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A HSC surface marker plays key role in ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis.

26 Dec 2019

Researchers develop new approach for studying experience-driven activity of transcription factors

Our brains have a remarkable knack for adaptability. Each and every day the neuronal connections within are constantly changing, molded by what we experience in our daily lives.

26 Dec 2019

Inputs to the motor cortex can guide dexterous movements in mice

In a sleepy haze, reaching out and grabbing the coffee cup in front of you seems to happen on autopilot. But your caffeine-deprived brain is working hard.

26 Dec 2019

Chemical reprogramming of granulosa cells to form functional oocytes

By introducing a chemical cocktail to granulosa cells, researchers in China induced the cells to transform into functional oocytes in mice.

26 Dec 2019

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.

23 Dec 2019

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

To disarm toxic substances, many organisms - including humans - possess enzymes called flavin-containing monooxygenases. Despite their importance, the structure of the enzymes has not been resolved, as the protein is too unstable to study in detail.

23 Dec 2019

New technique provides real-time images of biomolecules in living cells

Metabolic diseases such as diabetes and obesity are ever more common globally. In addition to genetic disposition, lifestyle contributes strongly to the prevalence of these metabolic diseases.

23 Dec 2019

New, faster and cheaper method to uncover genetic variants in single cells

Researchers led by the European Molecular Biology Laboratory in Heidelberg and the Center for Bioinformatics at Saarland University in Saarbrücken, Germany, have developed a cheaper and faster method to check for genetic differences in individual cells, which outperforms existing techniques with respect to the information received.

23 Dec 2019

NIH awards $1.2 million grant for studying biomolecular interactions to inform better drug design

Biomolecules -- carbohydrates, proteins, nucleic acids, and lipids -- form the foundation of life and are responsible for carrying out every process that occurs in our bodies.

23 Dec 2019

Developing less aggressive cancer drugs that enable the immune system to recognize tumors

Doctors treat tumors mainly through surgery, radiotherapy, and chemotherapy. Over the next four years, a new project of Bielefeld University and 14 European partners will be studying targeted cancer treatments.

21 Dec 2019

Study uncovers a previously unknown subtype of muscle stem cells

Scientists have discovered a new subtype of muscle stem cells. These cells have the ability to build and regenerate new muscles, making them interesting targets for the development of gene therapies.

21 Dec 2019

Scientists successfully cultivate and characterize corpus luteum cells of cats

The reproduction of lynxes is highly mysterious. Unlike other wild cats, most lynxes are only receptive for a few days once a year.

20 Dec 2019

New 'tumor-on-a-chip' can be used to find better cancer fighting drugs

Kyoto University researchers have developed a new 'tumor-on-a-chip' device that can better mimic the environment inside the body, paving the way for improved screening of potential cancer-fighting drugs.

20 Dec 2019

Researchers develop powerful computer algorithm for large-scale genomic analysis

Haplotypes are a set of genetic variations that, located side by side on the same chromosome, are transmitted in a single group to the next generation. Their examination makes it possible to understand the heritability of certain complex traits, such as the risk of developing a disease.

20 Dec 2019

A receptor helps body cells to spot communication amongst bacteria

Bacterial infection does not automatically lead to illness; many germs only become dangerous when they occur in large numbers.

20 Dec 2019

Using artificial intelligence to disassemble hunting behavior of zebrafish into its components

What is the common ground between making a cup of tea and putting on your shoes? Both actions consist of several movements in a row.

20 Dec 2019

p53 may play a more important role in kidney cancer than previously thought

The p53 gene, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could lead to new treatments.

20 Dec 2019

Scientists identify molecular mechanisms that protect cells against mechanical stress

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified the molecular mechanisms that allow our cells to adapt to, protect themselves against, and survive mechanical stress.

20 Dec 2019

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene -- when the gene becomes mutated -- it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth.

20 Dec 2019

Atomic-level structure of cardiac sodium channel

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication.

20 Dec 2019

Life Science News

A HSC surface marker plays key role in ontogeny of hematopoiesis

Researchers develop new approach for studying experience-driven activity of transcription factors

Inputs to the motor cortex can guide dexterous movements in mice

Chemical reprogramming of granulosa cells to form functional oocytes

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

New technique provides real-time images of biomolecules in living cells

New, faster and cheaper method to uncover genetic variants in single cells

NIH awards $1.2 million grant for studying biomolecular interactions to inform better drug design

Developing less aggressive cancer drugs that enable the immune system to recognize tumors

Study uncovers a previously unknown subtype of muscle stem cells

Scientists successfully cultivate and characterize corpus luteum cells of cats

New 'tumor-on-a-chip' can be used to find better cancer fighting drugs

Researchers develop powerful computer algorithm for large-scale genomic analysis

A receptor helps body cells to spot communication amongst bacteria

Using artificial intelligence to disassemble hunting behavior of zebrafish into its components

p53 may play a more important role in kidney cancer than previously thought

Scientists identify molecular mechanisms that protect cells against mechanical stress

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

Atomic-level structure of cardiac sodium channel

Unlocking live single-cell functional insights

Fluidics in Modern Healthcare & Medical Device Innovation

How microRNA is transforming science: From discovery to diagnostics

Latest Life Science News