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Biologists discover how protein clumps damage cells in Parkinson's disease

Biologists studying Parkinson's disease have long hoped to solve the mystery of the telltale "clumps." Scientists want to know how clumps of misfolded proteins damage brain cells and contribute to the disease.

21 Dec 2018

Elegant, low-cost approach enhances single-cell RNA sequencing

Droplet microfluidics has revolutionized single-cell RNA sequencing, offering a low-cost, high-throughput method for single-cell genomics. However, this method has been limited in its ability to capture complete RNA transcription information.

20 Dec 2018

Study lays foundation for addressing unresolved questions in human aging

Doctors have long observed that biological age and chronological age are not always one and the same. A 55-year-old may exhibit many signs of old age and have numerous age-related diseases, whereas an 80-year-old may be healthy and robust.

20 Dec 2018

Study reveals how Parkinson's disease protein 'buys time' for cell repair

Australian researchers have discovered how a protein linked to Parkinson's disease may protect cells such as neurons in the brain.

20 Dec 2018

Molecule discovery could hold the key to novel gene therapies for skin problems

Scientists at the University of Birmingham have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide.

20 Dec 2018

New research collaboration launches first evolutionary study to explore origins of fish that walk

A new research collaboration with support from the National Science Foundation, or NSF, begins an unprecedented study of walking cavefish to better understand the "fin-to-limb" transition that enabled the first vertebrates to walk on land more than 350 million years ago.

20 Dec 2018

Scripps Research finds molecular cause of a group of rare autoimmune disorders

A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune system attacks the body's own healthy cells.

20 Dec 2018

Novel ferrocenyl phosphines developed as potent antimalarial drugs

A team of researchers from the Singapore University of Technology and Design and Nanyang Technological University have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death.

20 Dec 2018

European scientists aim to identify causes of dementia

Dementia is common to a variety of neurodegenerative diseases such as Alzheimer's disease, Parkinson disease and Down syndrome. This common symptom is one of the major causes of disability and dependency among older people.

19 Dec 2018

Researchers synthesize new compound that inhibits replication of hepatitis C virus

A new compound that inhibits the replication of hepatitis C virus in several stages of its lifecycle - and is also capable of acting on bacteria, fungi and cancer cells - has been synthesized by researchers at São Paulo State University in Brazil.

19 Dec 2018

Study uncovers initial folding mechanism of membrane proteins, key in design of new drugs

An international team coordinated by the Interdisciplinary Research Structure in Biotechnology and Biomedicine of the University of Valencia has proved how the folding of membrane proteins begins before they are inserted into biological membranes, a fact that has been central to the biochemical research for decades.

19 Dec 2018

Study investigates why mammals' sense of smell deteriorates in old age

As mammals age, their sense of smell deteriorates. In a study published in the journal 'Cell Reports', an interdisciplinary research team at Helmholtz Zentrum München and the University Medical Centre Mainz investigated why this is the case.

19 Dec 2018

DNA “webs” shown to promote metastasis in ovarian cancer

Researchers have found that neutrophils cast DNA “webs” that aid the spread of ovarian cancer cells to new tissues (a process known as metastasis).

19 Dec 2018

Researchers uncover genes that play a key role in the inactivation of X chromosomes

In cell biology, men and women are unequal: men have an X chromosome, while women have two. How can we get around this difference?

19 Dec 2018

University of Marburg team celebrates success at 2018 IGEM Giant Jamboree competition

At the 2018 iGEM Gaint Jamboree, the team of the University of Marburg won the Grand Prize in the overgraduate section with their project “VibriGens – Accelerating SynBio”. At the end of October the team received its award in Boston, USA.

From BMG LABTECH GmbH 19 Dec 2018

Horizon Discovery partners with C4XD to validate novel synthetic lethal oncology targets

Horizon Discovery Group today announces that it has entered into an exclusive target discovery partnership with C4XD, a pioneering drug discovery company.

From Revvity 19 Dec 2018

Developing the Next Generation of Water-soluble DREADDs

An interview with James Flanaghan, discussing the uses of DREADDs in neurobiological research and the advantages of water-soluble ligands.

From Hello Bio 19 Dec 2018

Study reveals how stem cells can be induced to differentiate into various ocular lineages

The discovery of pluripotent stem cells, which have the ability to differentiate into the huge range of different cell lineages that make up the human body, signaled the start of a new era in biological science and medicine. Although we are also now able to reprogram regular cells to exhibit this pluripotency, we still have much to learn about the different cues that lead such cells towards a particular cell fate, including the cells that make up the eye.

19 Dec 2018

Research papers reveal an exemplar of male parental care in the animal kingdom

Stay-at-home dads might find their spirit animal in the smooth guardian frog of Borneo. A new pair of research papers authored by an investigator at the University of Kansas shows the male of the smooth guardian frog species (Limnonectes palavanensis) is a kind of amphibian "Mr. Mom" -- an exemplar of male parental care in the animal kingdom.

19 Dec 2018

Gut microbiome plays role in immune system regulation, study finds

Scientist have long known that bacteria in the intestines, also known as the microbiome, perform a variety of useful functions for their hosts, such as breaking down dietary fiber in the digestive process and making vitamins K and B7.

19 Dec 2018