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Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

In a recent study posted to the bioRxiv* server, researchers at the United States Army Medical Research Institute of Infectious Diseases evaluated the immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) deoxyribonucleic acid (DNA) vaccine, nCOV-S(JET), in rhesus macaques

18 Sep 2022

An improved COVID-19 vaccine shows promise against Omicron in experimental models

In a recent study published in the journal Science Translational Medicine, researchers in the United States designed a bivalent coronavirus disease 2019 (COVID-19) vaccine on the messenger ribonucleic acid (mRNA) platform.

18 Sep 2022

Researchers identify universal features shaping organelle gene retention

Mitochondria are compartments – so-called "organelles" -- in our cells that provide the chemical energy supply we need to move, think, and live.

16 Sep 2022

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

This study is led by Dr. Ruifu Yang, Dr. Zongmin Du (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology) and Dr. Fan Bai (Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University).

16 Sep 2022

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process.

16 Sep 2022

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19's viral pathogenesis - a theory that was posited two years ago by a team of researchers at the Department of Energy's Oak Ridge National Laboratory.

16 Sep 2022

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

A Rochester Institute of Technology scientist hopes that a better understanding of how living cells maintain the size of their organelles can lead to therapies for neurodegenerative diseases.

16 Sep 2022

Deep AI models fail to capture the configural nature of human shape perception

Deep convolutional neural networks (DCNNs) don't see objects the way humans do – using configural shape perception – and that could be dangerous in real-world AI applications, says Professor James Elder, co-author of a York University study published today.

16 Sep 2022

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

Researchers at the University of Minnesota Medical School and the Institute on the Biology of Aging and Metabolism were awarded a total of $19.3 million in grants from the National Institutes of Health Common Fund to map senescent cells in preclinical studies and human tissues as part of the SenNet Consortium.

16 Sep 2022

Researchers use sea anemone to understand how behavior impacts body shape during early development

As humans, we know that an active lifestyle gives us some control over our form. When we hit the pavement, track our steps, and head to the gym, we can maintain muscle development and reduce body fat.

16 Sep 2022

Study evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants

The availability of rapid antigen tests has significantly advanced efforts to contain the spread of COVID-19, but every new variant of concern raises questions about whether diagnostic tests will still be effective.

15 Sep 2022

Machine learning can help create proteins much more accurately, quickly than previously possible

Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design.

15 Sep 2022

Discovery of 380-million-year-old heart sheds new light on the evolution of our bodies

Researchers have discovered a 380-million-year-old heart – the oldest ever found – alongside a separate fossilized stomach, intestine and liver in an ancient jawed fish, shedding new light on the evolution of our own bodies.

15 Sep 2022

Strains within gut microbial species codiversified with human populations, study finds

Strains within dozens of bacterial species in the gut microbiota codiversified with human populations as they spread across the globe, according to a new study. The findings underscore the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease and microbiota-based therapeutics.

15 Sep 2022

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 17, entitled, "Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study."

15 Sep 2022

New mechanism may prevent the natural aging of immune cells

A new mechanism that slows down and may even prevent the natural aging of immune cells – one of the nine 'hallmarks of aging' – has been identified by an international team led by UCL scientists.

15 Sep 2022

Scientists unravel the molecular origin of rare genetic disease cystinosis

The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations interfere with its normal function, providing insights into the underlying mechanisms and suggesting a way to develop new treatments for the disease.

15 Sep 2022

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

Researchers from Cleveland Clinic's Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a "priming signal" for the body to respond to a virus.

15 Sep 2022

New method evaluates how mutations to SARS-CoV-2 can affect antibody recognition in rapid antigen tests

A research team funded by the National Institutes of Health has shown that commercially available rapid antigen tests can detect past and present variants of concern and has identified potential mutations that may impact test performance in the future.

15 Sep 2022

Understanding what happens when two gut microbiomes clash together

Fecal microbiota transplantation (FMT) – the transfer of lower intestinal fluids and microbes from one individual to another – is sometimes used to treat inflammatory gut diseases, including ulcerative colitis and bacterial infections.

15 Sep 2022

Life Science News

Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

An improved COVID-19 vaccine shows promise against Omicron in experimental models

Researchers identify universal features shaping organelle gene retention

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

Deep AI models fail to capture the configural nature of human shape perception

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

Researchers use sea anemone to understand how behavior impacts body shape during early development

Study evaluates how rapid tests will perform when challenged with future SARS-CoV-2 variants

Machine learning can help create proteins much more accurately, quickly than previously possible

Discovery of 380-million-year-old heart sheds new light on the evolution of our bodies

Strains within gut microbial species codiversified with human populations, study finds

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

New mechanism may prevent the natural aging of immune cells

Scientists unravel the molecular origin of rare genetic disease cystinosis

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

New method evaluates how mutations to SARS-CoV-2 can affect antibody recognition in rapid antigen tests

Understanding what happens when two gut microbiomes clash together

Real-time Raman monitoring for pharmaceutical hot melt extrusion

Synthetic Psychedelics: A Growing Public Health Concern

How the Vutara VXL simplifies single-molecule imaging

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