Life Science Articles

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Holotomography in Cell Biology

Holotomography is a scientific method used to image cells in two- and three-dimensions without the need for sectioning or labeling with external proteins.

24 Oct 2018

Minimizing Photobleaching in Fluorescence Microscopy

Photobleaching is a process whereby fluorophores lose their vibrancy, causing the signal to fade. Read our step-by-step guide to reducing photobleaching.

24 Oct 2018

Mannan-binding Lectin Serine Protease (MASP) Family

The Mannan-binding lectin serine protease (MASP) protein family is critical for the complement pathway in the immune system.

24 Oct 2018

What are PARP inhibitors?

PARP inhibitors are pharmaceutical drugs that can be used to treat many different forms of cancer, including ovarian and breast cancer.

24 Oct 2018

Cell Preparation for Flow Cytometry

This article describes how to prepare cells for flow cytometry, a popular technique used to analyze cell size, volume, and molecule expression.

23 Oct 2018

Cell Cycle Analysis Using Flow Cytometry

This article describes how to analyze the cell cycle using flow cytometry, with examples from scientific studies.

23 Oct 2018

Ion Channel Electrophysiology

Ion channels are imperative to the normal functioning of the cell. The study of ion channels is called electrophysiology, and is described in this article.

23 Oct 2018

Patch Clamp Configurations

The patch clamp technique is used to study ion channel electrophysiology across the cell membrane. There are several configurations, each with pros and cons.

23 Oct 2018

Automated Patch Clamp Techniques

This article describes the applications of automated patch clamp techniques and the benefits of each.

23 Oct 2018

How to Calibrate a pH Meter

A pH meter measures a pH or the acidity/alkalinity of substances. Usually, pH meters need to be calibrated every day or week.

22 Oct 2018

Bacterial Stress Responses

This article describes bacterial stress responses, which boost the survival of bacterium in extreme environmental conditions.

22 Oct 2018

Antibody Purification Techniques

This article describes the techniques used in the purification of monoclonal and polyclonal antibodies from a serum sample.

22 Oct 2018

Pyrosequencing in DNA Methylation Analysis

This article explains pyrosequencing - a sequencing-by-synthesis method which can be applied to measure DNA methylation at CG sites.

18 Oct 2018

Tyramide Signal Amplification (TSA) Applications

Tyramide signal amplification (TSA) is a biological technique used to detect proteins, DNA, and viruses. It can be combined with other techniques such as FISH.

18 Oct 2018

Antimicrobial Properties of Nanoparticles

Nanoparticles are potential broad-spectrum antibiotic agents, and they can overcome evolved resistances to conventional antibiotics. The over-use of regular antibiotics has created ‘superbugs’, bacteria that are resistant to almost all types of antibiotics. Nanoparticles may present a promising solution to this public health hazard.

17 Oct 2018

Silica Nanoparticle Applications in Biomedicine

Silica nanoparticles of between 1 – 100 nm in diameter are cost-effective and simple to produce, with a highly modifiable surface chemistry, shape, and size. They commonly act as a support scaffold or coating for biomolecules or other nanoparticles and potentially make excellent drug delivery platforms due to their highly biocompatible nature and porous structure.

17 Oct 2018