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Using untargeted metabolomics to find biomarkers and therapeutic targets for CVD

Cardiovascular diseases are proven to be the leading cause of deaths throughout the world. If statistics are reviewed, almost four out of five deaths are due to myocardial infarction or stroke. Efforts to prevent CVD have little effect on the decrease of the number of CVD related deaths despite many medical advances.

26 Dec 2018

Study investigates role of miRNAs in anesthetic-induced myocardial conditioning

Many studies have shown that the mechanism of drug-induced myocardial conditioning is enzyme-mediated through messenger RNA and miRNA regulation. In this study Orriach et al. investigated the role that miRNAs play in the cardio-protective effect of halogenated anesthetics, which are widely used in cardiac surgery.

26 Dec 2018

New method of cancer stem cells activation to destroy tumors

This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.

26 Dec 2018

Lupin partners with Abbvie to develop and commercialize new targeted oncology treatments

Pharma major Lupin Limited and global biopharmaceutical company AbbVie Inc., today announced that AbbVie has licensed Lupin's MALT1 (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1) inhibitor program.

25 Dec 2018

New mechanism may explain neurons shrinking in Huntington's disease

A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites -- long finger-like extensions that make connections all through the brain -- become smaller.

25 Dec 2018

Brain activity found to be predictive of pain-related fear

Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient's fear of pain. This neuroscientific approach, reported in eNeuro, may help reconcile self-reported emotions and their neural underpinnings.

25 Dec 2018

Neuroimaging study explores how socioeconomic status shapes developing brains

The relationship between socioeconomic status and brain anatomy is mostly stable from childhood to early adulthood, according to a longitudinal neuroimaging study of more than 600 healthy young people published in JNeurosci.

25 Dec 2018

Study reveals side effects of breast cancer drug on brain function

A comprehensive study of monkeys given the breast cancer drug letrozole reveals side effects that impact the brain. Published in JNeurosci, the research establishes the common marmoset as an important nonhuman primate model for studying the effects of estrogen-reducing treatments on the nervous system.

25 Dec 2018

The role of galanin-like peptide in regulating feeding behavior and energy metabolism

Galanin-like peptide is a short peptide made up of 60 amino acid residues. This sequence is homologous across several species. The hypothalamic arcuate nucleus is the place where GALP is produced. GALP has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior.

25 Dec 2018

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Children with life-threatening respiratory failure who require mechanical ventilation in a pediatric intensive care unit commonly experience rapid muscle atrophy, according to a study published online Dec. 19, 2018, in PLOS ONE.

24 Dec 2018

Study shows paramedics can safely assess psychiatric patients’ medical condition in the field

Emergency medical personnel in Alameda County, California, use a screening process for determining whether to "medically clear" patients experiencing psychiatric emergencies before transporting them.

24 Dec 2018

Traditional and new imaging methods used for prostate cancer diagnosis

Prostate cancer is the second prevent type of cancer that exists. Prostate cancer is usually a slowly progressing disease but it can sometimes manifest as an aggressive cancer. Prostate imaging is the primary way to diagnose the disease and this necessity drives its demand in the clinic.

24 Dec 2018

Scientists discover two therapies that slow progression of pediatric leukemia in mice

Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development.

24 Dec 2018

Study: Overlapping surgery is safe for patients undergoing outpatient orthopedic procedures

At least for brief periods, overlapping surgery is safe for patients undergoing outpatient or "same-day" orthopedic surgery procedures, reports a study in the December 19, 2018 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

24 Dec 2018

Simple tests in GP surgeries could increase diagnosis rate of liver disease

Research carried out by scientists at the University of Southampton has shown that simple tests in GP surgeries could potentially double the diagnosis rate of liver disease where patients are not displaying any symptoms.

24 Dec 2018

Kidney patients have the highest number of comorbidities, shows study

A study published in JAMA Network Open showed: nephrologists treat the most complex patients. As ERA-EDTA president Professor Carmine Zoccali explains, kidney patients are highly vulnerable and need special care, but nephrology is a neglected discipline in many European healthcare systems.

24 Dec 2018

Researchers report uncertainty around long-term effectiveness of medications to control knee osteoarthritis pain

Managing osteoarthritis requires long-term treatment for symptoms such as pain and changes in joint structure that can lead to disability.

24 Dec 2018

The impact of maternal diabetes on fetal heart development

Congenital heart disease is the most common birth defect. And even with remarkable advances in care, it remains the leading cause of non-infectious death in infants.

24 Dec 2018

Harvard researchers develop new soft, non-toxic wearable sensor

Children born prematurely often develop neuromotor and cognitive developmental disabilities. The best way to reduce the impacts of those disabilities is to catch them early through a series of cognitive and motor tests.

24 Dec 2018

Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

In the largest genetic analysis of polycystic ovary syndrome (PCOS) performed to date, an international consortium, including researchers at the Icahn School of Medicine at Mount Sinai, conducted a whole genome association study to identify common genetic architecture for different diagnostic criteria used to define the syndrome.

24 Dec 2018

Medical News

Using untargeted metabolomics to find biomarkers and therapeutic targets for CVD

Study investigates role of miRNAs in anesthetic-induced myocardial conditioning

New method of cancer stem cells activation to destroy tumors

Lupin partners with Abbvie to develop and commercialize new targeted oncology treatments

New mechanism may explain neurons shrinking in Huntington's disease

Brain activity found to be predictive of pain-related fear

Neuroimaging study explores how socioeconomic status shapes developing brains

Study reveals side effects of breast cancer drug on brain function

The role of galanin-like peptide in regulating feeding behavior and energy metabolism

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Study shows paramedics can safely assess psychiatric patients’ medical condition in the field

Traditional and new imaging methods used for prostate cancer diagnosis

Scientists discover two therapies that slow progression of pediatric leukemia in mice

Study: Overlapping surgery is safe for patients undergoing outpatient orthopedic procedures

Simple tests in GP surgeries could increase diagnosis rate of liver disease

Kidney patients have the highest number of comorbidities, shows study

Researchers report uncertainty around long-term effectiveness of medications to control knee osteoarthritis pain

The impact of maternal diabetes on fetal heart development

Harvard researchers develop new soft, non-toxic wearable sensor

Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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