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CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024

Fox Chase Cancer Center researchers identify new targets for mesothelioma prevention

A new research perspective was published in Oncoscience (Volume 11) on May 23, 2024, entitled, "Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma."

19 Jul 2024

New national guidelines for anal cancer prevention in HIV patients based on UCSF research

New recommendations for screening and treatment are based on the results of a major national study led at UCSF.

19 Jul 2024

UVA advances precision medicine to defeat breast cancer with Komen grant

Through precision medicine, the University of Virginia is working toward a world in which no more pink ribbons are necessary. To that end, Susan G. Komen announced support this summer for the UVA School of Engineering and Applied Science's efforts to apply systems biology research to defeat breast cancer.

19 Jul 2024

Life expectancy in India suffered large and unequal declines during COVID-19 pandemic

The international study, co-authored by the Department of Sociology and the Leverhulme Centre for Demographic Science's Dr Aashish Gupta and Professor Ridhi Kashyap, reveals that life expectancy in India suffered large and unequal declines during the COVID-19 pandemic.

19 Jul 2024

Marshall University receives $3.3 million grant to examine genetic mechanisms behind fentanyl addiction

Marshall University was awarded a $3.3 million grant (#R01DA057931) from the National Institute on Drug Abuse (NIDA) to examine the genetic mechanisms that underlie fentanyl addiction.

19 Jul 2024

Leptospirosis research uncovers key factors in disease transmission

Corkscrew-shaped Leptospira and the potentially deadly disease they cause are tricky to study. The bacteria live in the kidneys of animals where they may or may not cause symptoms, and they are readily released into the environment whenever their host urinates.

19 Jul 2024

Discovery of key RSV immune evasion mechanism offers hope for new treatments

Irish scientists led by a group from Trinity College Dublin have discovered how the dangerous Respiratory Syncytial Virus (RSV) defuses our immune response and, in doing so, they have pinpointed an exciting new target for drug developers.

19 Jul 2024

Unexpected T-cell reactions to adenoviral COVID-19 vaccines discovered

Researchers from the University of Liverpool's Centre for Drug Safety Science have identified unpredicted T-cell immune responses to the adenoviral (Oxford/AstraZeneca and Janssen) COVID-19 vaccines, but not to the mRNA vaccines.

19 Jul 2024

New microscopy technique unveils dynamic structure of amyloid-beta

Amyloid-beta (A-beta) aggregates are tangles of proteins most notably associated with neurodegenerative diseases like Alzheimer's.

19 Jul 2024

Biden administration tightens broker access to healthcare.gov to thwart rogue sign-ups

The Biden administration on Friday put in place stringent curbs aimed at thwarting rogue insurance brokers from switching consumers' Affordable Care Act plans without their consent.

19 Jul 2024

Study offers insight into incarceration's toll on youth health

Researcher Samantha Boch has studied the impact of incarceration on child and family health for more than a decade.

19 Jul 2024

Research may pave the way for systemic targeted therapy for patients with pseudomyxoma peritonei

Published in Clinical Cancer Research, results of a preclinical study led by investigators of the Vall d'Hebron Institute of Oncology's (VHIO) Stem Cells and Cancer Group, headed by Héctor G. Palmer, pave the way for systemic targeted therapy in patients with pseudomyxoma peritonei, a rare form of cancer with very few therapeutic options available.

19 Jul 2024

Stroop-CN: A rapid diagnostic tool for minimal hepatic encephalopathy

This study is led by Dr. Xiaolong Qi (Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology) and Dr. Junliang Fu (Senior Department of Infectious Diseases, the Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases).

19 Jul 2024

Study highlights the link between urinary and vaginal pathogenic E. coli in recurrent cystitis

The human body hosts a diverse array of microorganisms that maintain a delicate balance crucial for overall health.

19 Jul 2024

New screening tool uses infrared light and machine learning to detect multiple health conditions

Using infrared light and machine learning, researchers have developed a method to effectively screen human health and its deviations at a population level.

19 Jul 2024

Extreme heat alert: Understanding the impact of heatwaves on public health

According to a joint heat-health warning issued by the UK Health Security Agency (UKHSA) and Met Office, parts of the UK are forecast to experience heatwave conditions as temperatures rise over the next few days in July.

19 Jul 2024

Collaborative grant program boosts health research across Tennessee

Researchers from the University of Tennessee Health Science Center College of Medicine-Knoxville; the University of Tennessee, Knoxville; and the University of Tennessee Health Science Center Office of Research understand the challenges affecting the health and wellness of Tennesseans.

19 Jul 2024

How maternal scent enhances face perception in infants aged 4-12 months

Humans see the world through the five senses, but how and when the ability to integrate across the senses arises is debated.

19 Jul 2024

Physical modulation of the tumor microenvironment to enhance cancer therapy

Announcing a new article publication for BIO Integration journal. The tumor microenvironment (TME) has a crucial role in tumor development, metastasis, and recurrence.

19 Jul 2024

Medical News

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

Fox Chase Cancer Center researchers identify new targets for mesothelioma prevention

New national guidelines for anal cancer prevention in HIV patients based on UCSF research

UVA advances precision medicine to defeat breast cancer with Komen grant

Life expectancy in India suffered large and unequal declines during COVID-19 pandemic

Marshall University receives $3.3 million grant to examine genetic mechanisms behind fentanyl addiction

Leptospirosis research uncovers key factors in disease transmission

Discovery of key RSV immune evasion mechanism offers hope for new treatments

Unexpected T-cell reactions to adenoviral COVID-19 vaccines discovered

New microscopy technique unveils dynamic structure of amyloid-beta

Biden administration tightens broker access to healthcare.gov to thwart rogue sign-ups

Study offers insight into incarceration's toll on youth health

Research may pave the way for systemic targeted therapy for patients with pseudomyxoma peritonei

Stroop-CN: A rapid diagnostic tool for minimal hepatic encephalopathy

Study highlights the link between urinary and vaginal pathogenic E. coli in recurrent cystitis

New screening tool uses infrared light and machine learning to detect multiple health conditions

Extreme heat alert: Understanding the impact of heatwaves on public health

Collaborative grant program boosts health research across Tennessee

How maternal scent enhances face perception in infants aged 4-12 months

Physical modulation of the tumor microenvironment to enhance cancer therapy

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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