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A new AI tool for unlocking the secrets of spatial multi-omics in cancer

A new artificial intelligence-powered tool called MISO (Multi-modal Spatial Omics) can detect cell-level characteristics of cancer by looking at data from extremely small pieces of tissue-some as small as 400 square micrometers, equivalent to the width of five human hairs.

16 Jan 2025

Researchers develop a computational model of grid cell-mediated episodic encoding

Nearly 50 years ago, neuroscientists discovered cells within the brain's hippocampus that store memories of specific locations. These cells also play an important role in storing memories of events, known as episodic memories. While the mechanism of how place cells encode spatial memory has been well-characterized, it has remained a puzzle how they encode episodic memories.

16 Jan 2025

Targeting tertiary lymphoid structures for cancer treatment

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell clusters called tertiary lymphoid structures (TLSs) in response to foreign threats such as cancer.

16 Jan 2025

Mouse protein disrupts cancer-causing epigenetic changes in human colorectal cancer

A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study from researchers at the Johns Hopkins Kimmel Cancer Center and the Chinese Academy of Sciences.

16 Jan 2025

Leveraging CGP and ctDNA for improved cancer outcomes

Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA (ctDNA), in tandem with data from comprehensive genomic profiling (CGP).

16 Jan 2025

Unveiling the genetic roots of bicuspid aortic valve

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease, according to a new study led by UTHealth Houston researchers.

16 Jan 2025

Unmasking the gender bias in Tourette syndrome diagnosis

Tourette syndrome is currently diagnosed about three times more frequently in males than in females. A new study finds that female individuals are less likely to be diagnosed with the syndrome, take longer to receive a diagnosis and are older when they are diagnosed than male individuals. The study is published in the January 15, 2025, online issue of Neurology®, the medical journal of the American Academy of Neurology.

16 Jan 2025

T-DM1 reduces long-term risk of death in HER2-positive breast cancer patients

In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the phase 3 KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.

16 Jan 2025

CGM data offers superior insights into diabetes complications

Data from continuous glucose monitors can predict nerve, eye and kidney damage caused by type 1 diabetes, University of Virginia Center for Diabetes Technology researchers have found. That suggests doctors may be able to use data from the devices to help save patients from blindness, diabetic neuropathy and other life-changing diabetes complications.

16 Jan 2025

Tiny vesicles offer powerful new approach for cancer treatment

A new twist on a decades-old anticancer strategy has shown powerful effects against multiple cancer types in a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

16 Jan 2025

Xenon gas offers potential neuroprotective effects for Alzheimer's patients

Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research from Mass General Brigham and Washington University School of Medicine in St. Louis points to a novel-and noble-approach: using Xenon gas.

16 Jan 2025

Unlocking the neural basis of overeating

Can memory influence what and how much we eat? A groundbreaking Monell Chemical Senses Center study, which links food memory to overeating, answered that question with a resounding "Yes." Led by Monell Associate Member Guillaume de Lartigue, PhD, the research team identified, for the first time, the brain's food-specific memory system and its direct role in overeating and diet-induced obesity.

16 Jan 2025

Antihistamine shows promise for treating rare genetic liver disease

A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health.

16 Jan 2025

Experts call for national strategy to address alcohol-related harms in the UK

The UK needs an overarching national strategy to tackle alcohol related harms, argue experts in The BMJ today, as deaths from alcohol in England reach their highest level on record.

16 Jan 2025

Exercise offers hope in the Alzheimer's battle

Regular aerobic exercise could significantly reduce disease markers associated with Alzheimer's, new research led by scientists at the University of Bristol (UK) and the Federal University of São Paulo (Brazil) has found. The findings provide new hope in the battle against this devastating disorder.

16 Jan 2025

Air pollution before conception may increase child BMI

In a study of more than 5,000 mothers and their children, exposure to air pollution during the three months before pregnancy predicted higher child body mass index (BMI) and related obesity risk factors up to two years of age.

15 Jan 2025

Review highlights the pathogenesis and clinical spectrum of Nipah virus infection

Nipah virus (NiV), a zoonotic paramyxovirus with significant human health implications, has garnered considerable attention due to its high fatality rates and potential for human-to-human transmission, posing a global public health threat.

15 Jan 2025

The Christie launches unique training program for cancer care doctors

A unique training programme for a new breed of cancer care doctors is underway at The Christie in Manchester, an international center of excellence in cancer care.

15 Jan 2025

Grifols receives grant for early Parkinson's disease biomarker discovery

Grifols, a global healthcare company and leading producer of plasma-derived medicines, today announced it has received a grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to identify plasma-based biomarkers that could indicate a person’s likelihood of developing Parkinson’s disease (PD) many years before clinical diagnosis.

15 Jan 2025

Pheno Therapeutics receives clinical trial authorization for novel multiple sclerosis therapeutic

Pheno Therapeutics Limited., a biotechnology company focused on the discovery and development of small molecule therapeutics for the treatment of neurological diseases, announced today it has received clinical trial authorization (CTA) from the UK’s MHRA (Medicines and Healthcare products Regulatory Agency) for its lead candidate, PTD802.

15 Jan 2025