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Machine learning identifies drugs that could be repurposed to help people quit smoking cigarettes

Medications like dextromethorphan, used to treat coughs caused by cold and flu, could potentially be repurposed to help people quit smoking cigarettes, according to a study by Penn State College of Medicine and University of Minnesota researchers.

30 Jan 2023

$1 million grant will help University of Utah chemists to speed up the drug development process

Michael Grünwald, Ryan Looper and Rodrigo Noriega, of the University of Utah Department of Chemistry, received a $1 million grant from the W.M. Keck Foundation funding studies of currently unpredictable aspects of the process of crystallization.

30 Jan 2023

Novel class of sulfonamides to block malaria transmission

Malaria is a devastating disease, with 247 million cases and 619,000 deaths reported in 2021 alone. Malaria causes fever and a flu-like illness that occurs when people are infected with the parasite Plasmodium falciparum, which is spread by mosquitoes.

30 Jan 2023

Novel mathematical model simulates how an average person's body regulates potassium

Having levels of potassium that are too high or too low can be fatal. A new mathematical model sheds light on the often mysterious ways the body regulates this important electrolyte.

30 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

The vital role of oxytocin - the "love hormone" - for social attachments is being called into question. More than forty years of pharmacological and behavioral research has pointed to oxytocin receptor signaling as an essential pathway for the development of social behaviors in prairie voles, humans, and other species, but a genetic study publishing in the journal Neuron on January 27 shows that voles can form enduring attachments with mates and provide parental care without oxytocin receptor signaling.

29 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Activated neutrophils can become potent cancer fighters

Elevated levels of immune cells, called neutrophils, in tumors have been associated with poor outcomes in people with cancer.

27 Jan 2023

Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

27 Jan 2023

Survey: Trust in genetics increased significantly during the pandemic

A survey of over 2,000 British adults finds that trust in genetics is high and went up significantly during the pandemic. It also finds that there is a hunger for more coverage of genetics.

27 Jan 2023

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

Microtubules are cellular fibres that are part of the skeleton of the cell, termed cytoskeleton. They ensure that cells maintain their shape, carry out their functions, and divide.

27 Jan 2023

AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

26 Jan 2023

Study shows mechanical tearing as a novel mechanism during neurite pruning

Nerve cells communicate with one another via long processes known as axons and dendrites, or, more generally, neurites.

26 Jan 2023

bit.bio partners with Automata to automate a key aspect of its production of iPSC derived human cells

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From Automata 26 Jan 2023

Researchers discover new transporter used by some bacteria to recycle cell wall fragments

A transporter which some bacteria use to recycle fragments of their cell wall has been discovered by researchers at Umeå university, Sweden.

26 Jan 2023

New spray can have a dual impact in the fight against antibiotic resistance

The World Health Organization ranks antibiotic resistance as one of the top ten threats to global health. There is therefore a great need for new solutions to tackle resistant bacteria and reduce the use of antibiotics.

26 Jan 2023

Special vascular cells sense when the brain region needs energy

When we smell hot dogs, it may trigger memories of backyard barbeques or attending baseball games during childhood.

26 Jan 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy - weakness, numbness, and pain, primarily in the hands and feet.

25 Jan 2023

Life Science News

Machine learning identifies drugs that could be repurposed to help people quit smoking cigarettes

$1 million grant will help University of Utah chemists to speed up the drug development process

Novel class of sulfonamides to block malaria transmission

Novel mathematical model simulates how an average person's body regulates potassium

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Voles can form enduring attachments with mates and provide parental care without oxytocin receptors

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Activated neutrophils can become potent cancer fighters

Researchers identify an unexpected driver of cancer immunotherapy resistance

Survey: Trust in genetics increased significantly during the pandemic

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

AI tool promises to accelerate the development of gene therapies on a large scale

Study shows mechanical tearing as a novel mechanism during neurite pruning

bit.bio partners with Automata to automate a key aspect of its production of iPSC derived human cells

Researchers discover new transporter used by some bacteria to recycle cell wall fragments

New spray can have a dual impact in the fight against antibiotic resistance

Special vascular cells sense when the brain region needs energy

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Researchers gain systematic insight into the organization of proteins in mitochondria

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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