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New low-cost technique helps profile dynamic metabolic features from single isogenic cells

Researchers with the Single-Cell Center, Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, have developed a fast, low-cost and high-throughput technique capable of profiling dynamic metabolic features from just one isogenic sample of cells.

1 Sep 2021

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of lung disease characterized by relentless scarring leading to death within an average of four years from the time of diagnosis.

31 Aug 2021

Researchers show how a protein molecular motor can 'constrict' cell membranes

Cells in the human body constantly receive substances from the outside via a process called endocytosis. One important endocytosis pathway involves the formation of a protrusion within the cell membrane, pointing to the inside of the cell, triggered when a molecule needing to get in reaches the membrane.

31 Aug 2021

Scientists identify small compounds that can regulate extracellular vesicle production

Biological vesicles are nano-sized containers that transport proteins and other substances within or between cells.

31 Aug 2021

Researchers decipher genetic mechanisms governing the speed of protein synthesis

In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesise the appropriate proteins.

31 Aug 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

$1.3 million in NIH funding to enable drug delivery technology research

Two National Institute of Health grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumey, assistant professor of pharmaceutical sciences at Binghamton University, State University of New York, is the Principal Investigator on both grants -; $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.

31 Aug 2021

Researchers develop adult lung organoids that represent all cell types

Since the COVID-19 pandemic reached the United States in early 2020, scientists have struggled to find laboratory models of SARS-CoV-2 infection, the respiratory virus that causes COVID-19. Animal models fell short; attempts to grow adult human lungs have historically failed because not all of the cell types survived.

31 Aug 2021

Study uses novel technology to map the brain circuitry of spirituality

Scientists have long suspected that religiosity and spirituality could be mapped to specific brain circuits, but the location of those circuits remains unknown. Now, a new study using novel technology and the human connectome, a map of neural connections, has identified a brain circuit that seems to mediate that aspect of our personality. The work appears in Biological Psychiatry, published by Elsevier.

31 Aug 2021

Indoor air is an important source of exposure to harmful forever chemicals, study shows

The air we breathe in our homes, schools, and workplaces can be polluted with harmful PFAS chemicals, according to a study published today in Environmental Science & Technology Letters.

31 Aug 2021

Research highlights the importance of meninges for brain development and pathology

A new study, led by researchers at the University of Gothenburg, have generated the first comprehensive transcriptional atlas of neonatal mouse meningeal leukocytes, under normal conditions and after perinatal brain injury.

31 Aug 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Life Science News

New low-cost technique helps profile dynamic metabolic features from single isogenic cells

New model shows how dysfunction in the air sacs initiates fibrotic cascade

Researchers show how a protein molecular motor can 'constrict' cell membranes

Scientists identify small compounds that can regulate extracellular vesicle production

Researchers decipher genetic mechanisms governing the speed of protein synthesis

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

$1.3 million in NIH funding to enable drug delivery technology research

Researchers develop adult lung organoids that represent all cell types

Study uses novel technology to map the brain circuitry of spirituality

Indoor air is an important source of exposure to harmful forever chemicals, study shows

Research highlights the importance of meninges for brain development and pathology

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

New, one-stop method developed to avoid de novo genetic disease in embryos

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Research sheds light on potential biological mechanisms that impact adherence to medications

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Researchers develop chemistry approach to polymerize proteins inside microbes

Discovery of new urinary biomarkers can boost the surveillance of synthetic drug abuse

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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