Seattle Genetics starts Brentuximab Vedotin retreatment trial

NewsGuard 100/100 Score

Seattle Genetics, Inc. has announced that it has initiated a phase II clinical trial of brentuximab vedotin (SGN-35), an antibody-drug conjugate (ADC), for the retreatment of patients with Hodgkin lymphoma and systemic anaplastic large cell lymphoma (ALCL).

This trial is designed to evaluate tolerability and activity when retreating patients who relapse after previously achieving an objective response to brentuximab vedotin.

The phase II multi-center trial will assess safety and antitumor response to retreatment with brentuximab vedotin. The trial is designed to enroll up to 50 patients with relapsed or refractory Hodgkin lymphoma or systemic ALCL who have previously achieved a complete or partial response to therapy with brentuximab vedotin. Patients will receive 1.8 milligrams per kilogram of brentuximab vedotin every three weeks.

Brentuximab vedotin is in an ongoing pivotal trial under a Special Protocol Assessment (SPA) from the U.S. Food and Drug Administration (FDA) for relapsed or refractory Hodgkin lymphoma and a phase II trial for systemic ALCL. The company also is conducting a phase I clinical trial assessing weekly dosing of brentuximab vedotin. Brentuximab vedotin has received fast track designation from the FDA for Hodgkin lymphoma as well as orphan drug designation in the United States and Europe for both Hodgkin lymphoma and ALCL.

Brentuximab vedotin is an ADC comprising an anti-CD30 antibody attached by an enzyme cleavable linker to a potent, synthetic drug payload, monomethyl auristatin E (MMAE), using Seattle Genetics’ proprietary technology. The ADC is designed to be stable in the bloodstream, but to release MMAE upon internalization into CD30-expressing tumor cells, resulting in targeted cell-killing.

http://www.seattlegenetics.com

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Genetics studies have a diversity problem that researchers struggle to fix