What is Cardioprotection?

NewsGuard 100/100 Score

What is ischemic reperfusion injury (IRI) and its causes?
Cardioprotective agents and strategies
Future directions
Further reading

Cardioprotection refers to any intervention which seeks to decrease the risk of developing any adverse cardiovascular event; namely preserving the function of the heart by reducing or preventing damage, such as myocardial infarction and other sequelae of ischemia or reperfusion.

Image Credit: Elle Aon/ShutterstockImage Credit: Elle Aon/Shutterstock

Cardioprotection is an umbrella term that includes several strategies that have been shown to preserve the function and viability of cardiac muscle cell tissue subjected to ischemic insult or reoxygenation. These strategies may be implemented at three possible time points; before an ischemic event (preconditioning), during an ischemic event (preconditioning), after an ischemic event, and during reperfusion (postconditioning).

Further stratification of cardioprotection can occur by performing the intervention either locally or remotely. This gives rise to classes of conditioning called remote ischemic preconditioning (RIPC), remote ischemic postconditioning, and remote ischemic postconditioning.

What is ischemic reperfusion injury (IRI) and its causes?

Ischemic heart disease is considered to be the leading cause of death and disability across the world. The consequences of ischemic heart disease result from the subsequent effects of acute ischemic reperfusion injury (IRI), which causes the death of cardiomyocytes, cardiac failure, the development of arrhythmias, and patient death. This is paradoxical, as restoring blood flow to previously ischemic tissue (essential to salvage what is left) results in later damage to the heart. this is the main target for cardioprotective strategies.

The clinical settings in which the heart is subject to acute IRI include:

  1. The acute ST-segment elevation myocardial infarction (STEMI): a patient with acute myocardial ischemia due to coronary artery occlusion at the site of a ruptured atherosclerotic plaque is reperfused by the primary percutaneous coronary intervention (PPCI) to restore coronary blood flow. There is currently no effective therapy for preventing myocardial reperfusion injury, which is a form of cardiomyocyte death following reperfusion of the ischemic myocardium
  2. Ischemic heart disease patient undergoing coronary artery bypass graft (CABG)
  3. Heart transplantation – here, the heart is subject to widespread, actual IRI despite attempts at cardioprotection

In each of these chemicals setting examples to come up with patient mobility and mortality is still challenging. Several therapeutic interventions have been investigated to combat IRIs but have been largely unsuccessful. As such, new treatment strategies which target novel pathways for cardioprotection are needed to limit myocardial infarct size and ensure the preservation of cardiac function. This thereby prevents the onset of heart failure and increases the likelihood of patient survival.

Related: Just 30 minutes of exercise each day can lower heart disease risk

Cardioprotective agents and strategies

Despite the use of several strategies to prevent injury to the heart and limit myocardial infarct size, these strategies continued to fail. First attempts at cardioprotection were acquired over 40 years ago, and despite the belief that therapeutic intervention can limit the size of the myocardial infarct, evidence to prove that this can occur is yet to be seen, with a noticeable exception being early coronary artery profusion.

The potential cardioprotective agents that have been tested in clinical trials to reduce myocardial infarct size or improve ventricular function last have shown promise, include:

  • Use of adenosine
  • Therapeutic hypothermia
  • Hypoxemic reperfusion: No overall difference seen - the patients with anterior acute myocardial infarction reperfused in less than six hours
  • Use of glucose, insulin, and potassium
  • Ischemic postconditioning
  • Cyclosporine A
  • Atrial natriuretic peptide (ANP)
  • Protein kinase Cδ Inhibitor

Future directions

The most urgent direction that needs to be taken concerning cardioprotection is its transferability in humans. To be studied in patients, preclinical evidence must be obtained. Most notably, lack of reproducibility has confounded the field of cardioprotection. As approximately 1,000,000 Americans suffer acute my cordial infarction every year, and the prognosis depends on the amount of damage sustained by the heart, reducing infarct size is hoped to diminish the prevalence of heart failure and reduce mortality.

Image credit: Shot4Sell/Shutterstock


Further Reading

Last Updated: Dec 30, 2022

Hidaya Aliouche

Written by

Hidaya Aliouche

Hidaya is a science communications enthusiast who has recently graduated and is embarking on a career in the science and medical copywriting. She has a B.Sc. in Biochemistry from The University of Manchester. She is passionate about writing and is particularly interested in microbiology, immunology, and biochemistry.


Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Aliouche, Hidaya. (2022, December 30). What is Cardioprotection?. News-Medical. Retrieved on April 20, 2024 from https://www.news-medical.net/health/What-is-Cardioprotection.aspx.

  • MLA

    Aliouche, Hidaya. "What is Cardioprotection?". News-Medical. 20 April 2024. <https://www.news-medical.net/health/What-is-Cardioprotection.aspx>.

  • Chicago

    Aliouche, Hidaya. "What is Cardioprotection?". News-Medical. https://www.news-medical.net/health/What-is-Cardioprotection.aspx. (accessed April 20, 2024).

  • Harvard

    Aliouche, Hidaya. 2022. What is Cardioprotection?. News-Medical, viewed 20 April 2024, https://www.news-medical.net/health/What-is-Cardioprotection.aspx.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Boosting heart health with rewards and fun: How incentives and games encourage exercise