Two studies demonstrate different ways to improve wearable bioelectronic devices

For years, automotive companies have developed intelligent sensors to provide real-time monitoring of a vehicle's health, including engine oil pressure, tire pressure and air-fuel mixture. Together, these sensors can provide an early warning system for a driver to identify a potential problem before it may need to be repaired.

Now, in a similar vein biologically, Zheng Yan, an assistant professor in the MU College of Engineering at the University of Missouri, has recently published two studies demonstrating different ways to improve wearable bioelectronic devices and materials to provide better real-time monitoring of a person's health, including vital signs.

Developing a 'smart' face mask

The onset of the COVID-19 pandemic has brought the idea of mask-wearing to the forefront of many people's minds. In response, one focus of Yan's lab has been to develop breathable soft bioelectronics. He said it was natural for him and his team to come up with the idea for integrating bioelectronics in a breathable face mask, which can monitor someone's physiological status based on the nature of the person's cough. Their findings were recently published in ACS Nano, a journal of the American Chemical Society.

Different respiratory problems lead to different cough frequencies and degrees. Taking chronic obstructive pulmonary disease (COPD) as an example, the frequency of cough in the early morning is higher than that in the daytime and night. Our smart face mask can effectively monitor cough frequencies, which may assist physicians with knowing disease development and providing timely, customized interventions."

Zheng Yan, Assistant Professor, MU College of Engineering, University of Missouri

In addition to monitoring someone's physiological status, the mask can also help identify proper mask wearing in public places using a bioelectronic sensor, Yan said. At this time, the mask does not have the capability to provide automatic reminders, but they would like to develop that function in the future.

Laser-assisted fabrication of wearable electronics

For a decade, scientists have been utilizing a laser-assisted fabrication approach, but Yan said one area that could still benefit from this approach is in building wearable bioelectronics.

"Laser-assisted fabrication is simple, scalable, cost-effective and easily customizable," Yan said. "This can lower the cost of wearable electronics and benefit both their practical, one-time use and personalization by providing customized devices for health care applications."

In a recent study published in Science Advances, a journal of the American Association for the Advancement of Science (AAAS), Yan and his team studied the potential of using a metallic conductor called MoO2.

"It exhibits high electrical conductivity, chemical stability, MRI-compatibility and biocompatibility, which is well suitable for construction of various bioelectronic sensors and stimulators," Yan said.

Yan said one potential application of this approach could be to help monitor a person's breathing.

"Monitoring a person's breathing rhythm will be useful for diagnosis of some diseases, such as sleep apnea," Yan said. "Also, we could concurrently monitor the heart rate, heart rate variation and electroencephalograms to provide more comprehensive information for the study of sleep apnea."