Scientists discover anti-cancer compound in the humble willow

More than a century after giving the world aspirin, another potential drug has been found in the stem and leaves of willows – this time with anti-cancer properties.

Scientists led from Rothamsted Research, working with cancer biologists at the University of Kent have discovered the chemical, miyabeacin, which has been found to kill various cancer cells, including those resistant to other drugs.

Of particular excitement is its activity against neuroblastoma, a hard to treat and common childhood cancer where the overall survival rate is below 50%.

In laboratory tests, miyabeacin was also found to be effective against several breast, throat and ovarian cancer cell lines.

Rothamsted’s Prof Mike Beale, a co-leader of the study said whilst the pharmaceutical activity of salicin, the active ingredient in aspirin, is well known, the pharmacological properties of miyabeacin are potentially even greater.

With resistance to treatment being a significant issue in cancers such as neuroblastoma, new drugs with novel modes of action are required and miyabeacin perhaps offers a new opportunity in this respect. Structurally, it contains two salicin groups that give it a potential ‘double dose’ of anti-inflammatory and anti-blood clotting ability that we associate with aspirin. However, our results reporting the activity of miyabeacin against a number of cancer cell lines, including cell lines with acquired drug resistance, adds further evidence for the multi-faceted pharmacology of willow.”

Professor Mike Beale, Co-leader of the study

After brain cancers, neuroblastoma is the most frequent solid tumor seen in the under-fives.

The team tested miyabeacin against a range of cancer cell lines. Initial cell viability assays were carried out on a neuroblastoma cell line established from a stage 4 neuroblastoma patient, and a drug resistant sub-line.

Professor Beale says the next steps are to scale up production of miyabeacin from farmed willow and provide more material for further medical testing.

The use of willow bark in medicine was recorded by ancient Greek, Assyrian and Egyptian civilizations, but the first scientifically reported investigation of willow as a remedy for fever was in 1763.

In 1897 the Bayer Company produced the synthetic analogue, aspirin (acetylsalicylate), one of the earliest and most successful nature-inspired drugs.

Rothamsted Research is home to the UK’s National Willow Collection, and in conjunction with the Institute’s established expertise in analytical chemistry, Dr Jane Ward, a co-leader of the study, puts the cancer breakthrough down to having 1500 willow species and hybrids available to screen with state of the art techniques.

Possibly because of the success of aspirin, medicinal assessment of other salicinoids in willow has been mostly neglected by modern science, and the National Willow Collection has proven to be a gold-mine of exciting new chemistry, that perhaps underlies its position in ancient therapies."

Dr Jane Ward, Co-leader of the study

Source:
Journal reference:

Ward, J.L., et al. (2020) Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy. Scientific Reports. doi.org/10.1038/s41598-020-63349-1.

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