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IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

CRISPR/Cas9 is a commonly used, very precise, gene editing technique whose development, by Jennifer A. Doudna and Emmanuelle Charpentier, was recognised with the 2020 Nobel Prize in Chemistry. Commonly known as "genetic scissors", CRISPR allows the introduction of the desired DNA sequence into (virtually) any spot of the genome, thus modifying or inactivating a gene. This technique is widely used in biomedical research and some CRISPR-based therapies are in clinical trials for the treatment of human blood disorders, some types of cancer and HIV, among other conditions.

10 Aug 2022

Senate Commission’s position paper makes a timely contribution to the ongoing debate on animal experimentation

The DFG's Permanent Senate Commission on Animal Protection Experimentation has published a detailed "Position Paper on Ensuring High-Performance Biomedical Research While Maintaining the Highest Animal Welfare Standards".

10 Aug 2022

Rice University researchers model a key mechanism by which DNA replicates

Knowing the structure of a complex biological system isn't nearly enough to understand how it works. It helps to know how the system moves.

10 Aug 2022

Next-generation sequencing system yields results comparable to traditional diagnostics

In the pursuit of accurate diagnoses for illnesses, doctors have traditionally used multiple methods — including culturing patient samples on a wide variety of media, reviewing countless medical records and analyzing clinical data using complex mathematical algorithms — to try to identify the bacterium, virus, fungus or other pathogen responsible for an infection.

10 Aug 2022

A broad sarbecovirus-neutralizing antibody cocktail

Researchers present a rational approach for identifying SARS-CoV-2 receptor-binding domain-targeted broad neutralizing antibody cocktails.

9 Aug 2022

Neuronal cilia are important for dopamine receptor 1 signaling, study shows

A historically overlooked rod-like projection present on nearly every cell type in the human body may finally be getting its scientific due: A new study has found that these appendages, called cilia, on neurons in the brain have a key role in ensuring a specific dopamine receptor's signals are properly received.

9 Aug 2022

Next-generation monoclonal antibody prevents malaria

Researchers investigate the pharmacokinetics and safety of L9LS, a monoclonal antibody to prevent malaria.

9 Aug 2022

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Chemists from Scripps Research and the University of California, Los Angeles, have developed methods for the precise, flexible modification of a broad class of chemical compounds called bicyclic aza-arenes, which are commonly used to build drug molecules.

9 Aug 2022

Pathogens in ancient DNA could explain how two civilizations collapsed

The current study has strongly indicated the presence of Y. pestis and S. enterica on the island of Crete that contributed to societal changes during 2,000 BCE.

9 Aug 2022

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Around 15 years ago, a group of researchers discovered mutant zebrafish. The eyes of these zebrafish did not develop correctly, resulting in them being significantly smaller than the eyes of wild zebrafish.

9 Aug 2022

Researchers create the most bio-realistic and complex computer models of brain cells

Cedars-Sinai investigators have created the most bio-realistic and complex computer models of individual brain cells - in unparalleled quantity.

9 Aug 2022

Species across the animal kingdom show signs of cognitive impairment with disease

Is brain fog a condition limited to humans? "Infectious disease and cognition in wild populations," a recently published paper in Trends in Ecology & Evolution, answers that question. In a review of the studies, it explores whether learning, memory, and problem-solving are impaired by infection, not just in humans, but in species across the animal kingdom.

9 Aug 2022

Study estimates the environmental impact of food and drink products in a standardized way

A study estimating the environmental impact of 57,000 food products in the UK and Ireland has been published this week in the journal PNAS by an Oxford-led research team .

9 Aug 2022

Grape consumption alters gene expression in the brain and has positive effects on behavior and cognition

Recent studies released by Dr. John Pezzuto and his team from Western New England University show "astonishing" effects of grape consumption and "remarkable" impacts on health and on lifespans.

9 Aug 2022

Novel AI tools accurately predict the role of DNA’s regulatory elements

Newly developed artificial intelligence (AI) programs accurately predicted the role of DNA's regulatory elements and three-dimensional (3D) structure based solely on its raw sequence, according to two recent studies in Nature Genetics.

9 Aug 2022

Research projects the future mortality burden due to hot nights

Excessively hot nights caused by climate change are predicted to increase the mortality rate around the world by up to 60% by the end of the century, according to a new international study that features research from the UNC Gillings School of Global Public Health.

9 Aug 2022

Study reveals key similarities between the nervous system of two early-diverging animal lineages

Neurons, the specialized cells of the nervous system, are possibly the most complicated cell type ever to have evolved. In humans, these cells are capable of processing and transmitting vast sums of information. But how such complicated cells first came about remains a long-standing debate.

9 Aug 2022

Researchers unravel a novel molecular target of eicosapentaenoic acid

Eicosapentaenoic acid (EPA) is an essential nutrient belonging to the omega-3 group of polyunsaturated fatty acids (PUFAs). As the human body cannot synthesize PUFAs, dietary supplements containing EPA are required for normal physiological functions. Found abundantly in natural sources like fish, hemp oil, and linseed oil, EPA is known to exhibit anti-inflammatory, neuroprotective, and cardiovascular protective activities.

9 Aug 2022

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

In partnership with BGI Genomics from China, Serbia's first genome sequencing center, opened in December 2021, is monitoring potential virus mutations to facilitate more effective COVID-19 control and accelerating access to genomics to enhance health outcomes.

9 Aug 2022

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Personalized medicine for lung cancer using molecular-targeted drugs is common but there have been no prospective validation studies done on the usefulness of lung cancer gene panel testing using cytology samples.

8 Aug 2022

Life Science News

IRB scientists identify critical spots on the genome where gene editing could cause an unwanted response

Senate Commission’s position paper makes a timely contribution to the ongoing debate on animal experimentation

Rice University researchers model a key mechanism by which DNA replicates

Next-generation sequencing system yields results comparable to traditional diagnostics

A broad sarbecovirus-neutralizing antibody cocktail

Neuronal cilia are important for dopamine receptor 1 signaling, study shows

Next-generation monoclonal antibody prevents malaria

Scripps, UCLA chemists develop a 'molecular editing' toolkit for modifying bicyclic aza-arenes

Pathogens in ancient DNA could explain how two civilizations collapsed

The eyes of mutant zebrafish help understand the role of a protein in preventing cell death

Researchers create the most bio-realistic and complex computer models of brain cells

Species across the animal kingdom show signs of cognitive impairment with disease

Study estimates the environmental impact of food and drink products in a standardized way

Grape consumption alters gene expression in the brain and has positive effects on behavior and cognition

Novel AI tools accurately predict the role of DNA’s regulatory elements

Research projects the future mortality burden due to hot nights

Study reveals key similarities between the nervous system of two early-diverging animal lineages

Researchers unravel a novel molecular target of eicosapentaenoic acid

Serbia's genome center monitors potential virus mutations to facilitate more effective COVID-19 control

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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