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Researchers develop strategies to identify regulators of intestinal hormone secretion

A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion.

18 Oct 2024

Scientists map the genetic landscape of drug resistance in cancers

All cancer mutations that cause drug resistance fall into one of four categories. New research has detailed each type, helping to uncover targets for drug development and identify potential effective second-line therapies.

18 Oct 2024

New glucose-sensitive insulin NNC2215 could transform diabetes care by lowering hypoglycemia risk

NNC2215, a glucose-sensitive insulin, offers improved glycemic control by dynamically adjusting to blood sugar levels, reducing hypoglycemia in diabetes care.

18 Oct 2024

Ubiquigent partners with Alleo Labs to advance DUB-targeting therapies

Ubiquigent Limited (“Ubiquigent”), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced a strategic partnership with Alleo Labs Corp. (“Alleo”), a pioneer in using artificial intelligence (AI) to develop new therapeutics for neurological diseases.

18 Oct 2024

Researchers create first single cell atlas of prenatal human skin

For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.

18 Oct 2024

New research highlights genetics as key factor in BMI and obesity risk

Genomics’ latest groundbreaking research, showcased at the Bupa Health Symposium, shows that a person’s genetic background is a key driver for their BMI and therefore is crucial to understanding their risk of obesity.

18 Oct 2024

Sapio Sciences enhances lab informatics platform with new immunogenicity bioanalysis features

Sapio Sciences, the science-aware™ lab informatics platform, today announced the addition of new immunogenicity bioanalysis features to its industry-leading lab informatics platform.

18 Oct 2024

New protein found to protect cells from age-related decline

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

18 Oct 2024

Study identifies genetic associations with youth psychopathology

When trying to understand how genetic influences factor into youth behavior, researchers at Washington University in St. Louis have taken the "big trawl" approach, casting their net wide to pull in all the measured traits, behaviors and environments that make up who we are and examine associations with the genetic building blocks comprising risk for mental health problems.

17 Oct 2024

Brazil-Italy joint lab focuses on Alzheimer’s drug development

A self-proclaimed Brazil-Italy collaboration enthusiast, researcher Laura Bolognesi created the B2AlzD2 Joint Lab at the Department of Pharmacy and Biotechnology of the Università di Bologna (UNIBO), the first Brazil-Bologna joint laboratory dedicated to the development of new drugs for the treatment of Alzheimer's disease.

17 Oct 2024

New synthesis technology promises faster production of mRNA vaccines

In an era where viral outbreaks can escalate into global pandemics with alarming speed, the ability to quickly develop new vaccines has become crucial.

17 Oct 2024

Discovering new natural products from human microbiomes

The idea of using microorganisms as a source of new active ingredients is not new. Numerous drugs have already been developed on the basis of natural products from bacteria and fungi.

17 Oct 2024

New genetic variant may predict severe ulcerative colitis in patients

Abdominal pain, diarrhea, and debilitating fatigue define the daily lives of millions of people worldwide who suffer from chronic bowel disease.

17 Oct 2024

Adenine base editors show potential to correct X-CGD-causing mutations

A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.

16 Oct 2024

Molecular chaperones as key players in tumor suppressor stability

A new review was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Molecular chaperones: Guardians of tumor suppressor stability and function."

16 Oct 2024

Enhancing mRNA lifespan: A step forward in therapeutic development

mRNA-based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA.

16 Oct 2024

Male mice use female distraction to deescalate aggression, study finds

A research group led by Joshua Neunuebel at the University of Delaware, USA, tracked the behavior of mice using machine learning to understand how they handle aggressive behavior from other mice.

16 Oct 2024

Study reveals genetic factors affecting birth sex ratios

Each year, roughly the same numbers of boys and girls are born.

16 Oct 2024

Two programs found to control invasion and inflammation in segregated tumor cell populations

Understanding in depth how tumors evolve to become malignant is the objective of the latest study led by the Cell Plasticity in Development and Disease laboratory, directed by ángela Nieto at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.

16 Oct 2024