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COST Action bridges the gap in cancer immunotherapy research

Cancer is still a leading cause of death worldwide. Globally, there were an estimated 20 million new cases of cancer and 10 million deaths.

20 Jan 2024

RecA protein skips "unwinding" step in DNA repair

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

20 Jan 2024

COVID-19-associated blood plasma inflammatory factors do not affect blood-brain barrier, study shows

It is now well documented that the coronavirus outbreak triggered a global health crisis. In this study, researchers wanted to know whether blood-brain barrier impairment contributed to the development of neurological problems during COVID-19 progression, and to what extent.

19 Jan 2024

Immune checkpoint inhibitor target found to promote skin cancer growth

Programmed cell death 1 (PD-1) is an important target for immune checkpoint inhibitor therapies that block its signaling and boost T-cell activity. PD-1 inhibitors have been approved for treating various types of cancer.

19 Jan 2024

Using AI to break the opioid addiction cycle

When Ben Brown, research assistant professor of chemistry, thinks about the opioid epidemic, he views the problem on a molecular level.

19 Jan 2024

Study reveals disparities in emergency department restraint use by race and ethnicity

A new study that contributes additional data to a growing body of evidence demonstrating disparities in restraint use in the emergency department (ED) has been published in the January issue of Academic Emergency Medicine (AEM), the peer-reviewed journal of the Society for Academic Emergency Medicine (SAEM).

19 Jan 2024

Montana’s effort to expand religious exemptions to vaccines prompts political standoff

Montana lawmakers are in a standoff with the state's health department over a package of sweeping changes to child care licensing rules that includes a disputed provision to allow religious exemptions to routine vaccinations for children and workers.

19 Jan 2024

Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

Memory T cells learn and adapt: Post-Omicron immunity offers wider protection

It has been 4 years since the start of the COVID-19 pandemic. SARS-CoV-2 has yet to be eradicated and new variants are continuously emerging.

19 Jan 2024

Biodesign needs open-ended systems for future innovation

Scientists working on biological design should focus on the idiosyncrasies of biological systems over optimization, according to new research.

19 Jan 2024

Antiviral hope emerges as viruses linked to multiple myeloma

A few years ago, a patient was cured of multiple myeloma after being treated for hepatitis C, astounding researchers from the group led by Joaquín Martínez, from the H12O-CNIO Haematological Tumours Clinical Research Unit, a collaboration between the Hospital 12 de Octubre (H12O) and the National Cancer Research Centre (CNIO).

19 Jan 2024

Tailored opioid prescribing limits more effective at reducing prescription length, study finds

Many states have passed new laws that place restrictions on the duration of first-time opioid prescriptions to help address the opioid epidemic.

19 Jan 2024

New instruction manual could help scientists find hard-to-detect B cells

Researchers with McMaster University have created the instruction manual that will help scientists across the globe find hard-to-detect B cells.

19 Jan 2024

New research center seeks to harness the positive powers of fungi

A new research center focused on harnessing the positive powers of fungi is being established at Cranfield University with a £7.2 million injection of funding from Research England.

19 Jan 2024

Engaging partners in the breastfeeding journey

The most important support person for women to succeed in their ambition to breastfeed is the new mother's partner. The partner also needs to be included through more support from healthcare professionals.

19 Jan 2024

£1.9M funding supports research into drivers of health disparities and associated infectious disease burden

Dr Rosalind Eggo, an Associate Professor of Infectious Disease Modelling at the London School of Hygiene & Tropical Medicine (LSHTM), has been awarded over £1.9 million funding to lead research into drivers of health disparities and associated infectious disease burden across England.

19 Jan 2024

Annexin-A1 targeted therapy beats several cancers

A new study published in Nature's cancer journal Oncogene highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumour progression.

19 Jan 2024

Women using drugs and alcohol can feel stigmatized when seeking treatment

Women using drugs and alcohol can feel stigmatized and shamed when seeking support from professional services, a new study has found.

19 Jan 2024

AI scores breakthrough in anemia treatment with novel PHD inhibitor

Clinical stage generative artificial intelligence (AI)-driven biotechnology company InSilico Medicine ("InSilico"), today announced that the Journal of Medicinal Chemistry, an ACS Publications journal focusing on critical studies about molecular structure and biological activity, has published the company's discovery of a novel PHD inhibitor for the treatment of anemia.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024