Drug-sparing HIV regimens have become new standards of care, says GlobalData

Reductions in pill burden and dosing, improvements in safety and tolerability, and increased barriers to resistance have changed HIV management. As a result, therapies such as once-daily integrase inhibitor-based Gilead’s Biktarvy and Viiv’s Triumeq have become the new standards of care, says GlobalData, a leading data and analytics company.

Michael Breen, PhD, Associate Director of Infectious Diseases at GlobalData, comments:

With safe and efficacious treatments available such as Gilead’s Biktarvy and Viiv’s Triumeq, it could be reasoned that antiretroviral treatment (ART) mediated suppression of HIV is a minor unmet need, and that future efforts should focus on prevention or curing of this life-long infection."

Close examination of safety and efficacy data supports diverting attention away from ARTs, with Key Opinion Leaders (KOLs) interviewed by GlobalData reporting that room for improvement in these clinical parameters is marginal at best. However, this way of thinking eschews several factors that should weigh heavily in considering the long-term management of HIV.

As HIV integrates into the host’s genome, suppression of viral replication is required for the remainder of the patient’s lifespan. Accordingly, life-long treatment implies life-long exposure to at least three drugs - depending on the treatment plan. Minimization of drug exposure should be considered in all chronic disease management, including HIV, as long-term exposure increases the risk of side effects and complications.

Breen continues:

Drug developers are exploring how best to implement a drug-sparing strategy utilizing existing agents. While it is unclear what role these agents will play in the long-term HIV management, early data portending a role for this strategy in HIV management is encouraging. Efforts are also focusing on pill burden associated with long-term treatment, as moving from daily to monthly regimens could improve compliance and overall outcomes."

Viiv previously presented data showing that once-monthly injections of combination cabotegravir and Johnson & Johnson’s rilpivirine are as efficacious in control of viral loads as the highly impressive Triumeq.

In August 2019, ViiV presented Phase III data showing that this combination administered via injection once every two months is as efficacious as once-monthly injections. While this has the potential to reduce pill and treatment burden, insight on willingness to switch to or start on these injections rather than rely on oral therapies remains elusive. However, these injections could be of particularly high utility in patients where compliance issues have been noted. This is a particular concern in HIV, as irregular compliance is associated with increased drug resistance.

Viiv’s Juluca and Dovato received US Food and Drug Administration (FDA) approvals in 2017 and 2019, respectively, for treatment of HIV. However, Juluca’s use is limited to patients who are already on treatment and have undetectable viral loads, while Dovato is indicated for both treatment-experienced and treatment-naïve patients. These approvals mark the first steps in reducing drug exposure in HIV patients, however, uptake has been relatively modest. Juluca recorded only $189m in H1 2019. Viiv’s own Tivicay and Triumeq combined for $2.5bn over the same period, while Gilead’s Biktarvy saw sales of $1.7bn, indicating that three-drug regimens continue to dominate this space.

Breen concludes:

Drug-sparing HIV regimens will see an expanded role in HIV management, especially as physicians become more comfortable with using fewer ARTs. Importantly, this will also depend highly on patient receptivity to use of long-acting injectables and dynamics in usage of pre-exposure prophylaxis (PrEP). KOLs interviewed by GlobalData suggest this will see continued uptake, while noting that PrEP usage continues to lag behind what experts would hope to see, especially given PrEP’s efficacy in HIV prevention."



The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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