine anomalies"... the list of side effects in endless and include auto-immunity deficiency, bones issues, cardiac, etc. etc.
    - Important to realise DES also affects today's generations (3rd generation of victims). Sometimes less (DES grandaughters risk for breast cancer seems to be much lower than compared to DES daughters), sometimes more (DES grandsons risk for hyspospadias is doubled - 8% - compared to DES sons).
    - Oh, and DES was never effective for what it was marketed as such ; it did not prevent miscarriage. Actually it was the opposite, some studies showed DES increased the risk for early deliveries, preterm birth. Guess what : it became used as an abortion pill... and is still used for that purpose in some remote countries... Looks like pharma will not miss any opportunity to sell their products...

    Many thanks for mentioning DES in your article. It is important for doctors and the general public to realise DES is not a tragedy of the past, but still affecting young people today.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Childbirth delivery mode linked with woman’s risk of developing pelvic floor disorders