Optimal strategy to manage hypertension and preeclampsia at end of pregnancy

In 2009, the Hypertension and Preeclampsia Intervention Trial At near Term-I (HYPITAT- I) trial showed that inducing labor in women with gestational hypertension or preeclampsia at the end of pregnancy reduces the number of high risk situations for the mother, without compromising the health of newborns. An analysis published in Ultrasound in Obstetrics & Gynecology evaluated the impact of the HYPITAT-I findings on timing of labor and subsequent outcomes for mother and child in the Netherlands.

The analysis corroborated the results of the HYPITAT-I trial, concluding that inducing labor is the optimal management strategy. It showed that in the period after the HYPITAT-I trial, the rate of induction of labor at the end of pregnancy was increased in women with hypertensive disease in the Netherlands. This might have contributed to benefits for both women and their newborns.

With our impact analysis, we were able to evaluate whether expected results based on a randomized controlled trial were or could be reflected in daily care. Also, this is the only way to reveal unintended effects resulting from widespread adoption of interventions and therefore provides important information."

Lead author Catherine de Sonnaville, OLVG, Netherlands

Journal reference:

de Sonnaville, C. M. W. et al. (2019) Impact of Hypertension and Preeclampsia Intervention Trial At Near Term‐I (HYPITAT‐I) on obstetric management and outcome in The Netherlands. Ultrasound in Obstetrics & Gynecology. doi.org/10.1002/uog.20417.


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