Submacular Hemorrhage (SMH)

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Submacular hemorrhage (SMH) is a term which describes a condition characterized by the presence of blood in the potential space between the retinal pigment epithelium and the retinal layer. The blood comes from fragile new vessels in the choroidal layer, formed in the process of choroidal neovascularization CNV). The patient with SMH suffers acute and painless visual distortion with eventual loss of central vision.

In the majority of patients, CNV is due to age-related macular degeneration. Other causes include:

  • High myopia
  • Scars following inflammatory conditions
  • Trauma to the eye
  • Angioid streaks
  • Histoplasmosis of the eye
  • Choroidal vascular conditions of unknown origin
Subretinal tPA in case with massive subretinal hemorrhage


Submacular hemorrhage is a sight-threatening disorder. When it occurs, the patient may report that there is a sudden blurring of vision, as well as waviness of lines. This phenomenon is called metamorphopsia, and occurs in the center of the visual field, or, in other words, with respect to the object one is directly looking at.


Following a hemorrhage into the submacular space, the outer layers of the retina deteriorate and break down speedily. This is because of:

  • Disruption of the connections between the RPE and the photoreceptor cells inhibiting normal diffusion between them, culminating in rapid photoreceptor atrophy
  • Contraction of the organizing clot leading to shear stress on the attached retina and the formation of retinal scars
  • The toxic effects of the iron released from the red cells breaking down in the clot
  • Other toxins released from stressed tissue
  • Migration of cells into the subretinal space with subsequent proliferation
  • Formation of a proliferative fibrovascular membranous layer over the retina


A submacular hemorrhage is an emergency to be treated by removal of the clot on an urgent basis. The techniques in common use include:

  • Manual clot removal following vitrectomy
  • Vitrectomy with recombinant tissue plasminogen activator (r-tPA) injection into the intravitrealspace to dissolve the clot, and placement of intraocular gas to displace the clot
  • Removal of the membrane formed by the new vessels, done alone or as part of the above procedure
  • Instillation of gas to displace the clot, without r-tPA injection
  • Injection of r-tPA subretinally along with the instillation of perfluorocarbon liquid to displace the SMH into the vitreous space for manual removal
  • Adjuvant therapy with anti-VEGF (vascular endothelium growth factor) injection to discourage neovascularization and subsequent bleeds, and maintain the improvement due to clot displacement
  • Focal photocoagulation by laser is used to seal the bleeding submacular vessels


The prognosis of a submacular hemorrhage depends upon the size and extent. A large SMH is often the cause of irreversible vision loss, with or without treatment. If the SMH is an extension of a subretinal hemorrhage, it is often treatable, but complete recovery of normal vision is difficult to achieve. When, as is very often the case, the SMH is a complication of the exudative (“wet”) form of AMD, half of these patients will develop another SMH in less than 3 years from the onset of the first.


Further Reading

Last Updated: Dec 29, 2022

Dr. Liji Thomas

Written by

Dr. Liji Thomas

Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.


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