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Researchers use a photostabilizer to modulate fluorescence blinking in biochemical assays

Fluorescence spectroscopy is indispensable in biomedical diagnostics. One can think of turning on fluorescence as turning on a flashlight in a dark room.

13 Apr 2021

Mouse model closely replicates human NAFLD

Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant.

13 Apr 2021

Novel ultrasensitive assay to measure cathepsin B in the blood

Scientists at the Walter Reed Army Institute for Research demonstrated the potential of a novel blood test for cathepsin B, a well-studied protein important to brain development and function, as an indicator for a range of disease states.

13 Apr 2021

Researchers discover molecular signatures of aging process in mice

Researchers have identified molecular signatures of the aging process in mice, publishing their results today in the open-access eLife journal.

13 Apr 2021

Researchers find a way to fine-tune the molecular assembly line that creates antibiotics

Researchers from North Carolina State University have found a way to fine-tune the molecular assembly line that creates antibiotics via engineered biosynthesis.

13 Apr 2021

Aged bone marrow niche restrains function of rejuvenated HSCs, shows study

When leukemia strikes an older person, it is in part due to the aging of his or her hematopoietic stem cells (HSCs).

13 Apr 2021

Natural treatment based on flour made from mealworms can help prevent Type II diabetes mellitus

Scientists from the Bioreactors Research Group of the University of Granada have demonstrated that a natural treatment based on flour made from the insect Tenebrio molitor (more commonly known as the mealworm) can help prevent Type II diabetes mellitus.

13 Apr 2021

MagnaPharm project opens up new possibilities in drug production

Polymorphs are crystalline materials that have the same chemical composition but different molecular packing. For example, diamond and graphite are both made from crystalline forms of carbon, but their physical and chemical properties vary drastically.

13 Apr 2021

Altering a mosquito's gut genes shows promise to curb malaria

Altering a mosquito's gut genes to make them spread antimalarial genes to the next generation of their species shows promise as an approach to curb malaria, suggests a preliminary study published today in eLife.

13 Apr 2021

Biology of single-celled organisms reveals potential treatment target for COPD

In a series of experiments that began with amoebas -- single-celled organisms that extend podlike appendages to move around -- Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment.

13 Apr 2021

Gene therapy may offer a new approach to preserving vision in people with retinitis pigmentosa

A gene therapy protects eye cells in mice with a rare disorder that causes vision loss, especially when used in combination with other gene therapies, shows a study published today in eLife.

13 Apr 2021

DNA supercoiling is involved in the control of gene expression

The (when stretched) two-meter-long DNA molecule in each human cell is continuously being unpacked and packed again to enable the expression of genetic information.

13 Apr 2021

Early exposure to smell can affect perception and social behavior later in life

Imprinting is a popularly known phenomenon, wherein certain animals and birds become fixated on sights and smells they see immediately after being born.

13 Apr 2021

A novel method to visualize protein channels in bacteria

Almost all bacteria rely on the same emergency valves--protein channels that pop open under pressure, releasing a deluge of cell contents.

13 Apr 2021

New approach to scale up genome editing in tiny worms

Understanding the effects of specific mutations in gene regulatory regions - the sections of DNA and RNA that turn genes on and off - is important to unraveling how the genome works, as well as normal development and disease.

13 Apr 2021

New fluorescent probe can differentiate between B and T lymphocytes

Human blood contains several different components, including plasma, red blood cells (RBCs), white blood cells (WBCs), and platelets. Among these, WBCs are divided into numerous subcategories each with unique functions and characteristics, such as lymphocytes, monocytes, neutrophils, and others.

13 Apr 2021