This article and associated images are based on a poster originally authored by Dr. Jessica Watts, Dr. Nellie Chourmouziadi Laleni, Dr. Agatha Rosenthal and Dr. John Stenson and presented at ELRIG Drug Discovery 2026 in affiliation with Malvern Panalytical Ltd.
This poster is being hosted on this website in its raw form, without modifications. It has not undergone peer review but has been reviewed to meet AZoNetwork's editorial quality standards. The information contained is for informational purposes only and should not be considered validated by independent peer assessment.
Monoclonal antibodies (mAbs) are an important class of biotherapeutics whose efficacy and safety depend on maintaining stability throughout development, manufacturing, and storage. Formulation conditions, including buffer composition, salt concentration, and excipients, can significantly influence protein stability and aggregation behavior. Rapid, low-volume screening enables fast identification of stable formulations while minimizing sample consumption and experimental time.
The Zetasizer Core
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
- Plate-based system
- 96-, 384-, 1539-microwell plates
- High throughput
- 96 or 192 samples at 1 °C per minute
- DLS, SLS, and DSF independent detectors
- Five-click method setup
- Thermal lag-immune data
- Gold standard algorithms
Which buffer best maintains colloidal stability?
Colloidal stability: DLS analysis
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
Thermal stability: DSF/SLS analysis
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
Which salt conditions give the best stability profiles?
Colloidal stability: Direct B22 measure
Effect of salt concentration on B22
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
- B22 analysis revealed higher stability at lower salt concentrations due to reduced interparticle interactions.
Thermal stability: DSF/SLS analysis
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
- Increasing NaAc concentrations caused a decrease in thermal stability
From formulation screening to stability insight in less than 1.5 hours
Methodology:
Rapid, low volume screening:
Image Credit: Image courtesy of Dr. Jessica Watts et al., in partnership with ELRIG (UK) Ltd.
- Atezolizumab in eight formulations, eight replicates each
- DLS → colloidal stability
DSF/SLS → thermal stability
B22 → interaction potential
Conclusion
Screen faster and identify stable formulations earlier. The Zetasizer Core enables high-throughput DLS, SLS, and DSF to rapidly characterize antibody formulation stability in <1.5 hours, accelerating workflows in formulation development and screening.
About Malvern Panalytical
Malvern Panalytical, together with Micromeritics Instrument Corporation and SciAps, represents a powerful and highly complementary combination of market-leading technologies. We bring together decades of scientific expertise to deliver advanced analytical solutions that measure the chemical, physical, and structural properties of materials - from proteins and polymers to batteries, catalysts, semiconductors, and minerals.
- Malvern Panalytical specializes in particle characterization, X-ray diffraction (XRD), X-ray fluorescence (XRF), and molecular interaction analysis.
- Micromeritics is a global leader in surface area and porosity analysis, particle characterization, and density measurement solutions.
- SciAps delivers portable, high-performance XRF and Raman analyzers for field-based elemental and materials analysis.
With more than 92,000 systems installed worldwide and operations across North America, Europe, and Asia, our technologies help customers accelerate innovation, optimize processes, and ensure quality across industries including pharmaceuticals, advanced materials, energy storage, chemicals, metals, mining, and environmental science.
As part of Spectris plc, we are committed to sustainability, customer support excellence, and enabling a cleaner, healthier, and more productive world.
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Last Updated: Oct 12, 2026
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