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New discovery casts doubt on plasma membrane models

Like planets, the body's cell surfaces look smooth from a distance but hilly closer up. An article published in Communications Biology describes implications, unknown to date, of the way data from cell surfaces are normally interpreted; i.e. as if they lacked topographic features.

14 Jan 2019

Conducting ChIP-Seq with Low Cell Numbers

An interview with Dr. Kathyrn Cunningham at SfN 2018, providing advice on carrying out Chromatin Immunoprecipitation Sequencing (ChIP-seq) with low cell numbers.

From Active Motif 14 Jan 2019

Researchers repurpose gene-editing tool CRISPR to develop better antibiotics

A University of Wisconsin-Madison researcher and his collaborators at the University of California, San Francisco have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ones.

11 Jan 2019

Novel microfluidic device for real-time detection of cholesterol in liver-on-chip cultures

In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the Department of Biomedical Engineering at Illinois Institute of Technology, Chicago has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes.

11 Jan 2019

Fluorescence Microscopy: Choosing the Right lllumination System

In this interview from SfN 2018, Michelle Gal explains the fluorescence illumination systems for fluorescence microscopy, offered by Excelitas technologies.

From Excelitas Technologies 11 Jan 2019

Bio-Rad publishes new paper on generation, characterization of complex-specific antibodies

Bio-Rad Laboratories, Inc., a global leader of life science research and clinical diagnostic products, has published new findings on the generation and characterization of drug-target complex-specific antibodies for pharmacokinetic analysis of biotherapeutics.

From Bio-Rad Laboratories 11 Jan 2019

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications.

11 Jan 2019

Life Science News

New discovery casts doubt on plasma membrane models

Conducting ChIP-Seq with Low Cell Numbers

Researchers repurpose gene-editing tool CRISPR to develop better antibiotics

Novel microfluidic device for real-time detection of cholesterol in liver-on-chip cultures

Fluorescence Microscopy: Choosing the Right lllumination System

Bio-Rad publishes new paper on generation, characterization of complex-specific antibodies

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

New method modifies blood stem cells to reverse genetic mutation that causes IPEX

New generation of chemists conducts research to further understand complex nature of lipids

Steady-state CD spectroscopy is a major structural tool in (bio)chemical analysis

Defective astrocytes linked to alpha-synuclein accumulation in Parkinson's

Researchers identify promising therapeutic option to treat multiple sclerosis

Unusual molecular regulatory mechanism discovered in unicellular parasites

New certified reference material for testing residual solvents in cannabis

High-performing MS device reaches new level in characterizing protein impurities

Bacteria on the International Space Station are adapting to survive, not to harm

Study explains why some drugs work well in ameliorating side effects of chemotherapy

Quanterix extends oncology footprint with accelerated launch of next gen SP-X platform and CorPlex validated 10-Plex

Aptamer Group and AstraZeneca to develop new drug delivery vehicles

NYSCF announce partnership with Ngene to develop new disease treatments

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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