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Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation

Researchers identify a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Calorie labeling can help people choose slightly fewer calories

A new Cochrane review has found that calorie labelling of food on menus and products leads people to choose slightly fewer calories.

17 Jan 2025

Intestinal bacterium found to reduce sugar intake in diabetic mice and humans

Excessive sugar consumption is linked to several non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes.

17 Jan 2025

Over 500 European patients diagnosed through groundbreaking genetic research

More than 500 European patients with unknown conditions have received a diagnosis through new genetic research.

17 Jan 2025

Early brain changes in Huntington’s disease detected two decades before symptoms

Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's disease, finds a new study led by UCL researchers.

17 Jan 2025

Junk food turns public villain as power shifts in Washington

The new Trump administration could be coming for your snacks. For years, the federal government has steered clear of regulating junk food, fast food, and ultra-processed food.

17 Jan 2025

For homeless seniors, getting into stable housing takes a village — and a lot of luck

Over two years ago, Kim Hilton and his partner walked out of their home for the final time. The house had sold, and the new landlord raised the rent.

17 Jan 2025

BIOHIT secures European distribution rights for Biomedal’s gluten immunogenic peptide tests

BIOHIT is excited to announce an agreement with Biomedal to supply its iVYLISA, iVYCHECK and GlutenDetect gluten immunogenic peptide (GIP) tests.

17 Jan 2025

New research identifies metabolic targets to combat antibiotic-resistant bacterial infections

Targeting unique metabolic pathways in pathogens offers a novel approach to precision antibiotics, addressing the growing challenge of antimicrobial resistance.

17 Jan 2025

Brain neurons that respond to sugar and fat offer new insights into obesity control

The study uncovers hippocampal neurons that differentially respond to sugars and fats, suggesting new avenues for combating obesity through targeted therapies.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Triple-drug chemo fails to improve survival in advanced biliary tract cancer

The results of a clinical trial led by researchers at the University of Arizona Health Sciences and published in the Journal of Clinical Oncology showed that chemotherapy combining three different types of drugs did not improve overall survival for patients with advanced stage, inoperable biliary tract cancers.

17 Jan 2025

Swedish study demonstrates significant reduction in infant mortality after 41 weeks gestation

The proportion of babies dying before and during labor after 41 weeks of gestation has fallen by 47% in Sweden in a relatively short time. This is the result of a major national study. The reduction has occurred since the procedures around induction have changed.

17 Jan 2025

Unveiling the metabolic pathways of Fusobacterium nucleatum in OSCC

A recent study has made significant strides in uncovering how the oral microbiome, particularly the bacterium Fusobacterium nucleatum, plays a crucial role in the progression of oral squamous cell carcinoma (OSCC). By identifying key interactions between this common oral bacterium and host cells, the research has unveiled important metabolic pathways and mechanisms that may serve as potential therapeutic targets.

17 Jan 2025

Study reveals high prevalence of Lyme disease bacteria in Northeast ticks

Across most of the Northeast, getting bitten by a blacklegged tick- also called a deer tick - is a risk during spring, summer, and fall. A new Dartmouth study, published in Parasites and Vectors, finds that 50% of adult blacklegged ticks carry the bacteria that causes Lyme disease while 20% to 25% of the younger (nymph) blacklegged ticks carry the bacteria.

17 Jan 2025

New approach shows promise in fighting multiple cancers

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor's cancerous cells influence their surroundings, blocking the body's immune defenses and creating a sort of haven in which the tumor can grow. Treatments that target some of these pro-tumor actions are effective in a number of cancers, but only for some patients; in others, these treatments have little effect.

17 Jan 2025

Oil-based solution enables room temperature storage of protein therapeutics

A new storage technique can keep protein-based drugs and vaccines stable without keeping them cold. The discovery, led by researchers at Penn State, could eliminate the need for refrigeration for hundreds of life-saving medicines like insulin, monoclonal antibodies and viral vaccines.

17 Jan 2025

Bidirectional movement drives DNA loop formation

Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes.

17 Jan 2025

Explainable AI predicts ICU length of stay and guides clinical decision-making

Intensive care units (ICUs) face mounting pressure to effectively manage resources while delivering optimal patient care. Groundbreaking research published in the INFORMS journal Information Systems Research highlights how a novel artificial intelligence (AI) model is revolutionizing ICU care by not only improving predictions of patient length of stay, but also equipping clinicians with clear, evidence-based insights to guide critical decisions.

17 Jan 2025