Deep learning for early osteoporosis risk prediction

Osteoporosis is so difficult to detect in early stage it's called the "silent disease." What if artificial intelligence could help predict a patient's chances of having the bone-loss disease before ever stepping into a doctor's office?

Tulane University researchers made progress toward that vision by developing a new deep learning algorithm that outperformed existing computer-based osteoporosis risk prediction methods, potentially leading to earlier diagnoses and better outcomes for patients with osteoporosis risk.

Their results were recently published in Frontiers in Artificial Intelligence.

Deep learning models have gained notice for their ability to mimic human neural networks and find trends within large datasets without being specifically programmed to do so. Researchers tested the deep neural network (DNN) model against four conventional machine learning algorithms and a traditional regression model, using data from over 8,000 participants aged 40 and older in the Louisiana Osteoporosis Study. The DNN achieved the best overall predictive performance, measured by scoring each model's ability to identify true positives and avoid mistakes.

The earlier osteoporosis risk is detected, the more time a patient has for preventative measures. We were pleased to see our DNN model outperform other models in accurately predicting the risk of osteoporosis in an aging population."

Chuan Qiu, lead author, research assistant professor at the Tulane School of Medicine Center for Biomedical Informatics and Genomics

In testing the algorithms using a large sample size of real-world health data, the researchers were also able to identify the 10 most important factors for predicting osteoporosis risk: weight, age, gender, grip strength, height, beer drinking, diastolic pressure, alcohol drinking, years of smoking, and income level.

Notably, the simplified DNN model using these top 10 risk factors performed nearly as well as the full model which included all risk factors.

While Qiu admitted that there is much more work to be done before an AI platform can be used by the public to predict an individual's risk of osteoporosis, he said identifying the benefits of the deep learning model was a step in that direction.

"Our final aim is to allow people to enter their information and receive highly accurate osteoporosis risk scores to empower them to seek treatment to strengthen their bones and reduce any further damage," Qiu said.

Journal reference:

Qiu, C., et al. (2024). Developing and comparing deep learning and machine learning algorithms for osteoporosis risk prediction. Frontiers in Artificial Intelligence.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Deep learning-based model development to predict critical pediatric events in general wards