Researchers develop better method to identify areas with highest prostate cancer burden

NewsGuard 100/100 Score

To catch prostate cancer at earlier stages, when it's more easily treated, many institutions do community outreach and education sessions to explain why cancer screenings can be life-saving. In order to have the highest impact, however, institutions must select where to focus their efforts. Prostate cancer is most common among African American men and can be more aggressive in African American and men in a low socioeconomic bracket. Therefore, many institutions base their outreach on these two demographic factors. However, work recently published in the journal Preventive Medicine shows that this may not be the best approach and offers another method for identifying areas with the highest prostate cancer burden.

"We know that not every man in a high risk demographic will develop prostate cancer," said senior author Charnita Zeigler-Johnson, PhD, MPH, researcher with the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health, one of only 69 NCI-Designated Centers and only one of eight to have a prostate cancer program of excellence. "We've seen that often the same programs and organizations are targeted for education and outreach efforts. We realized that we're probably leaving out large areas of the city that potentially have higher risk. I wanted to create a more effective tool to find those areas."

To do that, Dr. Zeigler-Johnson's team including SKCC Consortium partners crunched data from the Pennsylvania Cancer Registry that covered a span of nine years (from 2005 to 2014) and looked specifically at prostate cancer cases in the city of Philadelphia. Using that data as a starting point the researchers then created a prostate cancer composite score that would help identify census tracts with the highest burden of prostate cancer. The score was based on three factors: 1) a standardized incidence ratio (SIR), which measures how much more likely a population is to get cancer compared to national rates 2) mortality ratio, which similarly determines the rate of death from prostate cancer compared to national rates and 3) how advanced the prostate cancer was at diagnosis.

"None of these factors alone can be used to categorize burden of the disease. We found they were more predictive when combined," said Dr. Zeigler-Johnson, who is also Assistant Professor of Medical Oncology at Jefferson (Philadelphia University + Thomas Jefferson University.

The researchers then used mapping software to geographically identify census tracts with the highest scores. "We were surprised to find clusters of high burden that did not always overlap with the areas with the largest concentrations of African Americans or those with lowest socioeconomic status measures," said first author Russell McIntire, PhD, MPH, an Assistant Professor in the Jefferson College of Population Health.

"We are seeing the highest prostate cancer burden cluster in tight geographic areas," said Dr. Zeigler-Johnson, whose earlier work suggested similar trends. "We think it's worth studying why these areas of the city are at higher risk for poor prostate cancer outcomes. Could it be that neighborhoods share similar practices and norms, or lack of awareness about prostate cancer risk? At this point it's too early to tell."

Although the tool was developed for prostate cancer, the method could be developed and applied to other cancer types in order to hone educational outreach efforts for the greater impact.

Now that Dr. Zeigler-Johnson and colleagues have identified areas of high prostate cancer risk in Philadelphia, they will develop, implement, and test an educational outreach program. "Testing our assumptions in the community will help us determine if this tool can be more effective than outreach targeted using traditional methods," said Dr. Zeigler-Johnson.



  1. Armando Fernandez Armando Fernandez United States says:

    Could the geographic finding be related to water supply or proximity to an airborne caricnogen?

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Osaka University to pioneer world-first clinical trial for refractory prostate cancer with alpha-ray therapy