Semen Allergy

NewsGuard 100/100 Score

Some people, both men and women are known to be allergic to the proteins present in semen. This is termed human seminal plasma hypersensitivity. 

Allergy to a certain enzyme, protein or chemical means the person’s immune system overreacts each time it encounters that protein or chemical.

The symptoms of an allergy may be localized where the chemical or protein has come in contact with the body or may be more widespread or systemic. Systemic allergy means there may be a generalized whole body reaction on exposure to the chemical.

Localized semen allergy

In individuals with localized allergy to semen, there is vaginal itching in the allergic woman or itching in the penis is the man is allergic to his own semen. The vagina or penis (as the case may be) is itchy, red, swollen and develops blisters within 30 minutes of coming in contact with the semen after ejaculation.

Generalized semen allergy

Allergy may also be more generalized. This leads to itching all over the body as well as hives.

Some patients may develop flu like illness after an orgasm called post-orgasmic illness syndrome or POIS. Symptoms include fever, runny nose, fatigue and burning eyes, which can last for up to a week.

Severe allergies have been reported in some isolated reports. This includes life threatening anaphylaxis reactions. This type of severe hypersensitivity is commonly seen with allergens like peanut butter or penicillin allergies. The affected person develops shortness of breath, swelling of the voice box or larynx and throat choking the airways along with severe fall in blood pressure. Immediate emergency management is required to save the patient.

Testing for semen allergy

The most common testing method is to use a condom during intercourse. If symptoms are not seen with condom use semen allergy is suspected in the woman. For men with semen allergy, traditional allergy tests including skin prick allergy tests are recommended.

Management of semen allergy

Mild cases do not require treatment and usually go away on repeated exposure. In severe cases help of the physician needs to be sought. This is more so if the couple is trying to conceive.

Semen allergy is a cause of infertility in a couple and may also lead to miscarriages and early loss of pregnancies. In these cases artificial reproductive technologies that include sperm washing and artificial insemination may be used.

Last Updated: Jun 13, 2023

Dr. Ananya Mandal

Written by

Dr. Ananya Mandal

Dr. Ananya Mandal is a doctor by profession, lecturer by vocation and a medical writer by passion. She specialized in Clinical Pharmacology after her bachelor's (MBBS). For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Mandal, Ananya. (2023, June 13). Semen Allergy. News-Medical. Retrieved on June 13, 2024 from

  • MLA

    Mandal, Ananya. "Semen Allergy". News-Medical. 13 June 2024. <>.

  • Chicago

    Mandal, Ananya. "Semen Allergy". News-Medical. (accessed June 13, 2024).

  • Harvard

    Mandal, Ananya. 2023. Semen Allergy. News-Medical, viewed 13 June 2024,


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Navigating the influencer landscape: The positive and negative effects of social media influencers on adolescents