MAKO sells 13 Robotic Arm Interactive Orthopedic Systems during fourth quarter 2010

Fourth Quarter 2010 and Full Year Highlights

Thirteen RIO® Systems Sold in the Quarter, Increasing Domestic Commercial Installed Base to 67 RIO Systems

Total of 33 RIO Systems Sold Worldwide in 2010

1,146 MAKOplasty® Procedures Performed in the Quarter, a 104% Increase Over the Same Period in 2009

Total of 3,485 MAKOplasty® Procedures Performed in 2010, a 118% Increase Over the Same Period in 2009

MAKO Surgical Corp. (Nasdaq:MAKO), a medical device company that markets both its RIO® Robotic Arm Interactive Orthopedic surgical platform and proprietary RESTORIS® implants for minimally invasive orthopedic procedures known as MAKOplasty®, today announced its selected operating results for its fourth quarter ended December 31, 2010 in anticipation of its business update presentation at the 29th Annual J.P. Morgan Healthcare Conference at the Westin St. Francis Hotel in San Francisco on Wednesday, January 12, 2011 at 2:30 pm PST.

MAKO will provide a live webcast of the business update presentation. Interested parties may access the live webcast by visiting the investor relations section of MAKO's web site at www.makosurgical.com. A replay of the webcast will be available at the site after the live presentation.

2010 Fourth Quarter and Full Year Review

RIO Systems – Thirteen RIO systems were installed and customer accepted at commercial sites during the fourth quarter. A total of 33 new RIO systems were sold worldwide in 2010 and MAKO's domestic commercial installed base of RIO systems totaled 67 as of December 31, 2010.

MAKOplasty Procedure Volume – During the fourth quarter, 1,146 MAKOplasty procedures were performed, of which 1,142 procedures were performed at domestic sites, and our clinical research site in Glasgow, Scotland reported that four procedures were performed at its site. The 1,146 MAKOplasty procedures represent a 41% increase over procedures performed in the third quarter of 2010 and a 104% increase over the fourth quarter of 2009. The average monthly utilization per system was 6.7 procedures during the fourth quarter of 2010, an increase from 5.7 procedures per system per month in the third quarter of 2010 and 6.0 procedures per system per month in the fourth quarter of 2009. The average monthly utilization per system for the year ended December 31, 2010 was 6.4. A total of 3,485 MAKOplasty procedures were performed in 2010 and through December 31, 2010, a total of 5,869 procedures have been performed since the first procedure in June 2006.

"We are pleased that our ongoing focus on execution has continued to produce strong operating results," said Maurice R. Ferre, M.D., President and Chief Executive Officer of MAKO. "We are also pleased that we continue to experience strong adoption of MAKOplasty by surgeons and hospitals."