Shionogi-ViiV Healthcare initiates 572-Trii fixed-dose combination therapy study for HIV

Shionogi-ViiV Healthcare, LLC announced today that the first patient has entered the clinical study, SINGLE (ING114467), designed to support a new fixed-dose combination (FDC) therapy for the treatment of HIV.  The new investigational regimen, known as 572-Trii, will combine the investigational integrase inhibitor S/GSK1349572 ('572) and ViiV Healthcare's combination nucleoside reverse transcriptase inhibitor (NRTI) Kivexa®/Epzicom® (ABC/3TC).

"ViiV Healthcare's goal is to understand and be responsive to the needs of people living with HIV," stated Dominique Limet, Chief Executive Officer, ViiV Healthcare. "With this programme, we are seeking to create an integrase-based, once-daily fixed dose combination that helps meet  patient needs.  We know that even with the successes of current therapies, patients still need additional treatment options and we will continue to evaluate existing and pipeline compounds for new combination therapies."  

"The study of a fixed-dose combination therapy that includes '572 is a signal of Shionogi and ViiV Healthcare's confidence in the compound's potential," said Dr. Sapan Shah, President & CEO, Shionogi Inc. "We're optimistic that '572 will continue to show promise through this research and in the other ongoing Phase III studies that are evaluating it in other HIV treatment regimens."