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Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein.

3 Feb 2023

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria.

3 Feb 2023

New therapeutic vaccine based on an allogeneic Plasmacytoid DC cell line

A new research perspective was published in Genes & Cancer on January 30, 2023, entitled, "Leveraging a powerful allogeneic dendritic cell line towards neoantigen-based cancer vaccines."

3 Feb 2023

The human body develops strategies to prevent the immune response from overshooting its mark

The signaling molecules of the immune system should trigger a response only where necessary. To prevent a life-threatening spread to the rest of the body, connective tissue can absorb these molecules like a sponge.

3 Feb 2023

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Researchers discuss the role of a surfactant-mediated inflammatory response employed by human lungs against SARS-CoV-2.

3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

Partially quasi-programmed diseases can be delayed by slowing aging

A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, entitled, "Are menopause, aging and prostate cancer diseases?"

3 Feb 2023

Researchers develop a cell line to address the challenges facing cellular modeling of disease

Bill Skarnes and team established and characterized a stable iPSC line, KOLF2.1J, to act as a high-quality baseline platform for modeling human disease.

3 Feb 2023

Improving CAR-based-immunotherapies using a molecular anchor

Adding a molecular anchor to the key protein used to recognize cancer in cellular immunotherapies can make the treatments significantly more effective.

3 Feb 2023

Oncodesign Services looks to the future

As Oncodesign evolves into Oncodesign Services and begins its journey as an independent business, CEO Fabrice Viviani explains his hopes and plans for the company’s future.

From Oncodesign Services 3 Feb 2023

ERES IV acquires a majority stake in Oncodesign Services

Oncodesign Services, a leading Contract Research Organization (CRO) specializing in drug discovery and preclinical services in oncology and immuno-inflammation, and Elyan Partners announce the completion of the acquisition of a majority stake in Oncodesign Services by ERES IV, representing 61.58% of its share capital, from its main shareholders, including Mr. Philippe Genne, Founder of Oncodesign Services, as well as certain key shareholders and several managers and minority shareholders, following the entry into exclusive negotiations on June 30, 2022.

From Oncodesign Services 3 Feb 2023

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

An unexpected discovery made by experts at the Brain Tumor Center at Cincinnati Children's while studying a rare-but-deadly type of brain tumor may also lead to improved treatments for several other forms of cancer that share a common influencing factor called a YAP fusion protein.

2 Feb 2023

Research project aims to shed new light on how proteins in viruses bind to molecules

The way in which molecules interact forms the basis of life and treating illness. But what does it look like when a viral protein meets and binds to molecules like those found in medications? A new research project has been awarded DKK 65 million by the European Research Council and will now aim to shed light on this hitherto invisible process.

2 Feb 2023

Study offers clues about the biology of cells in the spinal cord that die off in ALS

New research offers clues about the biology of cells in the spinal cord that die off in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.

2 Feb 2023

UC Davis launches new institute to advance basic knowledge of psychedelics and neurotherapeutics

The University of California, Davis has launched the Institute for Psychedelics and Neurotherapeutics to advance basic knowledge about the mechanisms of psychedelics and translate it into safe and effective treatments for diseases such as depression, post-traumatic stress disorder, addiction, Alzheimer's disease and Parkinson's disease, among others.

2 Feb 2023

Life Science News

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

New therapeutic vaccine based on an allogeneic Plasmacytoid DC cell line

The human body develops strategies to prevent the immune response from overshooting its mark

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Molnupiravir-related mutational signatures among COVID-19 patients

Partially quasi-programmed diseases can be delayed by slowing aging

Researchers develop a cell line to address the challenges facing cellular modeling of disease

Improving CAR-based-immunotherapies using a molecular anchor

Oncodesign Services looks to the future

ERES IV acquires a majority stake in Oncodesign Services

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

Research project aims to shed new light on how proteins in viruses bind to molecules

Study offers clues about the biology of cells in the spinal cord that die off in ALS

UC Davis launches new institute to advance basic knowledge of psychedelics and neurotherapeutics

Novel tool uses AI to predict the efficacy of genome-editing repair options

Researchers identify a gene that drives T lymphocytes to exhaustion

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

Immunomodulatory antibodies found to be successful in treating cancer when they have a looser grip

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

Latest Life Science News